The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis

Lazenby, M.G.; Crook, Martin

doi:10.1042/cs20100098

Cited by 8 publications

(6 citation statements)

References 53 publications

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“…This include the gene sets caries pulp up, cell adhesion molecules, monocyte dend DN, and cytokine-cytokine receptor interaction with caries pulp up as the most significantly upregulated gene set. Interestingly, there is an increasing evidence supporting an association between periodontitis and diabetic complications [29,30] suggesting that genes related to periodontitis could play a role for the development of diabetic vasculopathy. Because the tissue in our study is without atherosclerosis and cellular infiltration, it seems that the vascular smooth muscle cells themselves may express an inflammatory phenotype.…”

Section: Discussionmentioning

confidence: 99%

Global gene expression profiling displays a network of dysregulated genes in non-atherosclerotic arterial tissue from patients with type 2 diabetes

Skov

Knudsen

Olesen

et al. 2012

Cardiovasc Diabetol

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BackgroundGeneralized arterial alterations, such as endothelial dysfunction, medial matrix accumulations, and calcifications are associated with type 2 diabetes (T2D). These changes may render the vessel wall more susceptible to injury; however, the molecular characteristics of such diffuse pre-atherosclerotic changes in diabetes are only superficially known.MethodsTo identify the molecular alterations of the generalized arterial disease in T2D, DNA microarrays were applied to examine gene expression changes in normal-appearing, non-atherosclerotic arterial tissue from 10 diabetic and 11 age-matched non-diabetic men scheduled for a coronary by-pass operation. Gene expression changes were integrated with GO-Elite, GSEA, and Cytoscape to identify significant biological pathways and networks.ResultsGlobal pathway analysis revealed differential expression of gene-sets representing matrix metabolism, triglyceride synthesis, inflammation, insulin signaling, and apoptosis. The network analysis showed a significant cluster of dysregulated genes coding for both intra- and extra-cellular proteins associated with vascular cell functions together with genes related to insulin signaling and matrix remodeling.ConclusionsOur results identify pathways and networks involved in the diffuse vasculopathy present in non-atherosclerotic arterial tissue in patients with T2D and confirmed previously observed mRNA-alterations. These abnormalities may play a role for the arterial response to injury and putatively for the accelerated atherogenesis among patients with diabetes.

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Section: Discussionmentioning

confidence: 99%

Global gene expression profiling displays a network of dysregulated genes in non-atherosclerotic arterial tissue from patients with type 2 diabetes

Skov

Knudsen

Olesen

et al. 2012

Cardiovasc Diabetol

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“…Some researchers 14 suggested that improvement of the periodontal condition would positively affect metabolic control, while in other studies this positive effect was not evaluated. 15 Solidarity of universal pathogenetic mechanisms of inflammatory periodontal affection development, especially in patients with the metabolic syndrome, requires a complex, dynamic assessment of cytokine metabolism in this group of patients.…”

Section: Discussionmentioning

confidence: 99%

Unicystic ameloblastoma of mandible: imaging features and literature review

Bhayya¹,

Ml²,

Paramkusam³

et al. 2018

JDHODT

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status tends to change, thus leading to an increase in inflammation in the periodontal tissues.Dental health is an important component of somatic human health. Various aggressive environmental and nutritional factors affect adversely the oral cavity homeostasis, serve as a prerequisite for emergence of inflammatory-destructive diseases of the dentofacial system. Development of general periodontitis (GP) is accompanied by a complex of pathological changes with a predominance of inflammatory and dystrophic phenomena. 1 These changes vary much, depending on the intensity of the periodontal tissue affection, and reflect the processes of local inflammation and activation of the immune defense mechanisms. All this requires adequate measures to control dental health of the population. 2 Diseases of periodontal tissues remain one of the urgent problems in the modern dentistry. 3 In recent decades, a large number of studies have been devoted to the relationship between the intensity of the periodontal complex affection and a number of somatic diseases, which are currently classified as socially significant ones. These are, first of all, cardiovascular diseases (CVD), diabetes mellitus, oncopathology, osteoporosis, osteoarthrosis, etc. 2,[4][5][6][7] In the industrialized countries the prevalence of metabolic syndrome among the population of 30years and older is 10-20%, significantly increasing with age. Goal of the studyidentifying the correlation of the cytokine status, arterial stiffness and oral health status in patients with the metabolic syndrome.

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“…Polymorphonuclear leukocytes and alterations in the collagen metabolism could be another possible reason for higher predisposition of T2DM patients towards periodontal diseases. The formation of AGEs may influence the collagen stability and vascular integrity and could also aggregate macrophage and monocyte receptors, thereby aggravating the susceptibility to periodontitis through the stimulation of IL-1 and TNF- α [ 13 ] ( Figure 2 ). These inflammatory cytokines are known to stimulate the insulin resistance and several other chronic inflammatory complications including periodontitis [ 14 ].…”

Section: Periodontitis and Obesity/diabetes: The Two-way Complicatmentioning

confidence: 99%

The Two‐Way Association of Periodontal Infection with Systemic Disorders: An Overview

Nagpal

Yamashiro

Izumi

2015

Mediators of Inflammation

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Oral cavity that harbors diverse bacterial populations could also act as a site of origin for spread of pathogenic microorganisms to different body sites, particularly in immunocompromised hosts, patients, the elderly, or the underprivileged. A number of recent publications have advocated that patients with periodontal diseases are more susceptible to metabolic endotoxemia, inflammation, obesity, type 2 diabetes, and other related systemic complications, concluding that periodontal diseases could be a potential contributing risk factor for a wide array of clinically important systemic diseases. However, despite a significant increase in the prevalence of periodontal infections and systemic diseases in the past few decades, the fundamental biological mechanisms of connection between these ailments are still not fully explicated. Consequently, the mechanisms by which this bidirectional damage occurs are being explored with a concentric vision to develop strategies that could prevent or control the complications of these ailments. This paper attempts to summarize and hypothesize the diverse mechanisms that hint to a certain connection between the two prevalent chronic situations.

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The innate immune system and diabetes mellitus: the relevance of periodontitis? A hypothesis

Cited by 8 publications

References 53 publications

Global gene expression profiling displays a network of dysregulated genes in non-atherosclerotic arterial tissue from patients with type 2 diabetes

Global gene expression profiling displays a network of dysregulated genes in non-atherosclerotic arterial tissue from patients with type 2 diabetes

Unicystic ameloblastoma of mandible: imaging features and literature review

The Two‐Way Association of Periodontal Infection with Systemic Disorders: An Overview

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