1999
DOI: 10.1016/s0306-3623(99)00022-1
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The interaction of 6-mercaptopurine (6-MP) and methotrexate (MTX)

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Cited by 34 publications
(35 citation statements)
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“…In the 141 available samples, total MTX-PG concentrations ranged from 0.30 to 76.3 pmol/10 9 cells (median 27 pmol/10 9 cells) and long-chain polyglutamate concentrations (MTX-PG [5][6][7] : sum of PG5 + PG6 + PG7 polyglutamate concentrations) from 0 to 16.3 pmol/10 9 cells (median 2.2 pmol/10 9 cells).…”
Section: Resultsmentioning
confidence: 99%
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“…In the 141 available samples, total MTX-PG concentrations ranged from 0.30 to 76.3 pmol/10 9 cells (median 27 pmol/10 9 cells) and long-chain polyglutamate concentrations (MTX-PG [5][6][7] : sum of PG5 + PG6 + PG7 polyglutamate concentrations) from 0 to 16.3 pmol/10 9 cells (median 2.2 pmol/10 9 cells).…”
Section: Resultsmentioning
confidence: 99%
“…11 Among the 87 patients, only 12 had more than two measurements of RBC TGNs and MTX-PG during continuation therapy (median of three determinations per patient, range 3-5). Among these 12 patients, the intrapatient coefficient of variation ranged from 2 to 65% (median 18%) for TGNs, from 19% to 92% (median 44%) for total MTXPGs, and from 13% to 117% for MTXPG [5][6][7] concentrations (median 42%).…”
Section: Resultsmentioning
confidence: 99%
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“…30,31 In recent years both in vitro and in vivo studies have supported that the interaction between 6MP and MTX is of clinical significance. 2,15,20,32,33 However, this is the first study which, in detail, explores the influence of 6MP dose and pharmacokinetics on the myelotoxicity of HDM.…”
Section: Discussionmentioning
confidence: 99%
“…3 In addition, several studies of cytotoxicity have indicated that MTX and 6MP act synergistically. [4][5][6][7][8] In hemopoietic cells, 6MP is anabolized to 6-thioguanine nucleotides (6TGNs), which are the most important mediators of the cytotoxic effect of 6MP through incorporation into DNA. 9 Erythrocytic accumulation of 6TGN correlate with the degree of myelotoxicity and remission duration in childhood ALL.…”
Section: Introductionmentioning
confidence: 99%