The Interaction between a Drug and Ultrasound in Sonochemotherapy against Ovarian Cancers

He, Hongkun; Yu, Tinghe; Zhang, Y.

doi:10.1055/s-0029-1245876

Cited by 18 publications

(16 citation statements)

References 16 publications

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“…This manner indicated that both the drug peak level and "concentration £ time" were with the range of human pharmacokinetics, thereby having clinical relevancy. 16,17 Combination of PDT and DDP Experiments were performed in 4 groups. Cells were exposed to DDP in group DDP, to PDT in group PDT, and to PDT combined with DDP in group PDT C DDP; control cells received sham exposure (i.e., with 0 mM drug and 0 J/cm 2 light).…”

Section: Cytotoxicity Of Mppa Light or Ddpmentioning

confidence: 99%

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Deactivation of cisplatin-resistant human lung/ovary cancer cells with pyropheophorbide-α methyl ester-photodynamic therapy

Qian

Wang

Zheng

et al. 2017

Cancer Biology & Therapy

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The aim of this study was to determine whether photodynamic therapy (PDT) alone or combined with cisplatin (DDP), can deactivate cisplatin-resistant cancer cells. Human cancer cell lines A549 and SKOV3, and chemoresistant sublines A549/DDP and SKOV3/DDP, were subjected to PDT, DDP, or PDT combined with DDP. Cell viability and apoptosis were analyzed, and then intracellular reactive oxygen species (ROS) and proteins related to apoptosis were determined. PDT caused cell death, and PDT combined with DDP led to the highest percentage of dead cells in 4 cell lines; similar results were detected in ROS; a quantification evaluation manifested that the combined effect was addition. DDP increased the percentage of apoptotic cells, and the ROS level in A549 and SKOV3 cells, which was not observed in A549/DDP and SKOV3/DDP cells. Western blot revealed an increase of caspase 3 and Bax, and a decrease of Bcl-2, demonstrating the occurrence of apoptosis. The data suggest that PDT can efficiently deactivate resistant cells and enhance the action of DDP against resistant cancer cells.

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Section: Cytotoxicity Of Mppa Light or Ddpmentioning

confidence: 99%

“…Quantifying the combined effect of PDT and DDP Percentages of dead (1percentage of survival cells) or apoptotic cells were used to (CI), thereby evaluating the combined effect. 16 CI D…”

Section: Detection Of Apoptotic Cellsmentioning

confidence: 99%

Deactivation of cisplatin-resistant human lung/ovary cancer cells with pyropheophorbide-α methyl ester-photodynamic therapy

Qian

Wang

Zheng

et al. 2017

Cancer Biology & Therapy

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“…HIFU directly ablated tissues, but drugs and radiation deactivated cells via a series of intracellular processes. Cancer type and drug were the determents of the interaction, and HIFU cavitation can decrease the potency of a drug [24, 25]. Thus, only a specific regimen can be introduced during HIFU for a specific case.…”

Section: Resultsmentioning

confidence: 99%

Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound: Implications from the Present Clinical Trials

2014

The Scientific World Journal

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Extracorporeal ultrasound-guided high intensity focused ultrasound (HIFU) has been clinically used for 15 years, and over 36000 cases have been reported. However, there yet lacked a consensus in the clinical values, suggesting the necessity of checking clinical findings. Clinical trials were searched and data reevaluated. HIFU was hardly performed alone; almost all present anticancer means have been applied during an HIFU treatment, and a specific regimen varied between trials; there were heterogeneity and disagreement between trials. The complexity made it difficult to distinguish the effect of HIFU. Based upon evaluable data, the efficacy of HIFU was similar to that of radio frequency, chemoembolization, chemotherapy, radiotherapy, or hormone therapy; a combined therapy did not improve the efficacy. The survival rate of HIFU plus radiotherapy was lower than that of radical surgery in liver cancers. Adverse events had no downtrend in the past years. HIFU was not a standardized procedure where the intensity and insonation mode were modified constantly throughout a treatment, limiting an evaluation from the perspective of ultrasonics. These implied that HIFU should be applied as an alternative at most occasions. The present clinical trials had defects making against the understating of HIFU.

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“…OVCAR-3 cells were chosen as they are Doxsensitive and represent a good cancer model for localized hyperthermia. [39,40] The mitochondrial activity results showed that unloaded nanoparticles were not toxic up to 500 µg.mL -1 , whereas 60 % of mitochondrial activity was retained at 1 mg.mL -1 (Fig. 7a).…”

Section: Cell Culturementioning

confidence: 98%

The crucial role of macromolecular engineering, drug encapsulation and dilution on the thermoresponsiveness of UCST diblock copolymer nanoparticles used for hyperthermia

Bordat

Soliman

Chraït

et al. 2019

European Journal of Pharmaceutics and Biopharmaceutics

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Poly(acrylamide-co-acrylonitrile) (P(AAm-co-AN)), an upper critical solution temperature (UCST)type copolymer in water, was synthesized by reversible addition fragmentation chain transfer (RAFT) copolymerization and used as a macro-RAFT agent for the polymerization of oligo(ethylene glycol) methyl ether methacrylate (OEGMA) to yield amphiphilic diblock P(AAm-co-AN)-b-POEGMA copolymer. A series of copolymers with different AN content was obtained allowing to finely tune the UCST behavior (cloud point (Tt-UCST) from 35 to 78°C). Addition of the POEGMA block did not modify the Tt-UCST regardless its Mn but provided a lower critical solution temperature behavior at high temperature. Nanoparticles were then formulated by the nanoprecipitation technique revealing that copolymers with higher Tt-UCST yield smaller, better-defined nanoparticles. Eventually, doxorubicin (Dox) was encapsulated into nanoparticles made from the copolymer having a Tt-UCST close to mild hyperthermia (~43°C). Surprisingly, Dox encapsulation increased Tt-UCST and gave smaller nanoparticles as opposed to their unloaded counterparts. The dilution of the suspension also led to a decrease of Tt-UCST. No obvious hyperthermia effect was observed on the cytotoxicity of Dox-loaded nanoparticles. Our study highlighted the influence of macromolecular engineering, drug encapsulation and nanoparticle dilution on UCST behavior, important features often overlooked despite their crucial impact in the development of thermosensitive nanoscale drug delivery systems.

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The Interaction between a Drug and Ultrasound in Sonochemotherapy against Ovarian Cancers

Cited by 18 publications

References 16 publications

Deactivation of cisplatin-resistant human lung/ovary cancer cells with pyropheophorbide-α methyl ester-photodynamic therapy

Deactivation of cisplatin-resistant human lung/ovary cancer cells with pyropheophorbide-α methyl ester-photodynamic therapy

Extracorporeal Ultrasound-Guided High Intensity Focused Ultrasound: Implications from the Present Clinical Trials

The crucial role of macromolecular engineering, drug encapsulation and dilution on the thermoresponsiveness of UCST diblock copolymer nanoparticles used for hyperthermia

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