The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

Figueiredo, Neusa; Aguiar, Sara R. M. M. de; Falé, Pedro L.; Ascensão, Lia; Serralheiro, Maria Luísa; Lino, A.R.

doi:10.1016/j.foodchem.2009.07.008

Cited by 28 publications

(16 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other concentrations tested; 50.4 (iv) and 25 µg/ml (v) were not toxic towards TZM-bl cells. P. barbatus has been reported to generally have low toxicity (Figueiredo et al, 2010) and the data obtained in the current study suggests that P. barbatus extract concentrations ≥100 µg/ml may result in high toxicity. The CC 50 for Auranofin, positive control for toxicity, was <10 µM in TZM-bl and PBMCs.…”

Section: Effect Of P Barbatus Extract On the Viability Of Tzm-bl Andsupporting

confidence: 53%

Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

Kapewangolo

Hussein

Meyer

2013

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Ethnopharmacological relevancePlectranthus barbatus is widely used in African countries as an herbal remedy to manage HIV/AIDS and related conditions. Aim of the studyTo investigate the HIV-1 inhibitory, anti-inflammatory and antioxidant properties of P. barbatus and thereby provide empirical evidence for the apparent anecdotal success of the extracts. Materials and methodsEthanolic extract of P. barbatus's leaves was screened against two HIV-1 enzymes; protease (PR) and reverse transcriptase (RT). Cytotoxicity of the extract was determined through measuring tetrazolium dye uptake of peripheral blood mononuclear cells (PBMCs) and the TZM-bl cell line. Confirmatory assays for cytotoxicity were performed using flow cytometry and real-time cell electronic sensing (RT-CES). The free radical scavenging activity of the extract was investigated with 2,2-diphenyl-1-picrylhydrazyl while the anti-inflammatory properties of the plant extract were investigated using a Th1/Th2/Th17 cytometric bead array technique. The extract exhibited strong antioxidant activity with an IC 50 of 16 µg/ml and reduced the production of pro-inflammatory cytokines indicating anti-inflammatory potential. ConclusionThis is the first demonstration of the in vitro anti HIV-1 potential of P. barbatus including direct activity as well as through the stimulation of protective immune and inflammation responses. The low cytotoxicity of the extract is also in agreement with the vast anecdotal use of this plant in treating various ailments with no reported side-effects.

show abstract

Section: Effect Of P Barbatus Extract On the Viability Of Tzm-bl Andsupporting

confidence: 53%

Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

Kapewangolo

Hussein

Meyer

2013

Journal of Ethnopharmacology

View full text Add to dashboard Cite

show abstract

“…Many researchers have been interested in preventing dental biofilm formation because bacterial adherence to tooth surfaces is a prerequisite to its formation and subsequent dental caries (Daglia et al, 2010;Figueiredo et al, 2010). Fig.…”

Section: Effects Of Selected Fraction and Curcuminoids On S Mutans Bmentioning

confidence: 99%

Separation of an effective fraction from turmeric against Streptococcus mutans biofilms by the comparison of curcuminoid content and anti-acidogenic activity

Pandit

Kim

et al. 2011

Food Chemistry

View full text Add to dashboard Cite

“…Plectranthus is a valuable source of secondary metabolites with proven cytotoxic, antiproliferative, anti-bacterial, anti-fungal, anti-plasmatic, or anti-cancer effects [6,7]. Numerous studies attribute these biological properties to the diterpenes expressed by this genus [8][9][10]. Our previous studies have demonstrated that the diterpenes isolated from Plectranthus genus induce apoptosis in various cancer cell lines, including human myeloid leukaemia, and pancreatic, lung, melanoma, prostate, and breast cancer [11][12][13][14][15][16][17].…”

mentioning

confidence: 99%

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

et al. 2020

View full text Add to dashboard Cite

Natural compounds isolated from plants are excellent starting points in drug design and have been widely studied as anticancer agents; they hence find use in a considerable proportion of anticancer drugs. The genus Plectranthus (Lamiaceae) comprises a large and widespread group of species with various applications in traditional medicine. Therefore, the aim of the present study was to determine the effectiveness of treatment with four abietane diterpenoids isolated from P. madagascariensis and P. ecklonii, 6,7-dehydroroyleanone, 7β,6β-dihydroxyroyleanone, 7α-acetoxy-6β-hydroxyroyleanone and parvifloron D, in initiating apoptosis in a glioma cell line. The pure compounds were found to exhibit anticancer effects in primary H7PX glioma cells line by inducing apoptosis G2/M cell cycle arrest and double-strand breaks, indicated by increased levels of phosphorylated H2A.X and decreasing mitochondrial membrane potential; they also influenced the expression of pro- and anti-apoptotic genes (Bax, Bcl-2, TP53, or Cas-3). Our findings indicate that these compounds may offer potential as beneficial antitumor drugs but further in vivo studies are needed.

show abstract

The inhibitory effect of Plectranthus barbatus and Plectranthus ecklonii leaves on the viability, glucosyltransferase activity and biofilm formation of Streptococcus sobrinus and Streptococcus mutans

Cited by 28 publications

References 23 publications

Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

Inhibition of HIV-1 enzymes, antioxidant and anti-inflammatory activities of Plectranthus barbatus

Separation of an effective fraction from turmeric against Streptococcus mutans biofilms by the comparison of curcuminoid content and anti-acidogenic activity

Insight the Biological Activities of Selected Abietane Diterpenes Isolated from Plectranthus spp.

Contact Info

Product

Resources

About