The insulin resistant subphenotype of polycystic ovary syndrome: clinical parameters and pathogenesis

Mor, Eliran; Zograbyan, Arus; Saadat, Peyman; Bayrak, Aykut; Tourgeman, David E; Zhang, Chunying; Stanczyk, Frank Z.; Paulson, Richard J.

doi:10.1016/j.ajog.2004.02.052

Cited by 40 publications

(25 citation statements)

References 22 publications

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“…A positive correlation was shown between androgens and insulin levels in the NC-CAH group. This correlation has also been demonstrated in many studies with PCOS patients [30,31,32] with or without body mass excess. Not many studies were found in the literature investigating NC-CAH patients on this aspect.…”

Section: Discussionmentioning

confidence: 61%

Hyperinsulinemia and Insulin Insensitivity in Women with Nonclassical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: The Relationship between Serum Leptin Levels and Chronic Hyperinsulinemia

2005

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Background/Aim: Nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency (NC-CAH) is associated with hyperandrogenemia, chronic anovulation, hirsutism, acne and adrenal hyperplasia. A few studies have shown hyperinsulinemia and insulin insensitivity in NC-CAH. Hyperinsulinemia can stimulate leptin secretion, and androgens can inhibit leptin secretion. Thus, we designed a study to investigate the insulin levels and insulin sensitivity and the effect of chronic endogenous hyperinsulinemia and androgens on leptin in patients with NC-CAH. Methods: Eighteen women with untreated NC-CAH and 26 normally cycling control women with a similar body mass index (BMI) were studied. Basal hormones, fasted and fed insulin levels, leptin and stimulated 17-hydroxyprogesterone (17-OHP) concentrations were studied. Homeostasis model assessment was used to assess insulin sensitivity. Results: The basal 17-OHP, the free testosterone (fT) and dehydroepiandrosterone sulfate (DHEA-S) were significantly different in the 2 groups (p < 0.05). Fasting and fed insulin levels of the NC-CAH group were higher than those of the control group (p < 0.05) and insulin sensitivity was lower in NC-CAH than in controls (p < 0.05). Insulin levels were correlated with fT and 17-OHP (p < 0.05). Serum leptin levels for NC-CAH (25.9 ± 12.5 µg/l) did not differ from the controls (25.4 ± 12.06 µg/l) and were positively correlated with BMI (r = 0.725) and percent body fat (r = 0.710) for both groups (both p < 0.001). Leptin levels were not correlated with estrogen or androgens, gonadotropins or insulin levels. Conclusion: Hyperinsulinemia and insulin insensitivity associated with hyperandrogenism were detected in untreated NC-CAH patients as in previous reports, whereas serum leptin levels did not differ from those of controls.

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Section: Discussionmentioning

confidence: 61%

Hyperinsulinemia and Insulin Insensitivity in Women with Nonclassical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: The Relationship between Serum Leptin Levels and Chronic Hyperinsulinemia

2005

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“…Different studies have reported different prevalence rates of insulin resistance in women with PCOS. Whereas some investigators have suggested that insulin resistance is universal in these women [13], others are of the opinion that it is present in no more than 40% to 70% of cases [14,15].…”

Section: Discussionmentioning

confidence: 92%

Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome

El-Mazny

Abou-Salem

El-Sherbiny

et al. 2010

International Journal of Gynecology & Obstetrics

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“…Till date, the mechanisms of CC resistance in women with PCOS remain unclear. Elevated of testosterone [14] and IR [15] have been reported as predictive factors in CC-resistant PCOS. Ellakwa et al [16] promoted that a combination of patient amenorrhea, BMI, total testosterone, AMH, ovarian volume, ovarian stromal artery pulsatility index, and visceral fat area could be used to predict CC treatment response, but thyroid function was not referred in their study.…”

Section: Introductionmentioning

confidence: 98%

Subclinical hypothyroidism is associated with metabolic syndrome and clomiphene citrate resistance in women with polycystic ovary syndrome

Xia

et al. 2016

Gynecological Endocrinology

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The insulin resistant subphenotype of polycystic ovary syndrome: clinical parameters and pathogenesis

Cited by 40 publications

References 22 publications

Hyperinsulinemia and Insulin Insensitivity in Women with Nonclassical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: The Relationship between Serum Leptin Levels and Chronic Hyperinsulinemia

Hyperinsulinemia and Insulin Insensitivity in Women with Nonclassical Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency: The Relationship between Serum Leptin Levels and Chronic Hyperinsulinemia

Insulin resistance, dyslipidemia, and metabolic syndrome in women with polycystic ovary syndrome

Subclinical hypothyroidism is associated with metabolic syndrome and clomiphene citrate resistance in women with polycystic ovary syndrome

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