“…Interestingly, we did not observe any flare of bullous disease after the first or second dose of anti-COVID-19 vaccination. 4 The pathogenesis should be explained by molecular mimicry between basement membrane-specific proteins (e.g., BP-180 and BP-230) and SARS-CoV-2 spike protein, that is used by the virus to bind and fuse with host cells. 5 Some authors however suggested that the vaccine may induce a great immunological response in individuals with immunological predisposition and consequent production of antibodies 6 ; this explanation match with the two cases observed in patients not previously affected by bullous diseases.…”