The Interaction Effect of Perioperative Cotreatment with Dextromethorphan and Intravenous Lidocaine on Pain Relief and Recovery of Bowel Function After Laparoscopic Cholecystectomy

Wu, Ching-Tang; Borel, Cecil O.; Lee, Meei-Shyuan; Yu, Jyh‐Cherng; Liou, Hang-Seng; Yi, Haun-De; Yang, Ching‐Wen

doi:10.1213/01.ane.0000142551.92340.cc

Cited by 69 publications

(81 citation statements)

References 26 publications

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“…Sevoflurane requirement was significantly reduced during abdominal surgery as monitored by BIS at all intraoperative time points [11]. The same result was found in different types of surgeries using sevoflurane [7,11,32,34] and desflurane [6,22,27]. Similarly, systemic lidocaine allowed Altermatt et al to reduce propofol requirement during the maintenance of total intravenous anesthesia for laparoscopic cholecystectomy as measured by BIS.…”

Section: Discussionmentioning

confidence: 71%

“…This may underlie the analgesia and supplementation of general anesthesia produced by systemic lidocaine infusion [26]. IV lidocaine also depresses spike activity, amplitude and conduction time in both myelinated A and unmyelinated C fibres [5,27]. Lidocaine anti-inflammatory activity may be another potential mechanism in improving perioperative pain by reducing cytokines release and neutrophil activation [8].…”

Section: Discussionmentioning

confidence: 99%

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Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

Nakhli

Kahloul

Guizani

et al. 2018

Libyan Journal of Medicine

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The role of intraoperative intravenous lidocaine infusion has been previously evaluated for pain relief, inflammatory response, and post-operative recovery, particularly in abdominal surgery. The present study is a randomized double-blinded trial in which we evaluated whether IV lidocaine infusion reduces isoflurane requirement, intraoperative remifentanil consumption and time to post-operative recovery in non-laparoscopic renal surgery. Sixty patients scheduled to undergo elective non-laparoscopic renal surgery under general anesthesia were enrolled to receive either systemic lidocaine infusion (group L: bolus 1.5 mg/kg followed by a continuous infusion at the rate of 2 mg/kg/hr until skin closure) or normal saline (0.9% NaCl solution) (Group C). The depth of anesthesia was monitored using the Bispectral Index Scale (BIS), which is based on measurement of the patient’s cerebral electrical activity. Primary outcome of the study was End-tidal of isoflurane concentration (Et-Iso) at BIS values of 40–60. Secondary outcomes include remifentanil consumption during the operation and time to extubation. Et-Iso was significantly lower in group L than in group C (0.63% ± 0.10% vs 0.92% ± 0.11%, p < 10–3). Mean remifentanil consumption of was significantly lower in group L than in group C (0.13 ± 0.04 µg/kg/min vs 0.18 ± 0.04 µg/kg/min, p < 10–3). Thus, IV lidocaine infusion permits a reduction of 31% in isoflurane concentration requirement and 27% in the intraoperative remifentanil need. In addition, recovery from anesthesia and extubation time was shorter in group L (5.8 ± 1.8 min vs 7.9 ± 2.0 min, p < 10–3). By reducing significantly isoflurane and remifentanil requirements during renal surgery, intravenous lidocaine could provide effective strategy to limit volatile agent and intraoperative opioids consumption especially in low and middle income countries.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

Nakhli

Kahloul

Guizani

et al. 2018

Libyan Journal of Medicine

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“…Lidocaine group reported less pain during movement and less postoperative morphine requirement (P < 0.05). Also, Wu CT et al detected a significant higher analgesic effect of IV lidocaine compared to control group in patients undergoing laparoscopic cholecystectomy with significant lower VAS and total meperidine consumption [28].…”

Section: Discussionmentioning

confidence: 97%

A Comparative Study of Effect of Intravenous Lidocaine Infusion, Gabapentin and Their Combination on Postoperative Analgesia after Thyroid Surgery

Shal¹

2017

OJAnes

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“…Postoperative pain is the most common cause of delay in discharge and even premature admission among patients undergoing laparoscopic surgery, which is often performed as an outpatient procedure (9,10). Pain after laparoscopy is multifactorial, and appears as a result of various reasons.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

Moslemi

Rasooli

Dehdilani

et al. 2017

Iran Red Crescent Med J

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Background: Pain after laparoscopy may still be moderate to severe due to stretching of intraabdominal cavity and peritoneal inflammation. Systemic lidocaine with anti-inflammatory properties may reduce this pain. Objectives: The aim of this study was to evaluate the effect of perioperative intravenous infusion of lidocaine on postoperative pain relief after gynecologic laparoscopic procedure. Methods: A double-blind randomized clinical trial study was conducted in Iran, during years 2014 and 2015. A sample of 60 females with American anesthesiology association (ASA) physical class I or II, who were scheduled for gynecologic laparoscopy were selected through consecutive sampling and were randomly assigned to receive either intravenous lidocaine or normal saline, as placebo, prior to induction of anesthesia and until the end of surgery. Severity of postoperative pain was evaluated starting at the recovery unit until 24 hours postoperatively for a total of 8 times using the visual analogue scale (VAS) scoring system. Time to first analgesic request, total analgesic dose used in the first 24 hours, and any probable postoperative complications were recorded. Risk ratio (RR) and number needed to treat (NNT) were used to analyze the data along with generalized linear model for multivariate analysis of repeated measurements over time. Results: The VAS at recovery was lower at recovery with a mean score of 2.8 in the lidocaine group versus 3.9 in the control group (P = 0.02). Results of generalized linear modelling revealed that pain intensity decreased over time in both groups (P = 0.02), and the groups had different trend slopes in pain intensity over repeated measurements at various time points up to 24 hours after laparoscopy, while controlling for the baseline VAS at recovery and ASA PS (P = 0.016). However, when controlling for use of painkillers, the trends were not found to be different. Patients in the lidocaine group were 3.8 times more likely not to need postoperative analgesic (95% CI: 1.4 to 9.9). Mean total analgesic dose was 1.3 mg in the lidocaine group versus 38.2 mg in the control group differing significantly between the 2 groups (P < 0.01). Use of lidocaine was associated with lower postoperative nausea and agitation. Conclusions: Systemic perioperative lidocaine could improve the pain pattern and severity as well as nausea and agitation after gynecologic laparoscopy. Although no major side effects were detected in this study, the benefits of the intervention should be weighed against its safety.

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The Interaction Effect of Perioperative Cotreatment with Dextromethorphan and Intravenous Lidocaine on Pain Relief and Recovery of Bowel Function After Laparoscopic Cholecystectomy

Cited by 69 publications

References 26 publications

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

Intravenous lidocaine as adjuvant to general anesthesia in renal surgery

A Comparative Study of Effect of Intravenous Lidocaine Infusion, Gabapentin and Their Combination on Postoperative Analgesia after Thyroid Surgery

The Effect of Intravenous Infusion of Lidocaine to Control Postoperative Pain After Gynecologic Laparoscopic Surgery: A Randomized Double-Blind Placebo-Controlled Clinical Trial

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