The Insulin Resistance Atherosclerosis Study (IRAS)

Wagenknecht, Lynne E.; Mayer, Elizabeth J.; Rewers, Marian; Haffner, Steven M.; Selby, Joseph V.; Borok, Gerald M.; Henkin, Leora; Howard, George; Savage, Peter J.; Saad, Mohammed F.; Bergman, Richard N.; Hamman, Richard F.

doi:10.1016/1047-2797(95)00062-3

Cited by 271 publications

(108 citation statements)

References 46 publications

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“…Potential probands of these families were identified from the community-based "parent study" (the IRAS [17]). Individuals reporting large family sizes were invited to participate with their relatives in the IRAS Family Study.…”

Section: Methodsmentioning

confidence: 99%

“…Indexes of glucose homeostasis were assessed by the frequently sampled intravenous glucose tolerance test (IVGTT) (19), with minimal model (MINMOD) analyses (20). Two modifications of the original protocol were employed, similar to that used in the original IRAS (17). An injection of insulin, rather than tolbutamide, was used to ensure adequate plasma insulin levels for the accurate computation of insulin resistance across a broad range of glucose tolerance (21), and a reduced sampling protocol requiring 12 (rather than 30) plasma samples (22) was used.…”

Section: Methodsmentioning

confidence: 99%

“…The IRAS Family Study is an extension of the IRAS (Insulin Resistance Atherosclerosis Study), the primary objective of which was to determine the relationship between a direct measure of insulin resistance and carotid atherosclerosis in 1,625 unrelated individuals in four communities (17,18). Families (Hispanic and African American) were ascertained on family size and not on extreme phenotype (e.g., diabetes).…”

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confidence: 99%

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Identification of Quantitative Trait Loci for Glucose Homeostasis

et al. 2004

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Genetic and environmental determinants play critical roles in insulin resistance and ␤-cell function. A model of the complex feedback system for maintenance of glucose tolerance has been developed that reflects the constraint of glycemia within narrow physiologic limits. The "glucose homeostasis" model is described by insulin sensitivity (S I ), glucose disposition (S G ), acute insulin response to glucose (AIR G ), and disposition index (DI). Relatively little is known about the genetic basis of glucose homeostasis phenotypes or their relationship to risk of diabetes and atherosclerotic cardiovascular disease. A genome scan for glucose homeostasis phenotypes in nondiabetic subjects has been carried out in African-American (n ‫؍‬ 21) and Hispanic (n ‫؍‬ 45) extended families as part of the IRAS Family Study. In African-American families, there was significant evidence for linkage of DI between D11S2371 and D11S2002 (logarithm of odds [LOD] ‫؍‬ 3.21) at 81 cM, and in the combined sample of African-American and Hispanic families, there was evidence at GATA117D01 (140 cM) on chromosome 11 (LOD ‫؍‬ 2.21). Evidence of linkage was also observed for S I in Hispanic (LOD ‫؍‬ 2.28, between D15S822 and GTTTT001) and AIR G in African-American families (LOD ‫؍‬ 2.73, between D4S1625 and D4S1629; and LOD ‫؍‬ 2.56 at PAH (phenylalanine hydroxylase) on chromosome 12). These results provide impetus for future positional cloning of quantitative trait loci (QTLs). Identifying genes in these regions should provide insight into the nature of the metabolic syndrome and diabetes, and facilitate the development of more effective therapies for prevention and treatment of diabetes and other diseases associated with disordered glucose metabolism.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

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Identification of Quantitative Trait Loci for Glucose Homeostasis

et al. 2004

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“…Three centers recruited and examined members of large families of Hispanic (San Antonio, TX, and San Luis Valley, CO) or African-American ethnicity (Los Angeles, CA) over a 2.5-year period (2000 -2002). Probands were identified from the parent study (the IRAS [8]) as those who had self-reported a large family structure on a family medical history questionnaire 2 years before this study. This collection was supplemented with large non-IRAS families recruited from the general population.…”

Section: Methodsmentioning

confidence: 99%

“…Insulin sensitivity was assessed by the frequently sampled intravenous glucose tolerance test (9) with minimal model analyses (10) as previously described (8). An injection of insulin was used to ensure adequate plasma insulin levels for the accurate computation of insulin resistance across a broad range of glucose tolerance (11).…”

Section: Methodsmentioning

confidence: 99%