The insertion-deletion polymorphism of the <i>ACE</i> gene is associated with increased blood pressure in women at the end of pregnancy

Reshetnikov, Evgeny; Akulova, L Y; Добродомова, И. С.; Dvornyk, Volodymyr; Polonikov, Alexey; Churnosov, Mikhail

doi:10.1177/1470320313501217

Cited by 45 publications

(35 citation statements)

References 42 publications

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“…Finally, the response to vasodilation has primarily focused on genetic variation of the ACE-inhibitor, angiotensin, and the angiotensin-II receptor. Specifically, the deletion variant of ACE (rs7079), the C variant of Angiotensin (rs699), and the C variant of the angiotensin-II receptor (rs5186) have shown enhanced response to ACE-inhibition and angiotensin receptor antagonism [44][45][46]. Collectively, these data demonstrate genetic variation may be partially responsible for the variability in effectiveness to HTN therapy and, possibly, the bell-curve response noted previously.…”

Section: Resultsmentioning

confidence: 64%

Association of a Multi-Gene Panel with Blood Pressure Medication Success in Patients with Hypertension: A Pilot Study

Snyder¹,

Sprissler²,

Johnson³

et al. 2018

Preprint

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Several common and functional genes are known to contribute to responsiveness to blood pressure (BP) therapy. BP therapy is typically guided by algorithms that do not include a patient’s genetic information. This study aimed to determine the impact of a multi-organ genetic panel on BP response to pharmacotherapy. Eighty-six patients completed one study visit consisting of a buccal swab collection, measurement of office BP, and a medical chart review for BP history. Genes analyzed included those that encode for one drug metabolizing enzyme, renal Na+ handling, vascular, and cardiac function. Relationships between genotype and control of BP (<140/<90), ∆ systolic BP, ∆ diastolic BP, and ∆ mean arterial BP were assessed. SLC12A3 resulted in a significant association between the target drug and the functional genotype for BP control (<140/<90 cut off) (p<0.05). Conversely, three of five renal genotypes were associated with BP control using 120/80 as a cut-off (p<0.05). Three of four cardiac genotypes were associated with the BP control at <140/<90, with one being statistically significant (position 49 of ADRB1). Only one vascular genotype was predictive of blood pressure control at <140/<90. We found a significant drop in mean BP from baseline in six genes, three important in the diuretic response and three in β-blockade (p<0.05 on target drug vs. not). These results demonstrate that a multi-gene panel for renal Na+ handling, vascular function, and cardiac output may influence the BP response to therapy, but larger studies with more statistical power are needed.

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Section: Resultsmentioning

confidence: 64%

Association of a Multi-Gene Panel with Blood Pressure Medication Success in Patients with Hypertension: A Pilot Study

Snyder¹,

Sprissler²,

Johnson³

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Another study in a group of obese children and adolescents found that the DD and ID genotypes were associated with a higher prevalence of hypertension in boys but not in girls, compared to the II genotype [ 123 ]. The D allele of the ACE gene was also associated with higher BP in pregnant women [ 124 ]. However, other studies have failed to confi rm a signifi cant relation between ACE I/D polymorphism and the risk of hypertension (Chaps.…”

Section: Heterogeneity Of the Ace Genementioning

confidence: 96%

Sympathetic and Renin–Angiotensin Activity in the Pathophysiology of Hypertension

Covic

Segall

2015

Pathophysiology and Pharmacotherapy of Cardiovascular Disease

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The implication of the sympathetic nervous system (SNS) in the pathogenesis of essential hypertension has been suggested a long time ago, considering the major role played by this system in blood pressure (BP) regulation. Studies based on both global (e.g., plasma norepinephrine) and regional (norepinephrine spillover and microneurography) assessments of sympathetic activity have demonstrated that neurogenic mechanisms may be involved in up to 50 % of all cases of essential hypertension. In addition, renal sympathetic denervation has been shown to induce signifi cant and persistent decreases in BP. Moreover, there is evidence that sympathetic hyperactivity may contribute directly to target-organ damage, including cardiac hypertrophy, vascular remodeling, and renal dysfunction. The specifi c causes of sympathetic activation in essential hypertension are not entirely known, but genetic factors, high dietary salt intake, as well as several metabolic and neurohumoral abnormalities have been involved. In patients with obesity-and metabolic syndrome-associated hypertension, SNS overactivity may result from many factors, including hyperinsulinemia, hyperleptinemia, hypoadiponectinemia, hypoghrelinemia, and RAAS activation.The renin-angiotensin system (RAS) is another key regulator of BP and fl uid homeostasis. Ang II induces BP elevation by vasoconstriction of renal and systemic arterioles, stimulation of renal tubular sodium reabsorption, and release of aldosterone from the adrenal glands. Moreover, both Ang II (via AT 1 receptors) and aldosterone exert proinfl ammatory, profi brotic, and prooxidant effects on the cardiovascular system, contributing to myocardial hypertrophy and fi brosis, vascular remodeling and calcifi cation, cerebrovascular damage, and renal glomerular and tubulointerstitial injury. In contrast, other components of the RAS, including mainly the AT 2 receptors and the ACE2/Ang-(1-7)/Mas axis, counteract most of the negative cardiovascular effects of the Ang II/AT 1 /aldosterone system and might play a compensatory role in hypertension.

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“…There is a large number of works devoted to the study of genetic susceptibility to various pathologies. The search for the associations of polymorphic genetic loci with a disease is widely used currently (3,(7)(8)(9)(10)12).…”

Section: Introductionmentioning

confidence: 99%

Assessment of psycho-emotional state of student with Mitral regurgitation and possible ways of its pharmacological correction

et al. 2019

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The article presents the results of psycho-emotional state assessment a person with Mitral regurgitation when he lies using the device for the physiological parameter record, and the possible ways of its pharmacological correction are offered. 77.5% of the subjects demonstrated the changes in the psycho-emotional state during some lie (the increase of heart rate made 10-30 beats relative to the norm, the increase of blood pressure and dilated pupils), the decrease of T wave amplitude was observed among 56% on the electrocardiogram, some of the subjects (18%) had a noticeable change of face color, mild tachycardia (79.5%), the change in the ratio of the electroencephalogram basic rhythms (87%). 5% of the subjects had a very strong tachycardia and pressure increase at the moment of stress, there were significant changes in the electrocardiogram. These students with Mitral regurgitations are recommended to conduct pharmacological correction of psycho-emotional state.

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The insertion-deletion polymorphism of the ACE gene is associated with increased blood pressure in women at the end of pregnancy

Cited by 45 publications

References 42 publications

Association of a Multi-Gene Panel with Blood Pressure Medication Success in Patients with Hypertension: A Pilot Study

Association of a Multi-Gene Panel with Blood Pressure Medication Success in Patients with Hypertension: A Pilot Study

Sympathetic and Renin–Angiotensin Activity in the Pathophysiology of Hypertension

Assessment of psycho-emotional state of student with Mitral regurgitation and possible ways of its pharmacological correction

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