2023
DOI: 10.3390/biology12070990
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The Ins and Outs of Endosteal Niche Disruption in the Bone Marrow: Relevance for Myeloma Oncogenesis

Abstract: Multiple Myeloma (MM) and its preexisting stage, termed Monoclonal Gammopathy of Undetermined Significance (MGUS), have long been considered mainly as genomic diseases. However, the bone changes observed in both conditions have led to a reassessment of the role of the bone microenvironment, mainly the endosteal niche in their genesis. Here, we consider the disruption of the endosteal niche in the bone marrow, that is, the shift of the endosteal niche from an osteoblastic to an osteoclastic profile produced by … Show more

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Cited by 3 publications
(2 citation statements)
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“…This process due to genetic mosaicism would be one of the possible sources of disruption of cellular interactions and communications within the tissue from which cancer can originate, together with nongenetic factors (carcinogenic agents acting on cellular interactions and communications, inflammaging, etc.). Altogether, these genetic and nongenetic factors affecting the microenvironment are possible causes of increased cellular stochasticity and transformation of the future cancer cells according to the previously proposed Tissue-Disruption induced cellular Stochasticity (TiDiS) theory [45,46,50,51] (see below). Moreover, cancers cannot only be initiated but also boosted and promoted by IGEs, which can also occur later during tumor development.…”
Section: An Evolutionary Scenario Through Igesmentioning
confidence: 99%
“…This process due to genetic mosaicism would be one of the possible sources of disruption of cellular interactions and communications within the tissue from which cancer can originate, together with nongenetic factors (carcinogenic agents acting on cellular interactions and communications, inflammaging, etc.). Altogether, these genetic and nongenetic factors affecting the microenvironment are possible causes of increased cellular stochasticity and transformation of the future cancer cells according to the previously proposed Tissue-Disruption induced cellular Stochasticity (TiDiS) theory [45,46,50,51] (see below). Moreover, cancers cannot only be initiated but also boosted and promoted by IGEs, which can also occur later during tumor development.…”
Section: An Evolutionary Scenario Through Igesmentioning
confidence: 99%
“…In a healthy individual, bone homeostasis is maintained through the continuous resorption of old bone, which is followed by the coupled refilling (formation) of new bone within the bone resorption cavity. Myeloma bone disease arises in patients with MM due to uncoupled bone remodeling with upregulated osteoclast and downregulated osteoblast activity [9][10][11]. The receptor activator of nuclear factor-κB (RANK), a transmembrane receptor expressed in several bone cells as well as in hematopoietic osteoclast precursor cells, activates upon binding with RANK-Ligand (RANKL) and facilitates pre-osteoclast recruitment and osteoclast activation and survival [12].…”
Section: Antiresorptive Treatmentsmentioning
confidence: 99%