The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*

Hwa, Vivian; Oh, Youngman; Rosenfeld, Ron G.

doi:10.1210/edrv.20.6.0382

Cited by 453 publications

(317 citation statements)

References 203 publications

(284 reference statements)

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“…2 It can be seen from the CD results ( Fig. 2A) apparently significant differences in amplitude, the secondary structure estimates (given in Table I) are broadly similar, exhibiting a strong negative band with a minimum close to 200 nm in each case.…”

Section: Resultsmentioning

confidence: 64%

“…In turn, IGFs are regulated by a family of six IGF-binding proteins (IGFBPs) that form high affinity complexes with both IGF-I and IGF-II (reviewed in Ref. 2). Because the affinity constants of the IGFBPs are between 2-and 50-fold greater for binding IGFs than that of the IGF type 1 receptor, it is thought that the IGFBPs are able to regulate the bioavailability of IGFs in different biological fluids.…”

mentioning

confidence: 99%

“…IGFBPs are proteins of 216 -289 residues, and all share a common protein structure that can be conceptually divided up into three domains, where a domain may be defined as a region of a protein that can fold into a tertiary structure independent of neighboring sequences (2) (Fig. 1).…”

mentioning

confidence: 99%

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Specific Amino Acid Substitutions Determine the Differential Contribution of the N- and C-terminal Domains of Insulin-like Growth Factor (IGF)-binding Protein-5 in Binding IGF-I

Shand

Beattie

Song

et al. 2003

Journal of Biological Chemistry

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Section: Resultsmentioning

confidence: 64%

mentioning

confidence: 99%

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Specific Amino Acid Substitutions Determine the Differential Contribution of the N- and C-terminal Domains of Insulin-like Growth Factor (IGF)-binding Protein-5 in Binding IGF-I

Shand

Beattie

Song

et al. 2003

Journal of Biological Chemistry

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“…IGFBPs 1-6 are generally thought to consist of three structural domains of approximately equal length (4,5). All six IGFBPs are characterized by highly conserved cysteine-rich amino-and carboxyl-terminal domains, joined by a linker domain unique to each IGFBP species.…”

Section: Igfsmentioning

confidence: 99%

“…Although these fragments demonstrate IGF binding properties, there is a distinct loss of affinity, suggesting a requirement for additional components. Interestingly, IGFBPrelated proteins, which share sequence similarities with the amino-terminal domain of the high affinity IGFBPs, have also been reported to bind IGF-I, IGF-II, and insulin (4,(13)(14)(15).…”

Section: Igfsmentioning

confidence: 99%

BIAcore Analysis of Bovine Insulin-like Growth Factor (IGF)-binding Protein-2 Identifies Major IGF Binding Site Determinants in Both the Amino- and Carboxyl-terminal Domains

Carrick

Forbes

Wallace

2001

Journal of Biological Chemistry

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Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7

Sun

Cao

Guo

et al. 2022

Adv Materials Inter

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process resulting in capillary bed formation. [1,2] However, sprouting angiogenesis can proceed as an overshooting reaction that results in the formation of additional blood vessels, followed by delayed decelerating growth. [3] This decelerating phase occurs simultaneously with the regression of superfluous vessels at a later stage of healing so that vessel beds are pruned back to normal vascular density and vascular homeostasis is maintained; [4] this process is particularly important because uncontrolled vessel growth leads to pathological effects such as proliferative diabetic retinopathy, [5,6] and incorrect vascular patterning causes vessel instability and poor network functionality. [7] Therefore, organized angiogenesis deceleration at the later stage of healing is crucial for vessel normalization and stabilizing the mature vessels, ensuring that tissue regeneration including bone defect healing can be carried out within a controllable range; however, the mechanism behind this remains unclear. Alteration of extrinsic microenvironment, such as hypoxia improvement, is known as a common cause of capillary deceleration, [8,9] yet the decelerating angiogenesis response is usually accompanied by the repairing process of various injured tissue. [10] Therefore, it's reasonable to assume that intrinsic Deceleration of sprouting angiogenesis until its final disappearance after blood vessel reconstruction is crucial for controlled tissue repair; however, its underlying mechanism remains unclear. It is reported that osteogenic differentiated bone marrow stem cells (OD-BMSCs) contribute to sprouting angiogenesis deceleration by releasing intrinsic "OFF" signals. In vitro experiments show that insulin-like growth factor-binding protein 7 (IGFBP7) is the main component of OD-BMSCs paracrine products which could inhibit the tube formation ability of endothelial cells. In addition, cell functional experiments show that IGFBP7 inhibits sprouting angiogenesis by reducing cell migration and tip cell specification. Furthermore, it is found that early IGFBP7 intervention, which accelerates sprouting angiogenesis deceleration during the early stage of healing, impedes bone defect healing. These results demonstrate that OD-BMSCs could offer intrinsic inhibitory signals on sprouting angiogenesis and the appropriate emergence timing of these signals is crucial to maintain vasculature homeostasis during bone repairing. These results provide insight into the complex interaction between osteogenesis-angiogenesis coupling and suggest the potential therapeutic application of IGFBP7 in regulating vascular homeostasis.

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The Insulin-Like Growth Factor-Binding Protein (IGFBP) Superfamily*

Cited by 453 publications

References 203 publications

Specific Amino Acid Substitutions Determine the Differential Contribution of the N- and C-terminal Domains of Insulin-like Growth Factor (IGF)-binding Protein-5 in Binding IGF-I

Specific Amino Acid Substitutions Determine the Differential Contribution of the N- and C-terminal Domains of Insulin-like Growth Factor (IGF)-binding Protein-5 in Binding IGF-I

BIAcore Analysis of Bovine Insulin-like Growth Factor (IGF)-binding Protein-2 Identifies Major IGF Binding Site Determinants in Both the Amino- and Carboxyl-terminal Domains

Osteogenic Differentiated Human Bone Marrow Stem Cells Contribute to Sprouting Angiogenesis Deceleration via Paracrine Excreted IGFBP7

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