The Inhibitory Effects of Djulis (Chenopodium formosanum) and Its Bioactive Compounds on Adipogenesis in 3T3-L1 Adipocytes

Chyau, Charng-Cherng; Chu, Chin-Chen; Chen, Shih‐Ying; Duh, Pin-Der

doi:10.3390/molecules23071780

Cited by 46 publications

(53 citation statements)

References 35 publications

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“…Intriguingly, this metabolite was not mentioned in a recent comparative metabolomic study of these two Lycium fruits 3 . As rutin derivatives have antioxidant potential and show low cytotoxicity in human and animal cells, which makes them promising potential candidates for use as nutraceuticals 69 , and as there are indications that rutin may suppress lipid accumulation in humans 70 , high rutin content in LR berries may be interesting from the nutritional and pharmaceutical perspective.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening

Zhao

Yin

et al. 2020

Sci Rep

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Red wolfberry (or goji berry, Lycium barbarum; LB) is an important agricultural product with a high content of pharmacologically important secondary metabolites such as phenylpropanoids. A close relative, black wolfberry (L. ruthenicum; LR), endemic to the salinized deserts of northwestern china, is used only locally. The two fruits exhibit many morphological and phytochemical differences, but genetic mechanisms underlying them remain poorly explored. in order to identify the genes of interest for further studies, we studied transcriptomic (Illumina HiSeq) and metabolomic (LC-MS) profiles of the two fruits during five developmental stages (young to ripe). As expected, we identified much higher numbers of significantly differentially regulated genes (DEGs) than metabolites. The highest numbers were identified in pairwise comparisons including the first stage for both species, but total numbers were consistently somewhat lower for the LR. The number of differentially regulated metabolites in pairwise comparisons of developmental stages varied from 66 (stages 3 vs 4) to 133 (stages 2 vs 5) in both species. We identified a number of genes (e.g. AAT1, metE, pip) and metabolites (e.g. rutin, raffinose, galactinol, trehalose, citrulline and DL-arginine) that may be of interest to future functional studies of stress adaptation in plants. As LB is also highly suitable for combating soil desertification and alleviating soil salinity/alkalinity/pollution, its potential for human use may be much wider than its current, highly localized, relevance.Despite their close phylogenetic relationship, the fruits of these two species exhibit distinct phenotypic profiles of during all developmental stages, including their shape, size, colour, taste, nutritional value and pharmacological properties 3,4,11 . As opposed to the red and elongated mature red wolfberry, black wolfberry is dark-purple or black, round, and smaller. It is also known that metabolic phenotypes of these two fruits differ significantly, particularly in the content of fatty acids, phenols and antioxidant capacities, which are much higher in black wolfberry, while the content of carotenoids, sugars, amino acids and osmolytes is higher in the red wolfberry 3,4 .Fruit ripening is a complex developmental process, coordinated by a network of interacting genes and signalling pathways 12 , so genetic mechanisms underpinning these phenotypic differences remain only partially understood. The objective of this study was to contribute to our understanding of the complexity of ripening processes of these two fruits in different environments. To achieve this, we collected L. barbarum and L. ruthenicum fruits at five developmental stages, from young to ripe fruit, and sequenced their transcriptomes and metabolomes. These data shall help us better understand genetic underpinnings of both within-and between-species phenotypic differences that fruits of these two species exhibit during their respective ripening processes. Materials and methodsSample collection. Fruits were collected ...

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Section: Discussionmentioning

confidence: 99%

Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening

Zhao

Yin

et al. 2020

Sci Rep

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“…Betanin, in the range from 10-100 µM did not elicit any cytotoxicity effect on survival. However, betanin significantly inhibited adipocyte cell differentiation and lipid accumulation [76]. Since obesity increases cancer risk, one possible mechanism for betanins chemoprevention could be related to impeding this risk factor.…”

Section: Betanins Cytotoxicity Of Cultured Cellsmentioning

confidence: 97%

Red Beetroot and Betalains as Cancer Chemopreventative Agents

Lechner¹,

Stoner²

2019

Preprint

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Carcinogenesis is the process whereby a normal cell is transformed into a neoplastic cell.  This action involves several steps starting with initiation and followed by promotion and progression.  Driving these stages are oxidative stress and inflammation, which in turn encompasses a myriad of aberrant gene expressions, both within the transforming cell population and the cells within the surrounding lesion.  Chemoprevention of cancer with bioreactive foods or their extracted/purified components occurs via normalizing these inappropriate gene activities.  Various foods/agents have been shown to affect different gene expressions.  In this review we discuss whereby the chemoprevention activities of the red beetroot itself may disrupt carcinogenesis and the activities of the water soluble betalains extracted from the plant.

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“…Two studies have been performed to investigate whether betanin plays a role in adipogenesis or not [74,75]. Both studies have depicted that treatment of 3T3-L1 cells with either betanin [74] or the ethanolic extracts of Djulis [75], which contains eleven ingredients in addition to betanin have resulted in the formation of a fewer number of oil droplets indicating reduced lipid accumulation. These manifestations were dose dependent with betanin concentrations in the range of 10-50 µM.…”

Section: Betanin and Lipogenesismentioning

confidence: 99%

Betanin: a promising molecule for biomedical applications

2020

Biointerface Res Appl Chem

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Plants with medicinal properties possess beneficial influences on health and disease. Different plant parts and extracts carry valuable active ingredients with pharmacological properties that lead to developing new drugs. Terminalia bellirica is among those plants that have been formulated as pharmaceutical products. This is attributed to its biologically active phenolics and tannins exhibiting analgesic, anti-hypertensive, anti-microbial, anti-diabetic, anti-oxidant, as well as, other pharmacological properties. Beetroot has been shown to be rich in nitrates with a positive impact on the cardiovascular system. Beetroot contains a number of useful ingredients as the free-radical scavenger ascorbic acid, the anti-inflammatory flavonoids and the anti-oxidant carotenoids. Moreover, beetroot is rich in the natural colorant betalains that are further classified into betacyanins and betaxanthins. Betanin, is one of the major constituents of beetroots that have been postulated to possess significant beneficial therapeutic effects in a number of conditions and diseases. However, several studies have demonstrated the relatively poor bioavailability of betanin upon oral administration. In the current review we aim to highlight some of the latest researches dealing with the therapeutic properties of betanin in different disease conditions, the possible mechanistic pathways beyond such beneficial effects and plausible strategies capable of enhancing its stability and bioavailability.

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The Inhibitory Effects of Djulis (Chenopodium formosanum) and Its Bioactive Compounds on Adipogenesis in 3T3-L1 Adipocytes

Cited by 46 publications

References 35 publications

Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening

Transcriptomic and metabolomic analyses of Lycium ruthenicum and Lycium barbarum fruits during ripening

Red Beetroot and Betalains as Cancer Chemopreventative Agents

Betanin: a promising molecule for biomedical applications

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