The ins and outs of macrophages in tissue repair

Tissue Location Drives the Metabolic Re-Profiling of Macrophages

“…One, albeit far Nevertheless, further work determining M(IL-4) polarisation in response to different doses of glucose, as well as other metabolites, will be crucial to validate these observations and to further understand the implications of metabolite availability in shaping tissue macrophage responsiveness in vivo. One of the questions emerging from the work of The importance of work addressing the role of the niche factors in macrophage polarisation is highlighted by the increasing interest in targeting macrophages to promote wound repair, improve infection outcomes or prevent fibrosis[12,28]. As we develop a greater understanding of macrophage metabolism and how it shapes the response of these cells, we may also be able to harness immunometabolism for therapeutic purposes[19,29,30].…”