The intensity of awake bruxism episodes is increased in individuals with high trait anxiety

Rofaeel, Madonna; Chow, Jeffrey Chi-Fai; Cioffi, Iacopo

doi:10.1007/s00784-020-03650-5

Cited by 24 publications

(29 citation statements)

References 45 publications

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“…Previous studies have demonstrated a strong correlation between psychological stress and masticatory muscle disorder, which is the main reported symptom of TMD patients ( Owczarek et al, 2020 ; Yap and Natu, 2020 ; Rofaeel et al, 2021 ). Dentists are interested in determining the central mechanisms underlying this phenomenon.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies suggested that patients with TMD tend to be more anxious and/or depressed than asymptomatic control subjects ( Gameiro et al, 2006 ; Kindler et al, 2012 ; Al-Khotani et al, 2016 ; Simoen et al, 2020 ). Regarding masticatory muscle disorder, several clinical studies have confirmed that people exposed to more stress stimuli are more likely to develop a state of masticatory muscle hyperactivity or allodynia ( Owczarek et al, 2020 ; Yap and Natu, 2020 ; Rofaeel et al, 2021 ). Consistent with these findings, data from animals under experimental stress showed that the masseter muscle significantly exhibited bruxism-like activity and metabolic dysfunction ( Rosales et al, 2002 ; Song et al, 2014 ; Lin et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

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Activation of the Mesencephalic Trigeminal Nucleus Contributes to Masseter Hyperactivity Induced by Chronic Restraint Stress

Zhao

Liu

Wang³

et al. 2022

Front. Cell. Neurosci.

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Psychological stress is commonly accepted to be closely associated with masticatory muscle disorder, which is the main symptom of temporomandibular disorder (TMD). Previous studies have confirmed that exposure to stress may cause masticatory muscle hyperactivity. However, the central mechanism underlying this process remains unclear. The mesencephalic trigeminal nucleus (Vme), which resides in the brainstem, is the primary afferent center for masticatory proprioception and plays a key role in oral–motor movements by projecting to the trigeminal motor nucleus (Vmo). Therefore, the present study was designed to examine the role of Vme neurons in masseter overactivity induced by chronic stress. We found that subjecting mice to restraint stress (6 h/day) for 14 days caused significant anxiety-like behavior, obvious masseter overactivity, and markedly enhanced electrophysiological excitability of Vme neurons. By using anterograde tract tracing combined with immunofluorescence staining methods, we observed vesicular glutamate transporter 1 (VGLUT1)-positive glutamatergic projections from the Vme to the Vmo. Moreover, chronic restraint stress (CRS) elevated the expression of VGLUT1 and choline acetyltransferase (ChAT) in Vmo. Furthermore, administration of VGLUT1-targeted short hairpin RNA (shRNA) into the bilateral Vme significantly suppressed the enhanced overexcitability of Vme neurons, downregulated the overexpression of VGLUT1 and ChAT in the Vmo, and attenuated the elevated overactivity of the masseter caused by CRS. Taken together, we showed that CRS can excite neurons in the Vme, enhancing glutamatergic excitatory projections from the Vme to the Vmo and resulting in masseter muscle overactivity. These findings provide us with a novel central mechanism underlying the correlation between psychological factors and TMD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Activation of the Mesencephalic Trigeminal Nucleus Contributes to Masseter Hyperactivity Induced by Chronic Restraint Stress

Zhao

Liu

Wang³

et al. 2022

Front. Cell. Neurosci.

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“…It is well known that the amygdala mediates fear and anxiety‐like behaviors (Babaev et al, 2018). Of importance, individuals with increased trait anxiety have greater incidence and intensity of spontaneous awake bruxism, a repetitive jaw‐muscle activity characterized by clenching or grinding of the teeth occurring during wakefulness and/or by bracing or thrusting of the mandible (Lobbezoo et al, 2013; Rofaeel et al, 2021). There is evidence that awake‐bruxism plays a crucial role in the onset and maintenance of myogenic temporomandibular disorders (mTMD), which are characterized primarily by spontaneous pain or pain associated with jaw function (Schiffman et al, 2014; Slade et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An ultra‐high field diffusion MRI study

Kaya

Geha

Araújo

et al. 2022

Human Brain Mapping

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The neuroanatomical circuitry of jaw muscles has been mostly explored in non‐human animals. A recent rodent study revealed a novel circuit from the central amygdala (CeA) to the trigeminal motor nucleus (5M), which controls biting attacks. This circuit has yet to be delineated in humans. Ultra‐high diffusion‐weighted imaging data from the Human Connectome Project (HCP) allow in vivo delineation of circuits identified in other species—for example, the CeA–5M pathway—in humans. We hypothesized that the CeA–5M circuit could be resolved in humans at both 7 and 3 T. We performed probabilistic tractography between the CeA and 5M in 30 healthy young adults from the HCP database. As a negative control, we performed tractography between the basolateral amygdala (BLAT) and 5M, as CeA is the only amygdalar nucleus with extensive projections to the brainstem. Connectivity strength was operationalized as the number of streamlines between each region of interest. Connectivity strength between CeA–5M and BLAT–5M within each hemisphere was compared, and CeA–5M circuit had significantly stronger connectivity than the BLAT–5M circuit, bilaterally at both 7 T (all p < .001) and 3 T (all p < .001). This study is the first to delineate the CeA–5M circuit in humans.

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“…Bruxism is currently considered as a behavior and not as a parafunction or disorder in otherwise healthy individuals. It is a very complex phenomenon of central origin [ 2 , 3 ] that can affect the sleep structure [ 4 ], and can occur alone or with comorbidities such as obstructive sleep apnea (OSA), gastroesophageal reflux disease, insomnia, headache, orofacial pain, periodic limb movement, rapid eye movement behavior disorder, sleep epilepsy, anxiety disorders and depression [ 5 , 6 , 7 ].…”

mentioning

confidence: 99%

Temporomandibular Disorders Related Pain among Sleep & Awake Bruxers: A Comparison among Sexes and Age

Winocur

Więckiewicz

2023

JCM

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The intensity of awake bruxism episodes is increased in individuals with high trait anxiety

Cited by 24 publications

References 45 publications

Activation of the Mesencephalic Trigeminal Nucleus Contributes to Masseter Hyperactivity Induced by Chronic Restraint Stress

Activation of the Mesencephalic Trigeminal Nucleus Contributes to Masseter Hyperactivity Induced by Chronic Restraint Stress

Identification of central amygdala and trigeminal motor nucleus connectivity in humans: An ultra‐high field diffusion MRI study

Temporomandibular Disorders Related Pain among Sleep & Awake Bruxers: A Comparison among Sexes and Age

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