The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial

Blanco-Rojo, Ruth; Alcalá‐Díaz, Juan F.; Wopereis, Suzan; Pérez-Martínez, Pablo; Quintana-Navarro, Gracia M.; Marı́n, Carmen; Ordovás, José M.; Ommen, Ben van; Pérez-Jiménez, Francisco; Delgado-Lista, Javier; López‐Miranda, José

doi:10.1007/s00125-015-3776-4

Cited by 78 publications

(85 citation statements)

References 38 publications

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“…There is a strongly increasing interest in this type of biomarker in nutrition and health studies, demonstrating their use in uncovering early alterations in metabolism preceeding chronic diseases [9,[11][12][13][14]. Recently, it was shown that quantification of challenge response significantly contributes to demonstrating health effects of food and nutrition in dietary intervention studies [6,7,[14][15][16][17][18]. A standardized optimal nutritional challenge test was defined after performance of a systematic literature review [3].…”

Section: Introductionmentioning

confidence: 99%

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

et al. 2017

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Background: A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultaneous quantification of major metabolic health processes. Currently, applied challenge tests are largely non-standardized. A systematic review defined an optimal nutritional challenge test, the "PhenFlex test" (PFT). This study aimed to prove that PFT modulates all relevant processes governing metabolic health thereby allowing to distinguish subjects with different metabolic health status. Therefore, 20 healthy and 20 type 2 diabetic (T2D) male subjects were challenged both by PFT and oral glucose tolerance test (OGTT). During the 8-h response time course, 132 parameters were quantified that report on 26 metabolic processes distributed over 7 organs (gut, liver, adipose, pancreas, vasculature, muscle, kidney) and systemic stress.

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Section: Introductionmentioning

confidence: 99%

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

et al. 2017

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“…Although, due to the longitudinal character of CORDIOPREV, the clinical outcomes will not be unveiled until the end of the intervention periods, several papers have been already published from baseline data from the CORDIOPREV study which have yielded useful insights about genetics, human metabolism or inflammation. 35–40 From the conceptual point of view, this study will fill the gap in long-term studies on secondary prevention using dietary approaches. Moreover, it will contribute to our understanding of the use of more personalized strategies.…”

Section: Discussionmentioning

confidence: 99%

“…As an example, recently published papers from CordioPrev dealing with genetics or postprandial lipemia used ANOVA tests for quantitative variables and Chi-square for qualitative variables 35–40 . As a general rule, all levels of significance for regular tests will be set at α=0.05, and Parametric tests will be used whenever possible.…”

Section: Methods and Designmentioning

confidence: 99%

CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (the CORDIOPREV study): Rationale, methods, and baseline characteristics

Delgado-Lista

Pérez-Martínez

García‐Rios

et al. 2016

American Heart Journal

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145

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Coronary heart disease (CHD) represents a major global health burden. However, despite the well-known influence that dietary habits exert over the progression of this disease, there are no well-established and scientifically sound dietary approaches to prevent the onset of clinical outcomes in secondary prevention. The objective of the CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (CORDIOPREV study, clinical trials number NCT00924937) is to compare the ability of a Mediterranean diet rich in virgin olive oil versus a low-fat diet to influence the composite incidence of cardiovascular events after 7 years, in subjects with documented CHD at baseline. For this purpose, we enrolled 1002 coronary patients from Spain. Baseline assessment (2009–12) included detailed interviews and measurements to assess dietary, social and biological variables. Results of baseline characteristics: The CORDIOPREV study in Spain describes a population with a high BMI (37.2% overweight and 56.3% obesity), with a median of LDL-cholesterol of 88.5 mg/dL (70.6% of the patients having <100 mg/dL, and 20.3% patients < 70 mg/dL). 9.6% of the participants were active smokers, and 64.4% were former smokers. Metabolic Syndrome was present in 58% of this population. To sum up, we describe here the rationale, methods and baseline characteristics of the CORDIOPREV study, which will test for the first time the efficacy of a Mediterranean Diet rich in extra virgin olive oil as compared with a low-fat diet on the incidence of CHD recurrence in a long term follow-up study.

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“…As regards diabetic status at baseline, 540 of the subjects were T2DM patients and 462 were nondiabetics who had not been diagnosed with T2DM in the CORDIOPREV study . Of these, 107 patients developed T2DM according to the American Diabetes Association (ADA) diagnosis criteria after a median follow‐up of 59 months.…”

Section: Methodsmentioning

confidence: 99%

Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study

Roncero-Ramos

Rangel‐Zúñiga

López-Moreno

et al. 2018

Molecular Nutrition Food Res

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The insulin resistance phenotype (muscle or liver) interacts with the type of diet to determine changes in disposition index after 2 years of intervention: the CORDIOPREV-DIAB randomised clinical trial

Cited by 78 publications

References 38 publications

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

CORonary Diet Intervention with Olive oil and cardiovascular PREVention study (the CORDIOPREV study): Rationale, methods, and baseline characteristics

Mediterranean Diet, Glucose Homeostasis, and Inflammasome Genetic Variants: The CORDIOPREV Study

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