The interaction between neurokinin-1 receptors and cyclooxygenase-2 in fever genesis

The NK-1 Receptor Signaling: Distribution and Functional Relevance in the Eye

“…Specifically, the truncated form lacks 96 amino acids in its C-terminal site, due to the presence of a premature stop codon before exon-5. The two types of NK1R are also different in term of SP affinity, the full-length form being ten times more affine to SP, despite the fact that the SP binding domain is similar in both isoforms [7,11,13]. In fact, nanomolar concentrations of SP are sufficient to activate the full length NK1R, whereas micromolar concentrations of SP are required to activate truncated-NK1R [13].…”

“…The NK1R is widely expressed in the eye, including ocular (corneal and retinal cells) and non-ocular cells (endothelial cells, leukocytes, and neurons) [3,7].…”