The Instrumental Activities of Daily Living in Parkinson’s Disease Patients Treated by Subthalamic Deep Brain Stimulation

Bezdíček, Ondřej; Mana, Josef; Růžička, Filip; Havlík, Filip; Fečíková, Anna; Uhrová, Tereza; Růžička, Evžen; Urgošík, Dušan; Jech, Robert

doi:10.3389/fnagi.2022.886491

Cited by 3 publications

(2 citation statements)

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“…This study is consistent with previous studies regarding improving motor and quality of life ( Fasano et al, 2010 ; Lahtinen et al, 2020 ; Bove et al, 2021 ; Bezdicek et al, 2022 ; Golfrè Andreasi et al, 2022 ; Zeng et al, 2023 ). It is shown that postoperative Med-off treatment with only STN-DBS improved PD motor compared with preoperative Med-off status.…”

Section: Discussionsupporting

confidence: 93%

Effects of STN-DBS on cognition and mood in young-onset Parkinson’s disease: a two-year follow-up

Hong,

Xie,

Chen

et al. 2024

Front. Aging Neurosci.

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BackgroundThe effects of subthalamic nucleus deep brain stimulation (STN-DBS) on the cognition and mood of patients with PD are still not uniformly concluded, and young-onset Parkinson’s disease (YOPD) is even less explored.ObjectiveTo observe the effectiveness of STN-DBS on the cognition and mood of YOPD patients.MethodsA total of 27 subjects, with a mean age at onset of 39.48 ± 6.24 and age at surgery for STN-DBS of 48.44 ± 4.85, were followed up preoperatively and for 2 years postoperatively. Using the Unified Parkinson disease rating scale (UPDRS), H&Y(Hoehn and Yahr stage), 39-Item Parkinson’s Disease Questionnaire (PDQ-39), Mini-mental state examination (MMSE), Montreal Cognitive Assessment (MoCA), Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA) to assess motor, cognition, and mood.ResultsAt the 2-year follow-up after STN-DBS, YOPD patients showed significant improvements in motor and quality of life (UPDRS III: p < 0.001, PDQ-39: p < 0.001); overall cognition was not significantly different from preoperative (MMSE: p = 0.275, MoCA: p = 0.913), although language function was significantly impaired compared to preoperative (MMSE: p = 0.004, MoCA: p = 0.009); depression and anxiety symptoms also improved significantly (HAMD: p < 0.001, HAMA: p < 0.001) and the depression score correlated significantly with motor (preoperative: r = 0.493, p = 0.009), disease duration (preoperative: r = 0.519, p = 0.006; postoperative: r = 0.406, p = 0.036) and H&Y (preoperative: r = 0.430, p = 0.025; postoperative: r = 0.387, p = 0.046); total anxiety scores were also significantly correlated with motor (preoperative: r = 0.553, p = 0.003; postoperative: r = 0.444, p = 0.020), disease duration (preoperative: r = 0.417, p = 0.031), PDQ-39 (preoperative: r = 0.464, p = 0.015) and H&Y (preoperative: r = 0.440, p = 0.022; postoperative: r = 0.526, p = 0.005).ConclusionSTN-DBS is a safe and effective treatment for YOPD. The mood improved significantly, and overall cognition was not impaired, were only verbal fluency decreased but did not affect the improvement in quality of life.

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Section: Discussionsupporting

confidence: 93%

Effects of STN-DBS on cognition and mood in young-onset Parkinson’s disease: a two-year follow-up

Hong,

Xie,

Chen

et al. 2024

Front. Aging Neurosci.

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“…In this study, by using the correlation analysis of the patient's test index NSE and BI index, it is found that NSE is related to skillful activities such as feeding, dressing, toilet use. Bezdicek et al [21] found that the increase of NSE often represents a greater degree of brain damage and aggravation of symptoms in patients with Parkinson's disease, while the aggravation of central nervous system damage is often closely related to skilled activity, which is consistent with our results. Secondly, our clinical prediction model shows that there is a linear cor- The recuperation of patients' condition is indissociable from the meticulous nursing plan implemented by nursing personnel and the provision of comprehensive health education [22], which is derived from the enhancement of nurs-…”

Section: Discussionsupporting

confidence: 92%

Research on the Correlation between NSE Level and Activities of Daily Living in Parkinson’s Disease

He,

Zhu,

Che

et al. 2023

JBM

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Cognition and Activity of Daily Living Function in people with Parkinson’s disease

Bode,

Kalbe,

Liepelt-Scarfone

2024

J Neural Transm

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The ability to perform activities of daily living (ADL) function is a multifaceted construct that reflects functionality in different daily life situations. The loss of ADL function due to cognitive impairment is the core feature for the diagnosis of Parkinson’s disease dementia (PDD). In contrast to Alzheimer’s disease, ADL impairment in PD can be compromised by various factors, including motor and non-motor aspects. This narrative review summarizes the current state of knowledge on the association of cognition and ADL function in people with PD and introduces the concept of “cognitive ADL” impairment for those problems in everyday life that are associated with cognitive deterioration as their primary cause. Assessment of cognitive ADL impairment is challenging because self-ratings, informant-ratings, and performance-based assessments seldomly differentiate between “cognitive” and “motor” aspects of ADL. ADL function in PD is related to multiple cognitive domains, with attention, executive function, and memory being particularly relevant. Cognitive ADL impairment is characterized by behavioral anomalies such as trial-and-error behavior or task step omissions, and is associated with lower engagement in everyday behaviors, as suggested by physical activity levels and prolonged sedentary behavior. First evidence shows that physical and multi-domain interventions may improve ADL function, in general, but the evidence is confounded by motor aspects. Large multicenter randomized controlled trials with cognitive ADL function as primary outcome are needed to investigate which pharmacological and non-pharmacological interventions can effectively prevent or delay deterioration of cognitive ADL function, and ultimately the progression and conversion to PDD.

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The Instrumental Activities of Daily Living in Parkinson’s Disease Patients Treated by Subthalamic Deep Brain Stimulation

Cited by 3 publications

References 60 publications

Effects of STN-DBS on cognition and mood in young-onset Parkinson’s disease: a two-year follow-up

Effects of STN-DBS on cognition and mood in young-onset Parkinson’s disease: a two-year follow-up

Research on the Correlation between NSE Level and Activities of Daily Living in Parkinson’s Disease

Cognition and Activity of Daily Living Function in people with Parkinson’s disease

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