The Inhibitory Effect of Some Algerian Plants Phenolics Extracts on the &amp;#945; - glucosidase and &amp;#945; - amylase Activities and their Antioxidant Activities

Khacheba, Ihcen; Djeridane, Amar; Kameli, Abdelkrim; Yousfi, Mohamed

doi:10.2174/15734080113099990001

Cited by 11 publications

(8 citation statements)

References 19 publications

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“…[17] The IC 50 values for DPPH assay obtained from the fruit, leaf, and stem extracts of H. lippii were 0.25, 0.47, and 0.35 mg/ml, respectively. [19] Consistent with the previous findings, our results showed antioxidant activities (Figs. The authors concluded that the scavenging effect of the dichloromethane extract was five times stronger, whereas the effect of ethyl acetate extract was ten times stronger than the references used.…”

Section: Antioxidant Activitysupporting

confidence: 93%

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Phytochemical Profile and Biological Activities of Helianthemum canum l. baumg. from Turkey

Baldemir

Gökşen

Ildız

et al. 2017

Chemistry & Biodiversity

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In the current study, antioxidant, antibacterial activities, and the phenolic compositions of extracts from Helianthemum canum L. Baumg. (Apiaceae) aerial parts were investigated for the first time. The H. canum was extracted with 70% methanol (HCMeOH) and water (HCW). Both extracts were determined by total phenolic contents (3 mg/ml), flavonoids (1.5 mg/ml), flavonols (1.5 mg/ml), qualitative-quantitative compositions, iron (II) chelation activities (0.1 - 5 mg/ml), free radical scavenging activities (DPPH : 0.01 - 0.6 mg/ml and ABTS : 0.125 - 0.5 mg/ml) and the effect upon inhibition of β-carotene/linoleic acid co-oxidation (1 mg/ml). The peroxidation level was also determined using the thiobarbituric acid method (0.01 - 1.5 mg/ml). The results of the activity tests given as IC values were estimated from non-linear algorithm and compared with standards. Antibacterial activities of extracts and standards were evaluated against Gram-negative and -positive ten standard strains using disc diffusion and broth microdilution methods. The MIC results (312.5 - 2500 μg/ml) against tested microorganisms varied from 625 to 2500 μg/ml. In HPLC analysis, 3,5-dihydroxybenzoic acid was found as the main substance in both extracts. These results showed that HCMeOH was richer in phenolic compounds (284.13 ± 0.30 mg GAE/g extract) from HCW (244.55 ± 0.35 mg GAE/g extract) In conclusion, H. canum extracts showed in vitro antibacterial and antioxidant activities.

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Section: Antioxidant Activitysupporting

confidence: 93%

“…The authors concluded that the scavenging effect of the dichloromethane extract was five times stronger, whereas the effect of ethyl acetate extract was ten times stronger than the references used. [19] Consistent with the previous findings, our results showed antioxidant activities ( Figs. 2 and 3).…”

Section: Antioxidant Activitysupporting

confidence: 93%

Phytochemical Profile and Biological Activities of Helianthemum canum l. baumg. from Turkey

Baldemir

Gökşen

Ildız

et al. 2017

Chemistry & Biodiversity

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“…If we compare the values of in this work with those of the study of Khacheba et al [33], we found that our values are higher. This made can conclude that our samples are low inhibteur which is the result of the type of extraction; our extracts are too polar and have extracte all polar compounds may interfere with the mechanism of inhibition or by the fact that the plants studied by Khacheba and their collaborator present the exsitance of compounds with different structure gives them a largest inhibitory activity.…”

Section: Inhibition Of Fungal -Amylasesupporting

confidence: 56%

“…The inhibition rates in almost all of the tested plants are higher than that in other studies on other plant species in the region of Laghouat of the studies of khacheba et al [33]. This high among registered for our plants may be related to a type of extraction (infusion) and the highly polar nature of the solvent used which extracts a large number of inhibitory molecules which explains the use of these herbal plants by infusion in traditional medicine.…”

Section: Inhibition Of Fungal -Amylasecontrasting

confidence: 50%

Twenty Traditional Algerian Plants Used in Diabetes Therapy as Strong Inhibitors of α-Amylase Activity

Khacheba

Djeridane

Yousfi

2014

International Journal of Carbohydrate Chemistry

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In the present work, we have studied the inhibitory effects of aqueous and alcoholic extracts of six Algerian medicinal plants known by their therapeutic virtues against diabetes. The total phenolic compounds content, assayed using Folin-Ciocalteu's reagent, of the samples ranged from 0.183 mg/g to 43.088 mg/g and from 1.197 mg/g to 7.445 mg/g, expressed as gallic acid equivalent (GAE), for the, respectively, whereas the total flavonoids concentrations, detected using 2% of the aluminium chloride, ranged from 0.41 mg/g to 11.613 mg/g and from 0.0097 mg/g to 1.591 mg/g, expressed as rutin equivalents (RE), for the aqueous and methanolic extracts, respectively. The major plants were found to inhibit enzymatic activities of Aspergillus oryzae-amylase in a concentration dependent manner. The values of the inhibition constants ( ) have been determined according to the Dixon and Lineweaver-Burk methods. The results showed that the values were less than 55 ppm for the all extracts. A strong inhibition was found in the phenolic extract of Salvia officinalis with a of 8 ppm.

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“…[ 2 3 ] Traditionally, S. imbricata is used as a diuretic and anti-inflammatory agent. [ 4 ] It has also been reported to possess antioxidant[ 5 ] and antidiabetic activity;[ 6 ] in addition, it inhibits tyrosinase[ 7 8 ] and leads to central nervous system depression. [ 9 ] S. imbricata was reported to contain triterpene glycoside derivatives,[ 10 ] triterpenes,[ 5 ] isoflavonoids, flavonoids, coumarins,[ 8 11 ] alkaloidal phenolics,[ 7 12 ] and sterols.…”

Section: Introductionmentioning

confidence: 99%

New isorhamnetin derivatives from Salsola imbricata Forssk. leaves with distinct anti -inflammatory activity

El‐Kashak

Raey²

2016

Phcog Mag

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Background:Salsola imbricata Forssk. is a shrub widely growing in Egypt, used as a camel food, traditionally, used as anti-inflammatory agent. Literature survey showed no report about the anti-inflammatory activity of S. imbricata.Aim of the Study:This work was designed to study the phenolic constituents and to provide evidence for the traditional use of S. imbricata as an anti-inflammatory agent.Materials and Methods:The in vitro anti-inflammatory activity of the total aqueous methanol extract and some isolated compounds were investigated in RAW 264.7 macrophage cells using nitric oxide assay. All chemical structures were identified on the basis of electrospray ionization-mass spectrometry, one- and two-dimension nuclear magnetic resonance.Results:Nine phenolic compounds, among them two new natural products; isorhamnetin-3-O-β-D-glucuronyl (1’’’→4’’) glucuronide (1) and its dimethyl ester; isorhamnetin-3-O-β-D-di glucuronate dimethyl ester (2), two isorhamnetin glycosides: Isorhamnetin-3-O-β-D-galactopyranoside (3), isorhamnetin-3-O-β-D-glucopyranoside (4), and isorhamnetin (5). In addition, an alkaloidal phenolic; trans N-feruloyl tyramine (6), three phenolic acids: Isovanillic acid (7), ferulic acid (8), and p-hydroxy benzoic acid (9) were isolated from salsola imbricata leaves. All compounds were isolated and identified for the first time from this plant except compound (6). The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells.Conclusion:The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells.SUMMARY Investigation of the chemical constituents of the leaves of Salsola imbricata led to isolation of two new isorhamnetin derivatives: isorhamnetin.3-O-β-D.glucuronyl (1’“→”) glucuronide (1) and its dimethyl ester (2), together with seven known phenolic compounds. The extract and the tested compounds showed distintict anti-inflammatory activities with no toxicity on RAW 264.7 macrophage cells. Abbreviations used: PC: Paper chromatography, MPLC : Medium Pressure Liquid Chromatography, HMBC: Heteronuclear multiple bond correlation, HMQC: Heteronuclear single quantum correlation, NMR: Nuclear magnetic resonance

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The Inhibitory Effect of Some Algerian Plants Phenolics Extracts on the α - glucosidase and α - amylase Activities and their Antioxidant Activities

Cited by 11 publications

References 19 publications

Phytochemical Profile and Biological Activities of Helianthemum canum l. baumg. from Turkey

Phytochemical Profile and Biological Activities of Helianthemum canum l. baumg. from Turkey

Twenty Traditional Algerian Plants Used in Diabetes Therapy as Strong Inhibitors of α-Amylase Activity

New isorhamnetin derivatives from Salsola imbricata Forssk. leaves with distinct anti -inflammatory activity

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