The inhibitory effect of neurotensin on synaptosomal membrane Na+, K+-ATPase is altered by antipsychotic administration

Ordieres, Marı́a Graciela López; Arnaiz, Georgina Rodrı́guez de Lores

doi:10.1016/j.regpep.2005.02.004

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…, K ? -ATPase activity [19]. Such enhancement tended to diminish with 17.8 and 30.0 mg/kg clozapine doses (present results).…”

Section: Discussionsupporting

confidence: 70%

“…, K ? -ATPase activity in purified synaptosomal membranes fails to alter the enzyme [19]. As far as we know, there are not reports in the literature showing Na ?…”

Section: Discussionmentioning

confidence: 84%

“…, K ? -ATPase activity in membranes prepared after a dose of 10 mg/kg clozapine (i.p., 18 h) [19]. Mg 2?…”

Section: Resultsmentioning

confidence: 99%

“…-ATPase in membranes isolated from rat cerebral cortex turns to a stimulatory action if antipsychotic clozapine is previously administered i.p. to the rats (18 h, 10 mg/kg) [19].…”

Section: Introductionmentioning

confidence: 99%

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Clozapine Administration Modifies Neurotensin Effect on Synaptosomal Membrane Na+, K+ -ATPase Activity

Ordieres

Arnaiz

2009

Neurochem Res

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Na+, K+-ATPase is inhibited by neurotensin, an effect which involves the peptide high affinity receptor (NTS1). Neurotensin effect on cerebral cortex synaptosomal membrane Na+, K+-ATPase activity of rats injected i.p. with antipsychotic clozapine was studied. Whereas 3.5 x 10(-6) M neurotensin decreased 44% Na+, K+-ATPase activity in the controls, the peptide failed to modify enzyme activity 30 min after a single 3.0, 10.0 and 30.0 mg/kg clozapine dose. Neurotensin decreased Na+, K+-ATPase activity 40 or 20% 18 h after 3.0 or 5.6 mg/kg clozapine administration, respectively, and lacked inhibitory effect 18 h after 17.8 and 30.0 mg/kg clozapine doses. Results indicated that the clozapine treatment differentially modifies the further effect of neurotensin on synaptosomal membrane Na+, K+-ATPase activity according to time and dose conditions employed. Taken into account that clozapine blocks the dopaminergic D2 receptor, findings obtained favor the view of an interplay among neurotensinergic receptor, dopaminergic D2 receptor and Na+, K+-ATPase at synaptic membranes.

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“…, K ? -ATPase activity [19]. Such enhancement tended to diminish with 17.8 and 30.0 mg/kg clozapine doses (present results).…”

Section: Discussionsupporting

confidence: 70%

“…, K ? -ATPase activity in purified synaptosomal membranes fails to alter the enzyme [19]. As far as we know, there are not reports in the literature showing Na ?…”

Section: Discussionmentioning

confidence: 84%

See 2 more Smart Citations

Clozapine Administration Modifies Neurotensin Effect on Synaptosomal Membrane Na+, K+ -ATPase Activity

Ordieres

Arnaiz

2009

Neurochem Res

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“…-ATPase activity, to observe that the peptide inhibits the enzyme present in cortical synaptosomal membranes. This effect is entirely prevented by the presence of NTS1 receptor antagonist SR 48692 or pretreatment with dopaminergic D2 antagonist haloperidol [15,16].…”

Section: Introductionmentioning

confidence: 97%

Postnatal Nitric Oxide Inhibition Modifies Neurotensin Effect on ATPase Activity

et al. 2011

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We have previously showed that peptide neurotensin inhibits neuronal Na(+), K(+)-ATPase activity, an effect which involves high affinity neurotensin receptor. Nitric oxide (NO) acts as a neurotransmitter or as a neuromodulator when it is synthesized by neuronal nitric oxide synthase. Neurotensin effect on Na(+), K(+)-ATPase activity was evaluated in cortical synaptosomal membranes isolated from rats injected at 3, 4 and 5 postnatal days with saline (control) or N (ω)-nitro-L-arginine methyl esther (L-NAME), a nitric oxide synthase inhibitor. Assays were carried out at two stages: juvenile (35 days) and adult (56 days) ages. In an open field task, results recorded in juvenile rats markedly differed from those obtained in adult rats. The presence of neurotensin at 3.5 × 10(-8)-3.5 × 10(-6 )M concentration decreased 16-34% Na(+), K(+)-ATPase activity in membranes purified from control animals. At variance, the peptide failed to alter this enzyme activity in membranes obtained after L-NAME treatment. After administration of L-NAME, [(3)H]-ouabain binding to membranes isolated from adult male rats decreased 64% in the presence of 1.0 × 10(-6 )M neurotensin, a peptide concentration which only slightly decreased binding to membranes isolated from juvenile rats. It is postulated that early postnatal NO dysfunction may exert a permanent change in neurotensin system that influence later Na(+), K(+)-ATPase response to neurotensin.

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Neural Cell Behavior and Fuzzy Logic

Sandler¹,

Tsitolovsky²

2009

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The inhibitory effect of neurotensin on synaptosomal membrane Na+, K+-ATPase is altered by antipsychotic administration

Cited by 8 publications

References 20 publications

Clozapine Administration Modifies Neurotensin Effect on Synaptosomal Membrane Na+, K+ -ATPase Activity

Clozapine Administration Modifies Neurotensin Effect on Synaptosomal Membrane Na+, K+ -ATPase Activity

Postnatal Nitric Oxide Inhibition Modifies Neurotensin Effect on ATPase Activity

Neural Cell Behavior and Fuzzy Logic

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