The inhibitory influence of toluene on mare ovarian granulosa cells can be prevented by fennel

Tarko, Adam; Fabová, Zuzana; Kotwica, J.; Valocký, Igor; Alrezaki, Abdulkarem; Alwasel, Saleh; Harrath, Abdel Halim; Sirotkin, Alexander V.

doi:10.1016/j.ygcen.2020.113491

Cited by 12 publications

(21 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, studies reporting its effects on ovarian function are still limited. In our previous in vitro studies, we demonstrated that toluene inhibited ovarian cell viability, proliferation and estrogen release [ 38 , 44 ]. In this study, we investigated the in vivo effect of toluene using female Wistar rats.…”

Section: Discussionmentioning

confidence: 99%

“…However, in vivo evidence in support of the main mechanisms of the toluene effect on ovary function is still limited, particularly the induction of autophagic and apoptosis. In our recent in vitro studies, we demonstrated, using cultured healthy mare ovarian granulosa cells, that toluene inhibited viability, proliferation, apoptosis, progesterone, prostaglandin F and IGF-I release [ 38 , 39 , 40 ]. To advance our knowledge on the effect of toluene on female reproduction, an in vivo study using female Wistar rats is investigated.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Toluene Can Disrupt Rat Ovarian Follicullogenesis and Steroidogenesis and Induce Both Autophagy and Apoptosis

Alrezaki

Aldawood

Mansour

et al. 2021

Biology

View full text Add to dashboard Cite

Toluene has been shown to be highly toxic to humans and animals and can cause damage to various tissues. However, studies reporting its effects on ovarian function are still limited. In this study, we investigated the in vivo effect of toluene using female Wistar rats. We found that toluene exposure decreased ovarian weight and affected ovarian structure by increasing the number of abnormally growing follicles. Moreover, it significantly increased progesterone and testosterone levels. We also showed that toluene exposure decreased GDF-9 protein and its encoding gene. In addition, it inhibited the expression of most of the genes involved in granulosa cell proliferation and differentiation, such as Insl3, ccnd2 and actb. The TUNEL assay showed that apoptosis occurred at the middle and high doses only (4000 and 8000 ppm, respectively), whereas no effect was observed at the low dose (2000 ppm). Interestingly, we showed that toluene exposure induced autophagy as LC3 protein and its encoding gene significantly increased for all doses of treatment. These results may suggest that the activation of autophagy at a low dose of exposure was to protect ovarian cells against death by inhibiting apoptosis, whereas its activation at high doses of exposure triggered apoptosis leading to cell death.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Toluene Can Disrupt Rat Ovarian Follicullogenesis and Steroidogenesis and Induce Both Autophagy and Apoptosis

Alrezaki

Aldawood

Mansour

et al. 2021

Biology

View full text Add to dashboard Cite

show abstract

“…On the other hand, despite extensive study and public discussion of the adverse effects of environmental contaminants, there still no strong experimental evidence for it. This opinion is based mainly on the indirect indicesassociation between health disorders rate and occupational exposition of the limited number of people to environmental contaminants (Sirotkin and Harrath 2017;Tarko et al 2020;Tenailleau et al 2020) or presence of these contaminants in tissues (Bocato et al 2019). The available data concerning the association between exposure to contaminants and objective physiological parameters are few, contradictory and usually inconclusive (Louzen et al 2019).…”

Section: Mythic Interconnectionmentioning

confidence: 99%

“…Moreover, sometimes even this evidence is ambiguous. For example, there are indications, that benzene and xylene, which are commonly considered as a dangerous oilrelated environmental contaminant, cannot suppress, but promote ovarian cell functions (Tarko et al 2019;Sirotkin et al 2020).…”

Section: Mythic Interconnectionmentioning

confidence: 99%

“…The folk traditions, influence of eastern medicine, lack of satisfaction with synthetic pharmacological drugs and food producers are promoting the wide application of some plants containing phytoestrogens and antioxidants for improvement of not only metabolism but also of reproduction and fertility. The corresponding studies however demonstrated the ability of popular green tea (Baláži et al 2019), turmeric/curcumin (Kádasi et al 2017), rooibos, ginkgo (Štochmaľová et al 2018), fennel (Tarko et al 2020), flaxseed (Štochmaľová et al 2019), and their constituent phytoestrogen quercetin (Tarko et al 2018(Tarko et al , 2019Sirotkin et al 2019a,b) not improve, but directly suppress animal and human ovarian cell functions. These unexpected data should be taken into account by the consumption and overconsumption of these popular plants.…”

Section: Mythic Interconnectionmentioning

confidence: 99%

See 1 more Smart Citation

Untitled

2020

REJHSS

View full text Add to dashboard Cite

The cross-cutting theme of the 3/2 issue of Researcher is the problem of transformation of human nature in civilizational, historical, and cultural dimensions. The opening essay by Ilia Delio focuses on the current semantic context of this transformation and its cons equences, which change taken for granted values in daily life. The author announces the end of an era that affirms the value of an autonomous liberal subject, and connects the future with the beginning of the history of post-human being, a new type of personality integrated into the "maps of connections" (through socialism, pol itics, environment, economics, sexuality, etc.). Arkady Ursul develops the topic of information transformation, which shows that essence of globalization is the approval of the tr iad of universals: spatial distribution, integration and universality. Through the prism of these universals, the author considers cultu ral genesis and predicts the "global developmental algorithms" of man in the information world. Konstantin Kolin analyzes the main challenges of modern civil ization that should be overcome in the process of globalist discourse of civilizational transformation. The author includes the geopolit ical concept of "nuclear deterrence", the ideology of post-industrial society, the exhaustion of natural resources, and the development of artificial intelligence to these challenges. The answer to these challenges should be a new enlightenment in which the focus is on caring for the future of the planet, and on finding a balance in sol ving global problems. An essay by Italian researcher of Russian history, Ornella Calvarese, is dedicated to the wandering bards of ancient Russiakaliki. Turning to the study of a Russian Middle Ages phenomenon, the author draws a conclusion about the cultural role of spiritual nomadism, which has influenced and still continues to influence the Russian worldview. A deep historical perspective allows us to recreate the past, reveal hidden meanings, restore national identity against the background of spasmodic, often interrupted stages of transformation of Russian culture. We continue to publish Nadezhda Gonotskaya's research piece "Recipe: the Apotheosis of Rationality or the Magic of Life?". In this second part of her essay, attention is paid to a special case of

show abstract

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

Zhong

Luo

Zhou

et al. 2022

J of Applied Toxicology

View full text Add to dashboard Cite

Abnormal ovarian function is the main manifestation of female reproductive toxicity. Granulosa cells (GCs) play an important role in determining the fate of follicles and are the main effector cells of the female reproductive system. Excessive apoptosis of GCs leads to pathological folliculogenesis and further reproductive damage. However, drugs available for treatment of female reproductive toxicity are limited. Recent studies have confirmed that various natural products and bioactive ingredients of traditional Chinese medicine (TCM) can inhibit apoptosis of GCs and protect ovarian function. In this review, the mechanisms underlying the proapoptotic and antiapoptotic effects of natural products and bioactive ingredients of TCM on the proliferation, function, and apoptosis of GCs are summarized based on the findings of reports published over the past 10 years as reference for the treatment of female reproductive toxicity.

show abstract

The inhibitory influence of toluene on mare ovarian granulosa cells can be prevented by fennel

Cited by 12 publications

References 21 publications

Toluene Can Disrupt Rat Ovarian Follicullogenesis and Steroidogenesis and Induce Both Autophagy and Apoptosis

Toluene Can Disrupt Rat Ovarian Follicullogenesis and Steroidogenesis and Induce Both Autophagy and Apoptosis

Untitled

The effects of natural products and bioactive ingredients of traditional Chinese medicine on apoptosis of ovarian granulosa cells

Contact Info

Product

Resources

About