The intensity dependence of the auditory evoked N1 component as a predictor of reponse to Citalopram treatment in patients with major depression

Linka, T.; Müller, Bernhard; Bender, Stefan; Sartory, Gudrun

doi:10.1016/j.neulet.2004.06.038

Cited by 60 publications

(49 citation statements)

References 20 publications

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“…Furthermore, evidence suggests that the LDAEP can serve as a predictor of responses to SSRI treatment in GAD patients, which phenomenon was previously observed in patients with MDD (Gallinat et al, 2000;Linka et al, 2004). Research has indicated that a strong LDAEP-indicating lower serotonergic activity and turnover rate-is associated with a favorable response to SSRI treatment in patients with depression (Gallinat et al, 2000;Linka et al, 2004). Our study (Park et al, 2011) also showed that GAD patients who had stronger LDAEPs responded favorably to SSRI (escitalopram) treatment.…”

Section: Loudness Of the Auditory Evoked Potentialsupporting

confidence: 77%

“…However, further studies are needed to explicate the relationship between different anxiety disorders and the strength of LDAEP. Furthermore, evidence suggests that the LDAEP can serve as a predictor of responses to SSRI treatment in GAD patients, which phenomenon was previously observed in patients with MDD (Gallinat et al, 2000;Linka et al, 2004). Research has indicated that a strong LDAEP-indicating lower serotonergic activity and turnover rate-is associated with a favorable response to SSRI treatment in patients with depression (Gallinat et al, 2000;Linka et al, 2004).…”

Section: Loudness Of the Auditory Evoked Potentialmentioning

confidence: 67%

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Psychophysiological Markers of Anxiety Disorders and Anxiety Symptoms

Lee¹,

Park²

2011

Anxiety Disorders

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Section: Loudness Of the Auditory Evoked Potentialsupporting

confidence: 77%

Section: Loudness Of the Auditory Evoked Potentialmentioning

confidence: 67%

Psychophysiological Markers of Anxiety Disorders and Anxiety Symptoms

Lee¹,

Park²

2011

Anxiety Disorders

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“…102,103 A high IDAP correlates positively with clinical symptoms of major depression 104 that are thought to be associated with decreased serotonergic signal ling, and normalizes in depressed patients treated with selective serotonin reuptake inhibitors. 105 IDAP abnor malities also correlate with personality traits thought to be associated with decreased serotonergic transmis sion in individuals with migraine. 106 Treatment with migraine preventing drugs such as β blockers, which increase serotonergic transmission, normalizes the increased interictal IDAP in patients with migraine.…”

Section: Amplitude-stimulus Intensity Functionmentioning

confidence: 95%

Altered processing of sensory stimuli in patients with migraine

et al. 2014

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| Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

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“…A diminished serotonergic neurotransmission is considered as one biological basis of depressive disorders and is the rationale for treatments with serotonergic antidepressants. Consequently, strong loudness dependence in depressive patients indicative for a weak serotonergic neurotransmission has been shown to predict a favourable response to selective serotonin reuptake inhibitors (SSRI) (Hegerl et al 2001;Linka et al 2004). Furthermore, in withdrawn alcohol-dependent patients a highly significant inverse correlation was found between the loudness dependence and the personality trait ''Harm Avoidance'' from Cloninger's Temperament and Character Inventory, which is supposed to be associated with both a low serotonergic neurotransmission and an increased risk to develop depressive disorders and alcohol dependence (Herrmann et al 2001).…”

Section: Neurophysiological Findingsmentioning

confidence: 99%

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

Mößner

Mikova

Koutsilieri

et al. 2007

The World Journal of Biological Psychiatry

227

126

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Biological markers for depression are of great interest to aid in elucidating the causes of major depression. We assess currently available biological markers to query their validity for aiding in the diagnosis of major depression. We specifically focus on neurotrophic factors, serotonergic markers, biochemical markers, immunological markers, neuroimaging, neurophysiological findings, and neuropsychological markers. We delineate the most robust biological markers of major depression. These include decreased platelet imipramine binding, decreased 5-HT1A receptor expression, increase of soluble interleukin-2 receptor and interleukin-6 in serum, decreased brain-derived neurotrophic factor in serum, hypocholesterolemia, low blood folate levels, and impaired suppression of the dexamethasone suppression test. To date, however, none of these markers are sufficiently specific to contribute to the diagnosis of major depression. Thus, with regard to new diagnostic manuals such as DSM-V and ICD-11 which are currently assessing whether biological markers may be included in diagnostic criteria, no biological markers for major depression are currently available for inclusion in the diagnostic criteria.

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The intensity dependence of the auditory evoked N1 component as a predictor of reponse to Citalopram treatment in patients with major depression

Cited by 60 publications

References 20 publications

Psychophysiological Markers of Anxiety Disorders and Anxiety Symptoms

Psychophysiological Markers of Anxiety Disorders and Anxiety Symptoms

Altered processing of sensory stimuli in patients with migraine

Consensus paper of the WFSBP Task Force on Biological Markers: Biological Markers in Depression

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