ESA's hard X-ray and soft gamma-ray observatory INTEGRAL is covering the 3 keV to 10 MeV energy band, with excellent sensitivity during long and uninterrupted observations of a large field of view (∼ 100 square degrees), with ms time resolution and keV energy resolution. It links the energy band of pointed soft X-ray missions such as XMMNewton with that of high-energy gamma-ray space missions such as Fermi and ground based TeV observatories. Key results obtained so far include the first sky map in the light of the 511 keV annihilation emission, the discovery of a new class of high mass X-ray binaries and detection of polarization in cosmic high energy radiation. For the foreseeable future, INTE-GRAL will remain the only observatory allowing the study of nucleosynthesis in our Galaxy, including the long overdue next nearby supernova, through high-resolution gamma-ray line spectroscopy. Science results to date and expected for the coming mission years span a wide range of high-energy astrophysics, including studies of the distribution of positrons in the Galaxy; reflection of gamma-rays off clouds in the interstellar medium near the Galactic Centre; studies of black holes and neutron stars particularly in high-mass systems; gamma-INTEGRAL: The International Gamma-Ray Astrophysics Laboratory, an ESA project with instruments and science data centre funded by ESA member states (especially the PI countries: 150 C. Winkler et al. ray polarization measurements for X-ray binaries and gamma-ray bursts, and sensitive detection capabilities for obscured active galaxies with more than 1000 expected to be found until 2014. This paper summarizes scientific highlights obtained since INTEGRAL's launch in 2002, and outlines prospects for the INTEGRAL mission.