The innervation and structure of the conductive system of the human heart

Stotler, W. A.; McMahon, Riley

doi:10.1002/cne.900870202

Cited by 35 publications

(6 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thus, it is unlikely that the cardiac impulse is transmitted from the atria to the ventricles by the nerves in the atrio-ventricular bundle as Wilson (1909), Morison (1912), Holmes (1921), andField (1951) have suggested; these authors found many nerve trunks within the atrio-ventricular bundle in several species and considered that the musculature of the bundle was merely a highway for the nerves that passed into the ventricular myocardium. In contrast with the above-mentioned authors, Stotler and McMahon (1947), who investigated the heart in man and dog, indicated that the nerves entering the bundle from the adjacent atrio-ventricular node terminated within the bundle itself without passing to the general myocardium and they thus emphasized the exclusiveness of the bundle innervation. Such a distribution suggests that the nerves in the atrio-ventricular connecting system are concerned with regulating the speed and frequency of muscular conduction rather than with actually transmitting the cardiac impulse.…”

mentioning

confidence: 76%

Development of the nerve supply to the human heart.

Navaratnam¹

1965

Heart

View full text Add to dashboard Cite

mentioning

confidence: 76%

Development of the nerve supply to the human heart.

Navaratnam¹

1965

Heart

View full text Add to dashboard Cite

“…Considerable anatomical evidence exists for the presence of cholinergic receptors in the ventricles (11)(12)(13)(14)(15)(16)(17). Furthermore, acetylcholinesterase activity has…”

Section: Discussionmentioning

confidence: 99%

Effects of Acetylcholine on Automaticity and Conduction in the Proximal Portion of the His-Purkinje Specialized Conduction System of the Dog

Bailey

Greenspan

Elizari

et al. 1972

Circulation Research

View full text Add to dashboard Cite

Conventional intracellular recordings from the bundle of His and right bundle branch of the canine heart demonstrated that the slope of diastolic depolarization is markedly depressed by superfusion with relatively small concentrations (4-8 jug/ml) of acetylcholine. As the cells become less automatic, take-off potential increases, rise time of phase 0 is reduced, action potential amplitude increases, and conduction proceeds more rapidly.KEY WORDS right bundle branch determinants of conductivity spontaneous phase 4 depolarization transmembrane action potential innervation of the heart • Early investigations indicated that cells of the specialized conduction system below the atrioventricular (AV) junction are unaffected by small concentrations of acetylcholine (1). Specifically, the slope of spontaneous phase 4 depolarization from cells of the bundle of His, bundle branches, and peripheral Purkinje fibers is reported to be essentially unchanged by the infusion of acetylcholine. A method of exposing the entire proximal portion of the specialized AV conduction system of the canine heart in vitro was devised by one of the authors (M.V.E.), and the regular observation of automaticity afforded the opportunity to reexamine certain aspects of this property.From the Krannert Institute of Cardiology, Marion County General Hospital, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.This work was supported in part by U. S. Public Health Service Grants HE-6308, HTS-5363, and HE-5749 from the National Heart Institute and by the Herman C. Krannert Fund, the Indiana Heart Association, and the AMA Committee for Research on Tobacco and Health. Drs. Bailey, Elizari, and Anderson are U. S. Public Health Service Trainees in Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202.Received July 30, 1971. Accepted for publication November 29, 1971. The purpose of this paper is to report our studies of the effects of small doses of acetylcholine on spontaneity and conduction within the proximal portion of the HisPurkinje conduction pathways. MethodsAdult mongrel dogs of either sex weighing 15-20 kg were anesthetized with sodium pentobarbital (30 mg/kg, i.v.) and intubated; respiration was controlled with a Harvard respirometer. The hearts were excised rapidly through a right thoracotomy, and the portion of the septum containing the AV junction, the bundle of His, and both bundle branches was removed, placed in a Lucite muscle chamber, and superfused with oxygenated Tyrode's solution maintained at a temperature of 31 ± 0.2°C. Then the entire bundle of His was exposed from the nodal His (NH) region of the AV junction to the origins of both bundle branches. Portions of the proximal part of the specialized AV conduction system were isolated, when appropriate, by transection. The tissue was then allowed to stabilize for several hours until muscular contraction ceased and to minimize changes in diastolic depolarization as a function of time and in...

show abstract

“…The third aspect refers to two analogies that appear to exist between the baroreceptor influence on the atrioventricular and sinoatrial nodes. One is that both these structures are influenced by the baroreceptors largely through the vagi (Eckberg et al, 1972;Pickering et al, 1972a;Eckberg et al, 1976;Leon et al, 1970), although either of them possesses a pronounced sympathetic innervation (Stoler and McMahon, 1947). The other analogy, which is illustrated in Figure 7, shows that the shortening in A-H interval obtained with reduction in baroreceptor activity below the existing level is less than the lengthening obtained with an increase in baroreceptor activity above the existing level, an asymmetry that can be clearly demonstrated also for the baroreceptor effects on the R-R interval (see also Pickering et al, 1972b;Mancia et al, 1977).…”

Section: Figure 4 Effects Oftrinitroglycerin-induced Decreases In Meamentioning

confidence: 99%

Baroreceptor control of atrioventricular conduction in man.

Mancia

Bonazzi

Pozzoni

et al. 1979

Circulation Research

View full text Add to dashboard Cite

Although human baroreflexes are known to exert a powerful physiological control on heart rate, little information exists on the physiological control they exert on the atrioventricular conduction system. In 11 normotensive subjects with normal atrioventricular conduction, we altered baroreceptor activity by injection of pressor and depressor drugs (phenylephrine and trinitroglycerin) and recorded mean arterial pressure (MAP, catheter measurements), R-R interval, and pre-His and post-His intervals (A-H and H-V, His bundle recording). With the subjects in sinus rhythm, increasing MAP by 21+/- 1 mm Hg caused a marked lengthening (250 +/- 28 msec), and decreasing MAP by 17 +/- 2 mm Hg a marked shortening (142 +/- 16 msec) of the R-R interval. There was little change in the A-H interval and no change at all in the H-V interval. However, when the R-R interval was kept constant in these subjects by atrial pacing, a similar increase and decrease in MAP caused, respectively, a marked lengthening (49 +/- 6 msec) and shortening (19 +/- 3 msec) of the A-H interval, although the H-V interval remained unaffected. Thus physiological ranges of baroreceptor activation have a marked influence on the atrioventricular node but apparently not on the ventricular portion of the atrioventricular conduction system. This influence is unmasked when pacing prevents the baroreceptor influence on the sinoatrial node.

show abstract

The innervation and structure of the conductive system of the human heart

Cited by 35 publications

References 11 publications

Development of the nerve supply to the human heart.

Development of the nerve supply to the human heart.

Effects of Acetylcholine on Automaticity and Conduction in the Proximal Portion of the His-Purkinje Specialized Conduction System of the Dog

Baroreceptor control of atrioventricular conduction in man.

Contact Info

Product

Resources

About