The inhibitory effect of tachyplesin I on thrombosis and its mechanisms

Li, Huimin; Liu, Bin; Wu, Jun; Yu, Huajun; Huang, Hui; Chen, Xi; Chen, Baoan; Wu, Shang; Ma, Jingyao; Liu, Wen; Chen, Xiaoyi; Lan, Liubo; He, Zhan; Zhang, Haitao

doi:10.1111/cbdd.13570

Cited by 6 publications

(8 citation statements)

References 38 publications

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“…However, ST can inhibit the secretion of CA caused by acetylcholine stimulation of bovine adrenal medulla cells in a dose-dependent manner. The mechanism is mainly related to the nAChR pathway on the cell membrane and the voltagedependent sodium ion channel (Liu et al, 2010b), suggesting that ST can achieve the effect of "brain regulates the heart" by regulating the CNS in the treatment of cardiovascular diseases.…”

Section: Anti-myocardial Ischemiamentioning

confidence: 99%

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Yuan

et al. 2021

Front. Pharmacol.

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In recent years, the incidence and mortality of cardio-cerebrovascular diseases have been increasing year by year, which has become global burden and challenge. Based on the holistic thinking of “brain disease affects the heart” and “heart disease affects the brain,” as well as the characteristics of multi-target and multi-path effects of Chinese medicine, Chinese medicine is more advantageous in the treatment of cardio-cerebrovascular diseases. As a botanical medicine, storax is known for its resuscitation, filth avoidance and pain-relieving effects in the treatment of cardio-cerebrovascular diseases. By reviewing and collating the relevant domestic and international literature in the past 10 years, we have sorted out an overview of the medicinal parts, traditional uses and chemical composition of storax. For the first time, based on the idea of “cerebral and cardiac simultaneous treatment,” the pharmacological activities and mechanisms of heart and brain protection of storax for treating cardio-cerebrovascular diseases were summarized and analyzed, showing that storax has the pharmacological effects of anti-cerebral ischemia, regulation of blood-brain barrier, bidirectional regulation of the central nervous system, anti-myocardial ischemia, anti-arrhythmia, anti-thrombosis and anti-platelet aggregation. It mainly exerts its protective effects on the brain and heart through mechanisms such as inhibition of inflammatory immune factors, anti-oxidative stress, anti-apoptosis, pro-neovascularization and regulation of NO release. On the basis of the current findings and limitations, the future research strategies and perspectives of storax are proposed, with a view to providing a reference for further application and development of this medicine, as well as contributing new thoughts and visions for the clinical application of “treating brain-heart synchronously”.

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Section: Anti-myocardial Ischemiamentioning

confidence: 99%

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Yuan

et al. 2021

Front. Pharmacol.

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“…Tachyplesin I also exhibits high antithrombotic activity. It inhibits platelet aggregation and thrombosis by meddling with the PI3K/protein kinase B pathway …”

Section: Application and Potential Role Of Bioactive Proteins And Pep...mentioning

confidence: 99%

“…It inhibits platelet aggregation and thrombosis by meddling with the PI3K/ protein kinase B pathway. 24 Several global tests are available to evaluate the function of the coagulation system, including PT, aPTT, and TT (Figure 3B). Rajapakse et al discovered that certain proteins can form an inactive complex with FXIIa, thereby inhibiting its activity.…”

Section: Application and Potential Role Of Bioactive Proteins And Pep...mentioning

confidence: 99%

Nutrition and Cardiovascular Disease: The Potential Role of Marine Bioactive Proteins and Peptides in Thrombosis Prevention

Cheng,

Yuan,

Li-Gao

et al. 2024

J. Agric. Food Chem.

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Thrombus and cardiovascular diseases pose a significant health threat, and dietary interventions have shown promising potential in reducing the incidence of these diseases. Marine bioactive proteins and peptides have been extensively studied for their antithrombotic properties. They can inhibit platelet activation and aggregation by binding to key receptors on the platelet surface. Additionally, they can competitively anchor to critical enzyme sites, leading to the inhibition of coagulation factors. Marine microorganisms also offer alternative sources for the development of novel fibrinolytic proteins, which can help dissolve blood clots. The advancements in technologies, such as targeted hydrolysis, specific purification, and encapsulation, have provided a solid foundation for the industrialization of bioactive peptides. These techniques enable precise control over the production and delivery of bioactive peptides, enhancing their efficacy and safety. However, it is important to note that further research and clinical studies are needed to fully understand the mechanisms of action and therapeutic potential of marine bioactive proteins and peptides in mitigating thrombotic events. The challenges and future application perspectives of these bioactive peptides also need to be explored.

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“…It also inhibited platelet aggregation and thrombosis by interfering with the PI3K/protein kinase B (AKT) pathway. Due to its low toxicity and targeted action, it has potential to be developed as a novel antithrombotic drug [ 53 ].…”

Section: Marine Antithromboticsmentioning

confidence: 99%

Marine Antithrombotics

Dwivedi

Pomin

2020

Marine Drugs

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Thrombosis remains a prime reason of mortality worldwide. With the available antithrombotic drugs, bleeding remains the major downside of current treatments. This raises a clinical concern for all patients undergoing antithrombotic therapy. Novel antithrombotics from marine sources offer a promising therapeutic alternative to this pathology. However, for any potential new molecule to be introduced as a real alternative to existing drugs, the exhibition of comparable anticoagulant potential with minimal off-target effects must be achieved. The relevance of marine antithrombotics, particularly sulfated polysaccharides, is largely due to their unique mechanisms of action and lack of bleeding. There have been many investigations in the field and, in recent years, results have confirmed the role of potential marine molecules as alternative antithrombotics. Nonetheless, further clinical studies are required. This review covers the core of the data available so far regarding the science of marine molecules with potential medical applications to treat thrombosis. After a general discussion about the major biochemical steps involved in this pathology, we discuss the key structural and biomedical aspects of marine molecules of both low and high molecular weight endowed with antithrombotic/anticoagulant properties.

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The inhibitory effect of tachyplesin I on thrombosis and its mechanisms

Cited by 6 publications

References 38 publications

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Nutrition and Cardiovascular Disease: The Potential Role of Marine Bioactive Proteins and Peptides in Thrombosis Prevention

Marine Antithrombotics

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