The interaction between MALAT1 and TUG1 with dietary fatty acid quality indices on visceral adiposity index and body adiposity index

Abstract

We aimed to investigate the interaction between the transcript levels of taurine-upregulated gene 1 (TUG1) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the Cholesterol-Saturated Fat Index (CSI) in relation to the visceral adiposity index (VAI) and body adiposity index (BAI). This cross-sectional study involved 346 women classified as obese and overweight, aged between 18 and 48 years. Dietary intake and the quality of dietary fat were assessed using a validated and reliable 147-item semi-quantitative food frequency questionnaire, with the Cholesterol-Saturated Fat Index (CSI) used as an indicator. Transcription levels of MALAT1 and TUG1 were evaluated through real-time polymerase chain reaction following the criteria outlined in the Minimum Information for Publication of Quantitative standards. Serum profiles were measured using standard protocols. We observed a positive association between transcription level of MALAT1 and VAI in both crude (β = 3.646, 95% CI 1.950–5.341, p < 0.001) and adjusted (β = 8.338, 95% CI 6.110–10.566, p < 0.001) models. Furthermore, after adjusting for confounders, a significant positive interaction was noted between MALAT1 expression and CSI on BAI (β: 0.130, 95% CI 0.019, 0.240, p = 0.022), with a marginal positive interaction observed on VAI (β: 0.718, 95% CI − 0.028, 1.463, p = 0.059). It seems that there may be a positive interaction between MALAT1 transcription level and CSI on VAI and BAI among overweight and obese women. However, no associations were seen between TUG1 mRNA level and the above-mentioned outcomes. Further functional studies are still required to elucidate this concept.

MALAT1: A Long Non-Coding RNA with Multiple Functions and Its Role in Processes Associated with Fat Deposition

“…However, the transcription levels of MALAT1 and TUG1 showed a positive correlation with major lipogenic and adipogenic genes [121], and thus the authors suggested possible roles of MALAT1 and TUG1 in obesity. Moreover, Rasaei et al [122] suggested that there may be a positive interaction effect between MALAT1 transcription levels and the cholesterol/saturated fat index, which impacts the visceral adiposity index and body adiposity index among overweight and obese women. However, it was found that MALAT1 expression was significantly reduced in atherosclerotic plaques.…”

Investigation of the interaction between genetic risk score (GRS) and fatty acid quality indices on metabolic syndrome among overweight and obese women

“…As a multifactorial disease, environmental conditions such as dietary intake and genetic variations are involved in its pathogenesis [ 10 – 15 ]. Apart from a positive connection between total fat intake and risk of MetS, as reported in a Japanese-Brazilian population, it is crucial to mention that dietary fat quality is also of utmost importance [ 16 ].…”