The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders

Ghafouri‐Fard, Soudeh; Abak, Afete; Fattahi, Faranak; Hussen, Bashdar Mahmud; Bahroudi, Zahra; Shoorei, Hamed; Taheri, Mohammad

doi:10.1016/j.biopha.2021.111519

Cited by 29 publications

(18 citation statements)

References 98 publications

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“…They are heterogeneous molecules that perform various functions via interacting with DNA, RNA, proteins, peptides, small weight molecules, miRNAs and mRNAs (Figure 1). For instance, they regulate chromatin state and cell cycle, control mRNA stability, silence retrotransposons and competitively sponge miRNAs 41–44 . These regulatory RNAs play leading roles in the modulation of gene expression at epigenetic, transcriptional and post‐transcriptional levels, thereby contributing to a variety of cellular phenomena such as RNA processing, chromatin modification, apoptosis and invasion 45 .…”

Section: Introductionmentioning

confidence: 99%

“…For instance, they regulate chromatin state and cell cycle, control mRNA stability, silence retrotransposons and competitively sponge miRNAs. 41 , 42 , 43 , 44 These regulatory RNAs play leading roles in the modulation of gene expression at epigenetic, transcriptional and post‐transcriptional levels, thereby contributing to a variety of cellular phenomena such as RNA processing, chromatin modification, apoptosis and invasion. 45 Furthermore, some lncRNAs have been indicated to be abnormally expressed in human diseases, providing support for their involvement in pathogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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Hepatocellular carcinoma (HCC), as the most prevalent liver malignancy, is annually diagnosed in more than half a million people worldwide. HCC is strongly associated with hepatitis B and C viral infections as well as alcohol abuse. Obesity and nonalcoholic fatty liver disease (NAFLD) also significantly enhance the risk of liver cancer. Despite recent improvements in therapeutic approaches, patients diagnosed in advanced stages show poor prognosis. Accumulating evidence provides support for the regulatory role of non‐coding RNAs (ncRNAs) in cancer. There are a variety of reports indicating the regulatory role of microRNAs (miRNAs) in different stages of HCC. Long non‐coding RNAs (LncRNAs) exert their effects by sponging miRNAs and controlling the expression of miRNA‐targeted genes. Circular RNAs (circRNAs) perform their biological functions by acting as transcriptional regulators, miRNA sponges and protein templates. Diverse studies have illustrated that dysregulation of competing endogenous RNA networks (ceRNETs) is remarkably correlated with HCC‐causing diseases such as chronic viral infections, nonalcoholic steatohepatitis and liver fibrosis/cirrhosis. The aim of the current article was to provide an overview of the role and molecular mechanisms underlying the function of ceRNETs that modulate the characteristics of HCC such as uncontrolled cell proliferation, resistance to cell death, metabolic reprogramming, immune escape, angiogenesis and metastasis. The current knowledge highlights the potential of these regulatory RNA molecules as novel diagnostic biomarkers and therapeutic targets in HCC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Moghadam

Bakhshinejad

Khalafizadeh

et al. 2021

J Cellular Molecular Medi

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“…The expression of both NF-κB1 (p105) and NF-κB subunit RELA (p65) are directly repressed by miR26b and miR562, and this is linked with angiogenesis in breast cancer patients ( Anbalagan et al, 2014 ). Many pathways, including the PI3K/AKT pathway, are associated with NF-κB signaling ( Ghafouri-Fard et al, 2021a ; Hussen et al, 2021b ). In addition, the phosphatidyl inositol 3-kinase/Akt signaling is involved in the production of HIF-1 and VEGF, and it is essential for the development of blood vessels in the BC ( Karar and Maity, 2011 ; Li et al, 2015 ).…”

Section: Key Micrornas In Breast Cancer Angiogenesismentioning

confidence: 99%

“…They regulate gene expression in health and disease cells by binding to the 3′-untranslated region (UTR) or other regions such as the 5′ UTR, gene promoters, and the coding sequence ( Broughton et al, 2016 ). Also, it has been established that crosstalk exists between long non-coding RNAs and miRNAs, where these two networks interact and form complex networks in gene regulation pathways ( Ghafouri-Fard et al, 2021a ; Ghafouri-Fard et al, 2021b ; Dastmalchi et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

Hussen

Abdullah

Rasul

et al. 2021

Front. Mol. Biosci.

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The high incidence of breast cancer (BC) is linked to metastasis, facilitated by tumor angiogenesis. MicroRNAs (miRNAs or miRs) are small non-coding RNA molecules that have an essential role in gene expression and are significantly linked to the tumor development and angiogenesis process in different types of cancer, including BC. There’s increasing evidence showed that various miRNAs play a significant role in disease processes; specifically, they are observed and over-expressed in a wide range of diseases linked to the angiogenesis process. However, more studies are required to reach the best findings and identify the link among miRNA expression, angiogenic pathways, and immune response-related genes to find new therapeutic targets. Here, we summarized the recent updates on miRNA signatures and their cellular targets in the development of breast tumor angiogenetic and discussed the strategies associated with miRNA-based therapeutic targets as anti-angiogenic response.

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“…Thus, identification the regulatory mechanisms for modulation of NF-κB signaling in PD is an important issue for implementation of appropriate treatments for this disorder. Recent studies have revealed interactions between this signaling pathway and several of non-coding RNAs ( 6 ). These transcripts, particularly long non-coding RNAs (lncRNAs) have been suggested to participate in the pathophysiology of neuropsychiatric disorders, such as schizophrenia ( 7 ).…”

Section: Introductionmentioning

confidence: 99%

Expression Analysis of NF-κB-Related lncRNAs in Parkinson’s Disease

et al. 2021

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Parkinson’s disease (PD) has been shown to affect approximately 1% of the persons aged more than 65 years. This multifactorial disorder has been associated with abnormal function of NF-κB signals. In this research, we have evaluated expressions of NF-κB-related long non-coding RNAs in the circulation of PD patients compared with healthy controls. Expression of PACER was lower in total PD patients compared with healthy persons (Ratio of mean expressions (RME)=0.32, P value<0.001). This pattern was also evident among males (RME=0.25, P value<0.001). Expression of DILC was higher in total PD patients (RME=4.07, P value<0.001), and in both sex-based subgroups (RME=3.77, P value=0.01 and RME=4.25, P value<0.001, for females and males, respectively). Similarly, CEBPA was significantly over-expressed in total PD patients (RME=14.76, P value<0.001), and in both sex-based subgroups (RME=12.42, P value<0.001 and RME=15.80, P value<0.001, for females and males, respectively). ATG5 had a similar expression pattern (RME=2.6, P value=1E-08, RME=1.73, P value=0.03 and RME=3.09, P value=1E-07, for total cases, females and males, respectively). H19 was up-regulated in total cases and male cases compared with corresponding controls (RME=2.19, P value<0.001, RME=2.68, P value=0.01, respectively). Finally, HNFA1-AS was down-regulated in all comparisons (RME=0.10, P value=2E-06, RME=0.08, P value<0.001 and RME=0.12, P value<0.001, for total cases, females and males, respectively). Among PD patients, expressions of NKILA and ADINR were robustly correlated with each other (r=0.75, P value=2.40E-10). In addition, expression levels of DICER1-AS were significantly correlated with those of ADINR, PACER and H19 in these patients (r=0.73, P value=1.76E-9; r=0.72, P value=5.15E-09 and r=0.72, P value=3.09E-09, respectively). Correlation analyses among healthy controls revealed robust correlations between CHAST and CEBPA (r=0.84, P value=3.09E-09), NKILA and ADINR (r=0.80, P value=4.24E-12) as well as between DILC and CHAST (r=0.76, P value=1.70E-10). CEBPA had the best parameters among all assessed genes (AUC=0.96, Sensitivity=0.90 and specificity=0.97). DILC and ATG5 were the most appropriate markers after CEBPA with AUC values of 0.82 and 0.80, respectively. Most notably, combination of all genes improved AUC, sensitivity and specificity parameters to 1, 0.97 and 0.99, respectively. Cumulatively, the current study provides evidence for participation of NF-κB-related lncRNAs in the pathoetiology of PD.

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The interaction between miRNAs/lncRNAs and nuclear factor-κB (NF-κB) in human disorders

Cited by 29 publications

References 98 publications

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

Non‐coding RNA‐associated competitive endogenous RNA regulatory networks: Novel diagnostic and therapeutic opportunities for hepatocellular carcinoma

MicroRNAs: Important Players in Breast Cancer Angiogenesis and Therapeutic Targets

Expression Analysis of NF-κB-Related lncRNAs in Parkinson’s Disease

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