The Inhibitory Effect of Deoxyadenosine and Deoxyguanosine on in Vitro Lymphocyte Function are Expressed at Different Stages of Lymphocyte Activation

Jg, Scharenberg; Rijkers, G.T.; Toebes, Elly A.H.; Lj, Spaapen; Ge, Staal; Bj, Zegers

doi:10.1007/978-1-4684-5104-7_91

Cited by 2 publications

(4 citation statements)

References 8 publications

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“…A KMT2D mutation was identified in only one sample but has similar epigenetic properties to KAT2B ( 49 ). Studies using The Cancer Genome Atlas database (TCGA) have associated mutations occurring in KMT2D , to the open chromatin state, thereby promoting gene expression ( 50 , 51 ). Mutations in KAT2B and KMT2D may induce epigenetic changes in both HNSCC and FOSCC that could advocate for the treatment with epigenetic drug control of both ( 47 , 51 ).…”

Section: Discussionmentioning

confidence: 99%

“…Studies using The Cancer Genome Atlas database (TCGA) have associated mutations occurring in KMT2D , to the open chromatin state, thereby promoting gene expression ( 50 , 51 ). Mutations in KAT2B and KMT2D may induce epigenetic changes in both HNSCC and FOSCC that could advocate for the treatment with epigenetic drug control of both ( 47 , 51 ). A missense mutation in ARID1A was found in one sample ( Supplementary Table S4 ), however, this gene did not show altered expression in FOSCC.…”

Section: Discussionmentioning

confidence: 99%

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Genomic landscape and gene expression profiles of feline oral squamous cell carcinoma

et al. 2023

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Feline oral squamous cell carcinoma (FOSCC) is a cancer of the squamous cell lining in the oral cavity and represents up to 80% of all oral cancers in cats, with a poor prognosis. We have used whole exome sequencing (WES) and RNA sequencing of the tumor to discover somatic mutations and gene expression changes that may be associated with FOSCC occurrence. FOSCC offers a potential comparative model to study human head and neck squamous cell carcinoma (HNSCC) due to its similar spontaneous formation, and morphological and histological features. In this first study using WES to identify somatic mutations in feline cancer, we have identified tumor-associated gene mutations in six cats with FOSCC and found some overlap with identified recurrently mutated genes observed in HNSCC. Four samples each had mutations in TP53, a common mutation in all cancers, but each was unique. Mutations in other cellular growth control genes were also found such as KAT2B and ARID1A. Enrichment analysis of FOSCC gene expression profiles suggests a molecular similarity to human OSCC as well, including alterations in epithelial to mesenchymal transition and IL6/JAK/STAT pathways. In this preliminary study, we present exome and transcriptome results that further our understanding of FOSCC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Genomic landscape and gene expression profiles of feline oral squamous cell carcinoma

et al. 2023

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“…KMT2D was identified in only one sample but has similar epigenetic properties to KAT2B. Studies completed by The Cancer Genome Atlas have shown mutations often occurring in KMT2D, keeping chromatin in an open state, thereby promoting gene expression 202,203 .…”

Section: Discussionmentioning

confidence: 99%

“…Mutations in both KAT2B and KMT2D possibly induce epigenetic changes in HHNSCC and FOSCC which alternative to immunotherapy could and may open an avenue to study epigenetic drug control of both human and feline oral squamous cell carcinoma 200,203 .…”

Section: Discussionmentioning

confidence: 99%

Characterization of the genetic landscape of feline oral squamous cell carcinoma

Rodney¹

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Over 94 million domestic cats are susceptible to cancers and other common and rare diseases. While cancer treatment in cats increasingly mirrors that available in humans, treatment failures are more frequent. There are no FDA or USDA approved cancer drugs for cats and a paucity of cancer treatments beyond surgery, radiotherapy, and cytotoxic chemotherapy indicate an urgent need to define the molecular properties of aggressive feline cancers including common cancers such as soft tissue sarcoma, mammary carcinoma, lymphoma, and feline oral squamous cell carcinoma. Whole exome sequencing (WES) is a proven strategy to study these disease-causing variants in humans and other organisms. To examine the effectiveness of WES in the study of feline cancer and Mendelian diseases, whole exome sequencing was conducted on 41 cats with known and unknown genetic diseases and traits, of which ten cats had matching whole genome sequence (WGS) data available, used to validate WES performance. Within the 41 cats, we identified 31 previously known causal variants and discovered new gene candidate variants, including novel missense variance for polycystic kidney disease and atrichia in the Peterbald cat. The WES data was sufficient to identify novel gene candidate alleles for diseases and traits in a feline model. Feline oral squamous cell carcinoma (FOSCC) is a cancer of the squamous cell lining in the oral cavity and represents up to 80 percent of all oral cancers in cats, with a low one-year survival rate of <10 percent. The cancer pathology associated with feline oral squamous cell carcinoma is similar to human head and neck squamous cell carcinoma (HNSCC), which accounts for 90 percent of oral cancers in humans. FOSCC may present as a potential model to study HNSCC due to spontaneous formation, similar genetic landscape, pathology, and survival rates. We have generated single nucleotide variant calls using GATK-Mutect2 on six cats with FOSCC and have fully annotated and identified driver genes in common with HNSCC. Due to low sample size, a larger cohort is needed to draw stronger association of disease-causing traits. Our results show some overlap in the genetic landscape of both cancers, with five samples have mutations in p53, a common mutation in HNSCC, and two samples having four genes in common with HNSCC each. Several samples with mutations in p53 and mutations in genes implicated in HNSCC suggests that the domestic cat could be a viable model for HNSCC.

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The Inhibitory Effect of Deoxyadenosine and Deoxyguanosine on in Vitro Lymphocyte Function are Expressed at Different Stages of Lymphocyte Activation

Cited by 2 publications

References 8 publications

Genomic landscape and gene expression profiles of feline oral squamous cell carcinoma

Genomic landscape and gene expression profiles of feline oral squamous cell carcinoma

Characterization of the genetic landscape of feline oral squamous cell carcinoma

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