The injection of chemicals into the yolk sac of fertile eggs prior to incubation as a toxicity test

McLaughlin, Joseph; Marliac, Jean-Pierre; Verrette, M.Jacqueline; Mutchler, Mary K.; Fitzhugh, O. Garth

doi:10.1016/0041-008x(63)90068-1

Cited by 214 publications

(49 citation statements)

References 5 publications

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“…Peakall (18) reported that ring dove (Streptopelia risoria) eggs taken from birds given 10 ppm Aroclor 1254 in the diet averaged 4.8141.08 ppm standard error. The actual amounts in mg of PCBs in ring dove (18), mallard (8), and pheasant eggs in the present study would be far below the 10 mg injected by McLaughlin et al (6) into chicken eggs. The 10 mg resulted in poor hatchability, edema, and beak deformation.…”

Section: Effects On Behaviorcontrasting

confidence: 62%

See 1 more Smart Citation

Polychlorinated Biphenyls: Their Effects on Penned Pheasants

Dahlgren¹,

Linder²,

Carlson³

1972

Environ Health Perspect

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Section: Effects On Behaviorcontrasting

confidence: 62%

“…(9) found that PCBs deposited in chicken eggs were less than 0.5 ppm after 8 weeks with 0.5 and 1.0 ppm Aroclor 1248 in the diet. They found levels of over 3 ppm after 8 weeks with 10 ppm in the diet and levels of about [6][7] guillemot, (Uria aalge) eggs from the Baltic Sea.…”

Section: Effects On Behaviormentioning

confidence: 99%

Polychlorinated Biphenyls: Their Effects on Penned Pheasants

Dahlgren¹,

Linder²,

Carlson³

1972

Environ Health Perspect

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“…A total of 50 pmol TCDD (ULTRA Scientific, RI, USA) was dissolved in 5 µl of corn oil and injected into the yolk prior to incubation as previously described (Mclaughlin et al 1963, Walker et al 1997, Heid et al 2001. Additionally, eggs were injected into air cells with 10 µg NS398 (Cayman Chemical, MI, USA) dissolved in 12.5 µl of 50% dimethylsulfoxide (DMSO; DMSO:…”

Section: Animals and Treatmentsmentioning

confidence: 99%

TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398

et al. 2014

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Halogenated aromatic hydrocarbons (HAHs), including 2, 3, 7,, are known to cause severe heart defects in avian species. However, the mechanism of TCDD-induced chick cardiovascular toxicity is unclear. In this study, we investigated cyclooxygenase-2 (COX-2) as a possible mechanism of TCDD-induced cardiotoxicity. Fertile chicken eggs were injected with TCDD and a COX-2 selective inhibitor, NS398, and we investigated chick heart failure on day 10. We found that the chick heart to body weight ratio and atrial natriuretic factor (ANF) mRNA expression were increased but this increase was abolished with treatment of NS398. In addition, the morphological abnormality of an enlarged ventricle resulting from TCDD exposure was also abolished with co-treatment of TCDD and NS398. Our results suggested that TCDD-induced chick heart defects are mediated via the nongenomic pathway and that they do not require the genomic pathway.

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“…Edema and beak deformities in chicken embryos have been described after yolk-sac injection of 10 and 25 mg 42% chlorinated Aroclor, resulting in respectively 95 and 100% embryonic mortality (38).…”

Section: Other Effectsmentioning

confidence: 99%

Toxicology of PCBs for Mammals and for Birds

Vos¹

1972

Environmental Health Perspectives

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IntroductonIn the early days of its use, little work was done on the toxicology of the PCBs, and this was only in relation to the risks of occupational exposure. As will be shown many more studies were made as soon as it appeared that the extremely stable PCB's became a threat to the environment and its wildlife, and accidents occurred of acute poisoning in man and animals. These studies have been made with material with different contents of chlorine, from different manufacture, and-as we can now say in retrospect-with different and unknown contents of toxic impurities. For this reason the toxicological information of PCB's is difficult to summarize, but since the character of some important impurities has recently been elucidated, it is well to discuss these first in order to be able to consider their contribution to the overall toxicity of the different preparations studied.These studies were started because of the analogy between the effects of the PCBs (1-6) and some toxic effects associated with toxic factors in crude chlorophenols and in "toxic fat". Effects of the latter are liver damage (7), chloracne (7,8) and edema formation (9).

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The injection of chemicals into the yolk sac of fertile eggs prior to incubation as a toxicity test

Cited by 214 publications

References 5 publications

Polychlorinated Biphenyls: Their Effects on Penned Pheasants

Polychlorinated Biphenyls: Their Effects on Penned Pheasants

TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398

Toxicology of PCBs for Mammals and for Birds

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