The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia

Perego, Ugo A.; Angerhofer, Norman; Pala, Maria; Olivieri, Anna; Lancioni, Hovirag; Kashani, Baharak Hooshiar; Carossa, Valeria; Ekins, Jayne E.; Gómez-Carballa, Alberto; Huber, Gabriela; Zimmermann, Bettina; Corach, Daniel; Babudri, Nora; Panara, Fausto; Myres, Natalie M.; Parson, Walther; Semino, Ornella; Salas, Antonio; Woodward, Scott R.; Achilli, Alessandro; Torroni, Antonio

doi:10.1101/gr.109231.110

Cited by 163 publications

(221 citation statements)

References 40 publications

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“…group A, C, and D lineages in the pre-Hispanic Maya were consistent with the hypothesis that the direct ancestors of Native Americans were a hybrid of different Siberian groups that had migrated to eastern Beringia at different times and following different routes (Figure 4) (Kunz and Reanier 1994;Perego et al, 2010;Starikovskaya et al 2005). …”

Section: Network Analysis For Haplogroup Dsupporting

confidence: 86%

Genetic Affiliation of Pre-Hispanic and Contemporary Mayas through Maternal Linage

Ochoa-Lugo¹,

Muñoz²,

Pérez-Ramírez³

et al. 2016

Human Biology

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Maya civilization developed in Mesoamerica and encompassed the Yucatan Peninsula, Guatemala, Belize, part of the Mexican states of Tabasco and Chiapas, and the western parts of Honduras and El Salvador. This civilization persisted approximately 3,000 years and was one of the most advanced of its time, possessing the only known full writing system at the time, as well as art, sophisticated architecture, and mathematical and astronomical systems. This civilization reached the apex of its power and influence during the Preclassic period, from 2000 BCE to 250 CE. Genetic variation in the pre-Hispanic Mayas from archaeological sites in the Mexican states of Yucatan, Chiapas, Quintana Roo, and Tabasco and their relationship with the contemporary communities in these regions have not been previously studied. Consequently, the principal aim of this study was to determine mitochondrial DNA (mtDNA) variation in the pre-Hispanic Maya population and to assess the relationship of these individuals with contemporary Mesoamerican Maya and populations from Asia, Beringia, and North, Central, and South America. Our results revealed interactions and gene flow between populations in the different archaeological sites assessed in this study. The mtDNA haplogroup frequency in the pre-Hispanic Maya population (60.53%, 34.21%, and 5.26% for haplogroups A, C, and D, respectively) was similar to that of most Mexican and Guatemalan Maya populations, with haplogroup A exhibiting the highest frequency. Haplogroup B most likely arrived independently and mixed with populations carrying haplogroups A and C based on its absence in the pre-Hispanic Mexican Maya populations and low frequencies in most Mexican and Guatemalan Maya populations, although this also may be due to drift. Maya and Ciboneys sharing haplotype H10 belonged to haplogroup C1 and haplotype H4 of haplogroup D, suggesting shared regional haplotypes. This may indicate a shared genetic ancestry, suggesting more regional interaction between populations in the circum-Caribbean region than previously demonstrated. Haplotype sharing between the pre-Hispanic Maya and the indigenous populations from Asia, the Aleutian Islands, and North, Maternal Lineage in Pre-Hispanic and Contemporary Mayas ■ 137Central, and South America provides evidence for gene flow from the ancestral Amerindian population of the pre-Hispanic Maya to Central and South America.

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Section: Network Analysis For Haplogroup Dsupporting

confidence: 86%

Genetic Affiliation of Pre-Hispanic and Contemporary Mayas through Maternal Linage

Ochoa-Lugo¹,

Muñoz²,

Pérez-Ramírez³

et al. 2016

Human Biology

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“…20 In addition, complete mtDNA genome studies have shown that all pan-American mtDNA haplogroups reveal entry times of 15-18 Ka, which are suggestive of a concomitant post-Last Glacial Maximum arrival from Beringia with early Amerindians. [39][40][41][42] As for the question whether the Q1a3*-M346 was present in South Siberia in the post-Last Glacial Maximum, we can report that divergence time estimate for South Siberian versus Chinese/North Pakistan Q1a3*-M346 haplotypes is 15.29 ± 5.49 Ka, thus supporting the idea for the real presence of Q1a3*-M346 in South Siberia in those times.…”

Section: Discussionsupporting

confidence: 64%

Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a

et al. 2011

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“…El avance en las técnicas de análisis molecular que ha tenido lugar en los últimos años ha permitido superar la clásica distinción de cinco haplogrupos (hgs) nativos de América (A, B, C, D y X), identificándose actualmente por lo menos 13 subhaplogrupos que ya estaban diferenciados al momento de ingreso al continente americano (Tamm et al 2007;Malhi et al 2010;Perego et al 2010;Kumar et al 2011), algunos de los cuales presentan patrones de distribución que darían cuenta de distintas rutas de poblamiento, como el caso de D4h3a que se distribuye casi exclusivamente en el oeste del continente, desde Alaska hasta Tierra del Fuego y se asocia con un poblamiento por costa pacífica (Perego et al 2009). Asimismo, al interior de cada subhaplogrupo se está avanzando en la definición de clados con distribuciones geográficas acotadas, que se habrían diferenciado localmente (Gayà-Vidal et al 2011;Bodner et al 2012;de Saint Pierre et al 2012a,b;García et al 2012;Motti, 2012;Taboada-Echalar et al 2013).…”

Section: Antecedentes En Estudios De Adn Mitocondrialunclassified

Primer genoma mitocondrial en restos humanos de la Costa de Santa Cruz, Argentina

et al. 2015

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RESUMENEn este trabajo se presenta la secuencia completa de ADN mitocondrial, obtenida a partir de restos óseos de un hombre adulto, hallado en el sitio Cañadón Misioneros (provincia de Santa Cruz, Argentina), con una antigüedad de 70 ± 30 años antes del presente. La secuencia corresponde al haplogrupo (hg) D4h3a5, nativo de América y exclusivo del sur de Patagonia, donde ha sido descripto tanto en muestras antiguas como actuales. Esta secuencia constituye el primer dato de ADN mitocondrial en la costa atlántica de Patagonia con la resolución suficiente para definir a nivel de subhaplogrupo. Se discuten las implicancias en cuanto a los vínculos biológicos de las poblaciones que habitaron esa porción del espacio patagónico en el marco de la información genética y arqueológica disponible.PALABRAS CLAVE: ADN mitocondrial, ADN antiguo, Nativos Americanos FIRST COMPLETE MITOCHONDRIAL GENOME SEQUENCE FROM HUMAN SKELETAL REMAINS OF THE COAST OF SANTA CRUZ, ARGENTINA ABSTRACTWe describe the complete mitochondrial genome sequence of an adult male skeleton, discovered at Cañadón Misioneros (Santa Cruz Province, Argentina), and dated 70 ± 30 years before present. The DNA sequence corresponded to haplogroup D4h3a5, native to the Americas and exclusive to the south of Patagonia, where it has been observed both in ancient and present-day individuals. This is the first mitochondrial DNA data of the Atlantic coast of Patagonia of sufficient

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The initial peopling of the Americas: A growing number of founding mitochondrial genomes from Beringia

Cited by 163 publications

References 40 publications

Genetic Affiliation of Pre-Hispanic and Contemporary Mayas through Maternal Linage

Genetic Affiliation of Pre-Hispanic and Contemporary Mayas through Maternal Linage

Ancient links between Siberians and Native Americans revealed by subtyping the Y chromosome haplogroup Q1a

Primer genoma mitocondrial en restos humanos de la Costa de Santa Cruz, Argentina

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