The interaction effect of metals exposure and dietary habit on cognitive function in Chinese older adult cohort

Liu, Peiyi; Wang, Jiahui; Mei, Pengcheng; Li, Junyu; Xu, Benhong; Ren, Xiaohu; Chen, Xiao; Wu, Desheng; Zhu, Feiqi; Yang, Xifei; He, Meian; Liu, Jianjun; Huang, Haiyan

doi:10.1016/j.jnha.2024.100284

The Journal of nutrition, health and aging

2024

DOI: 10.1016/j.jnha.2024.100284

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The interaction effect of metals exposure and dietary habit on cognitive function in Chinese older adult cohort

Peiyi Liu,

Jiahui Wang,

Pengcheng Mei

et al.

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2024

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Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

Gorini,

Tonacci

2024

Antioxidants

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Frontotemporal dementia (FTD) includes a number of neurodegenerative diseases, often with early onset (before 65 years old), characterized by progressive, irreversible deficits in behavioral, linguistic, and executive functions, which are often difficult to diagnose due to their similar phenotypic characteristics to other dementias and psychiatric disorders. The genetic contribution is of utmost importance, although environmental risk factors also play a role in its pathophysiology. In fact, some metals are known to produce free radicals, which, accumulating in the brain over time, can induce oxidative stress, inflammation, and protein misfolding, all of these being key features of FTD and similar conditions. Therefore, the present review aims to summarize the current evidence about the environmental contribution to FTD―mainly dealing with toxic metal exposure―since the identification of such potential environmental risk factors can lead to its early diagnosis and the promotion of policies and interventions. This would allow us, by reducing exposure to these pollutants, to potentially affect society at large in a positive manner, decreasing the burden of FTD and similar conditions on affected individuals and society overall. Future perspectives, including the application of Artificial Intelligence principles to the field, with related evidence found so far, are also introduced.

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Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

Gorini,

Tonacci

2024

Antioxidants

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The interaction effect of metals exposure and dietary habit on cognitive function in Chinese older adult cohort

Cited by 1 publication

References 50 publications

Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

Metal Toxicity and Dementia Including Frontotemporal Dementia: Current State of Knowledge

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