The ‘ins and outs’ of faecal microbiota transplant for recurrent Clostridium difficile diarrhoea at Wits Donald Gordon Medical Centre, Johannesburg, South Africa

Abstract

This case series confirms that FMT is a safe and effective therapy for recurrent CDAD. In most cases it can be administered via the nasogastric route in the outpatient department. We propose that the recently published South African Gastroenterology Society guidelines be reviewed with regard to recommendations for the route of administration of FMT and hospital admission. Meticulous prescription practice by clinicians practising in hospitals and outpatient settings, with particular attention to antimicrobials and chronic medication, is urgently required to prevent this debilitating and potentially life-threatening condition.

The case for stool banks in South Africa

“…Although experiences with FMT in SA are mostly unknown, a recent study from Johannesburg demonstrated that at least 70% of donors were close relatives. [9] The article highlights the multiple challenges we face, including the pertinent discussion on what constitutes an ideal donor and the minimal screening tests required for all stool donors in SA. To date, there have been no trials evaluating outcomes of faecal transplant in relation to donor characteristics.…”