The inhibitory effects and mechanisms of polymannuroguluronate sulfate against human papillomavirus infection in vitro and in vivo

Wang, Shixin; Lü, Zhe; Wang, Shuyao; Liu, Wei; Gao, Jiangming; Tian, Linan; Wang, Li; Zhang, Xiaoshuang; Zhao, Xia; Wang, Wei; Li, Chunxia

doi:10.1016/j.carbpol.2020.116365

Cited by 14 publications

(12 citation statements)

References 30 publications

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“…This interaction is virustatic, holding virions inert and preventing infection. A similar mechanism has been suggested across many other types of algae-derived polysaccharides, including xylomannan [ 97 ], p-KG03 [ 98 ], AEX [ 99 ], GFP [ 100 ], and PMG [ 64 ].…”

Section: Viral Pathogenesismentioning

confidence: 58%

“…PMG is a sulfated polysaccharide derived from seaweed in the class Phaeophyceae. Research performed by Wang et al found that an LMW (10 kDa) PMG had potent anti-HPV effects in vitro and in vivo using a murine skin-infection model [ 64 ] ( Table 2 ). In this study, mice were scarified using an abrasive hand tool and then inoculated with HPV in solution.…”

Section: Viral Pathogenesismentioning

confidence: 99%

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Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis

et al. 2021

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Viruses are abiotic obligate parasites utilizing complex mechanisms to hijack cellular machinery and reproduce, causing multiple harmful effects in the process. Viruses represent a growing global health concern; at the time of writing, COVID-19 has killed at least two million people around the world and devastated global economies. Lingering concern regarding the virus' prevalence yet hampers return to normalcy. While catastrophic in and of itself, COVID-19 further heralds in a new era of human-disease interaction characterized by the emergence of novel viruses from natural sources with heretofore unseen frequency. Due to deforestation, population growth, and climate change, we are encountering more viruses that can infect larger groups of people with greater ease and increasingly severe outcomes. The devastation of COVID-19 and forecasts of future human/disease interactions call for a creative reconsideration of global response to infectious disease. There is an urgent need for accessible, cost-effective antiviral (AV) drugs that can be mass-produced and widely distributed to large populations. Development of AV drugs should be informed by a thorough understanding of viral structure and function as well as human biology. To maximize efficacy, minimize cost, and reduce development of drug-resistance, these drugs would ideally operate through a varied set of mechanisms at multiple stages throughout the course of infection. Due to their abundance and diversity, natural compounds are ideal for such comprehensive therapeutic interventions. Promising sources of such drugs are found throughout nature; especially remarkable are the algae, a polyphyletic grouping of phototrophs that produce diverse bioactive compounds. While not much literature has been published on the subject, studies have shown that these compounds exert antiviral effects at different stages of viral pathogenesis. In this review, we follow the course of viral infection in the human body and evaluate the AV effects of algae-derived compounds at each stage. Specifically, we examine the AV activities of algae-derived compounds at the entry of viruses into the body, transport through the body via the lymph and blood, infection of target cells, and immune response. We discuss what is known about algae-derived compounds that may interfere with the infection pathways of SARS-CoV-2; and review which algae are promising sources for AV agents or AV precursors that, with further investigation, may yield life-saving drugs due to their diversity of mechanisms and exceptional pharmaceutical potential.

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Section: Viral Pathogenesismentioning

confidence: 58%

Section: Viral Pathogenesismentioning

confidence: 99%

Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis

et al. 2021

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“…Polymannuroguluronate (PMG) is a common low-molecular-weight alginate. Polymannuroguluronate sulfate (PMGS) is capable of inactivating HPV particles and of blocking virus capsid L1 protein binding, and downregulating the levels of the E6 and E7 viral oncogenic proteins [ 109 ]. In addition, sulfated polymannuronate (SPMG) inhibits the interaction between the HIV-1 gp120 protein and the CD4 + T lymphocyte receptor, thus preventing entry of the virus into the lymphocyte [ 110 ].…”

Section: Sulfated Polysaccharides From Different Seaweedsmentioning

confidence: 99%

Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds

Wei

Wang

et al. 2022

Pharmaceuticals

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In recent years, various viral diseases have suddenly erupted, resulting in widespread infection and death. A variety of biological activities from marine natural products have gradually attracted the attention of people. Seaweeds have a wide range of sources, huge output, and high economic benefits. This is very promising in the pharmaceutical industry. In particular, sulfated polysaccharides derived from seaweeds, considered a potential source of bioactive compounds for drug development, have shown antiviral activity against a broad spectrum of viruses, mainly including common DNA viruses and RNA viruses. In addition, sulfated polysaccharides can also improve the body’s immunity. This review focuses on recent advances in antiviral research on the sulfated polysaccharides from seaweeds, including carrageenan, galactan, fucoidan, alginate, ulvan, p-KG03, naviculan, and calcium spirulan. We hope that this review will provide new ideas for the development of COVID-19 therapeutics and vaccines.

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“…Alginate, a soluble acidic polysaccharide found in brown seaweeds, composed of a central backbone of poly-d-mannuronic acid (PM), poly-l-guluronic acid (PG), and alternate residues of d-mannuronic acid and l-guluronic acid (PMG), was shown to significantly inhibit HPV16-and HPV18-PsVs infection of HEK-293FT, HeLa and HaCaT cells, with IC 50 values ranging between 0.7 and 3.3 µg/mL [104]. Further studies with HPV45-PsVs indicated that PMGs may block the very early steps of the viral life cycle by directly associating with the L1 protein [104]. Using a murine skin infection model, the researchers showed a significant reduction in HPV45-PsVs infection when particles were pretreated with PMGs (10 mg) or when PMGs were administered during infection.…”

Section: Naturally Derived Sulfated Polysaccharidesmentioning

confidence: 99%

Advances in Targeting HPV Infection as Potential Alternative Prophylactic Means

Carse

Bergant

Schäfer

2021

IJMS

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Infection by oncogenic human papillomavirus (HPV) is the primary cause of cervical cancer and other anogenital cancers. The majority of cervical cancer cases occur in low- and middle- income countries (LMIC). Concurrent infection with Human Immunodeficiency Virus (HIV) further increases the risk of HPV infection and exacerbates disease onset and progression. Highly effective prophylactic vaccines do exist to combat HPV infection with the most common oncogenic types, but the accessibility to these in LMIC is severely limited due to cost, difficulties in accessing the target population, cultural issues, and maintenance of a cold chain. Alternative preventive measures against HPV infection that are more accessible and affordable are therefore also needed to control cervical cancer risk. There are several efforts in identifying such alternative prophylactics which target key molecules involved in early HPV infection events. This review summarizes the current knowledge of the initial steps in HPV infection, from host cell-surface engagement to cellular trafficking of the viral genome before arrival in the nucleus. The key molecules that can be potentially targeted are highlighted, and a discussion on their applicability as alternative preventive means against HPV infection, with a focus on LMIC, is presented.

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The inhibitory effects and mechanisms of polymannuroguluronate sulfate against human papillomavirus infection in vitro and in vivo

Cited by 14 publications

References 30 publications

Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis

Viral inhibitors derived from macroalgae, microalgae, and cyanobacteria: A review of antiviral potential throughout pathogenesis

Advances in Research on Antiviral Activities of Sulfated Polysaccharides from Seaweeds

Advances in Targeting HPV Infection as Potential Alternative Prophylactic Means

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