The interaction between stearic acid monolayers and butane under elevated pressures

Giebel, F. J.; Paulus, Michael; Nase, Julia; Kiesel, Irena; Bieder, Steffen; Tolan, Metin

doi:10.1016/j.colsurfa.2016.05.067

Cited by 2 publications

(2 citation statements)

References 26 publications

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“…X-ray diffraction studies have revealed that non-surface active molecules such as alkanes partition in between the hydrocarbon tail groups in a monolayer and change its packing and thermodynamic properties. [45][46][47][48][49] Compression isotherm experiments by Thoma and M€ ohwald revealed that higher amounts of alkanes partition among the lipid tail groups when the length of hydrocarbon chains is comparable to that of lipid tails. 50 Therefore, we suspect that self-assembled monolayers of DOPC and POPC possess packing defects that favor the partitioning of alkane molecules between the tail groups, as shown in Figs.…”

Section: Discussionmentioning

confidence: 99%

Evaporation-induced monolayer compression improves droplet interface bilayer formation using unsaturated lipids

et al. 2018

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In this article, we report on a new experimental methodology to enable reliable formation of droplet interface bilayer (DIB) model membranes with two types of unsaturated lipids that have proven difficult for creating stable DIBs. Through the implementation of a simple evaporation technique to condition the spontaneously assembled lipid monolayer around each droplet, we increased the success rates of DIB formation for two distinct unsaturated lipids, namely 1,2-dioleoyl--glycero-3-phosphocholine (DOPC) and 1-palmitoyl-2-oleoyl--glycero-3-phosphocholine (POPC), from less than 10% to near 100%. Separately, using a pendant drop tensiometer, we learned that: (a) DOPC and POPC monolayers do not spontaneously assemble into their tightest possible configurations at an oil-water interface, and (b) reducing the surface area of a water droplet coated with a partially packed monolayer leads to a more tightly packed monolayer with an interfacial tension lower than that achieved by spontaneous assembly alone. We also estimated from Langmuir compression isotherms obtained for both lipids that the brief droplet evaporation procedure prior to DIB formation resulted in a 6%-16% reduction in area per lipid for DOPC and POPC, respectively. Finally, the increased success rates of formation for DOPC and POPC DIBs enabled quantitative characterization of unsaturated lipid membrane properties including electrical resistance, rupture potential, and specific capacitance.

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Section: Discussionmentioning

confidence: 99%

Evaporation-induced monolayer compression improves droplet interface bilayer formation using unsaturated lipids

et al. 2018

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“…To monitor the surface pressure, a microbalance was used (R&K, Potsdam, Germany). The sample plate was mounted in a gas pressure cell. , After an evaporation time of several minutes, the cell was closed, and reference measurements of the Langmuir films were taken. Thereupon, the gas pressure cell was flushed with gas.…”

Section: Methodsmentioning

confidence: 99%

Nondestructive Compression and Fluidization of Phospholipid Monolayers by Gaseous and Aerolized Perfluorocarbons: Promising Substances for Lung Surfactant Treatment

et al. 2022

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We present a surface-sensitive X-ray scattering study on the influence of gaseous and aerolized perfluorocarbons (FCs) on zwitterionic and anionic phospholipid Langmuir films, which serve as a simplified model system of lung surfactants. It was found that small gaseous FC molecules like F-propane and F-butane penetrate phospholipid monolayers and accumulate between the alkyl chains and form islands. This clustering process can trigger the formation of lipid crystallites at low initial surface pressures. In contrast, the large linear FC F-octyl bromide fluidizes membranes, causing a dissolution of crystalline domains. The bicyclic FC F-decalin accumulates between the alkyl chains of 1,2-dipalmitoyl phosphatidylcholine but cannot penetrate the more densely packed 1,2-dipalmitoyl phosphatidic acid films because of its size. The effects of FCs on lung surfactants are discussed in the framework of currently proposed therapeutic methods for acute respiratory distress syndrome using FC gases, vapor, or aerosol ventilation causing monolayer fluidization effects. This study implies that the highly biocompatible and nontoxic FCs could be beneficial in the treatment of lung diseases with injured nonfunctional lung surfactants in a novel approach for ventilation.

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The interaction between stearic acid monolayers and butane under elevated pressures

Cited by 2 publications

References 26 publications

Evaporation-induced monolayer compression improves droplet interface bilayer formation using unsaturated lipids

Evaporation-induced monolayer compression improves droplet interface bilayer formation using unsaturated lipids

Nondestructive Compression and Fluidization of Phospholipid Monolayers by Gaseous and Aerolized Perfluorocarbons: Promising Substances for Lung Surfactant Treatment

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