The innovative approach to combat cancer: Liquid biopsy and immunotherapy

Abstract

Liquid biopsy, as an advanced examination approach, has revealed its powerful function, since it could monitor development of cancer synchronously. Sampling for liquid biopsy usually is blood, so the sampling is feasible, non-invasive and repetitively, which overcomes traumatically sampling of conventional biopsy. Moreover, immunotherapy is considered as a novel treatment of cancer. It aims to enhance the immune system response to cancer. One of immunotherapy called chimeric antigen receptor T cell therapy (CAR-T) has accomplished great success in cancer treatment. The data from recent study has shown the remarkable antitumor activity of CAR-T to hematologic malignancies. Therefore, this review summarized the principles of liquid biopsy and the evaluation of liquid biopsy. Also, the review introduced immunotherapy, general mechanism of CRT-T, structure of CAR and its limitations.