2022
DOI: 10.1371/journal.pone.0272437
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The insulin sensitivity Mcauley index (MCAi) is associated with 40-year cancer mortality in a cohort of men and women free of diabetes at baseline

Abstract: Background The association between insulin resistance and cancer-mortality is not fully explored. We investigated the association between several insulin sensitivity indices (ISIs) and cancer-mortality over 3.5 decades in a cohort of adult men and women. We hypothesized that higher insulin resistance will be associated with greater cancer-mortality risk. Methods A cohort of 1,612 men and women free of diabetes during baseline were followed since 1979 through 2016 according to level of insulin resistance (IR)… Show more

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Cited by 3 publications
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“…Loss of muscle mass can lead to insulin resistance [ 48 ], which is known to be associated with increased all-cause, cardiovascular disease [ 49 51 ] and cancer [ 51 53 ] mortality. Decreasing BMI may also be a marker of frailty, which is also known to be associated to increased mortality [ 54 ]. This is supported by the fact that we did not find an association of waist circumference with all-cause or cardiovascular mortality.…”
Section: Discussionmentioning
confidence: 99%
“…Loss of muscle mass can lead to insulin resistance [ 48 ], which is known to be associated with increased all-cause, cardiovascular disease [ 49 51 ] and cancer [ 51 53 ] mortality. Decreasing BMI may also be a marker of frailty, which is also known to be associated to increased mortality [ 54 ]. This is supported by the fact that we did not find an association of waist circumference with all-cause or cardiovascular mortality.…”
Section: Discussionmentioning
confidence: 99%