The Interaction of DNA with Phenanthroline and New Phenanthrocyanine Complexes of Zn(II)

Akulenkova, E. V.; Demidov, V. N.; Martynova, A. O.; Пастон, С. В.

doi:10.1134/s0006350921010048

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…For Zn(II) PC complexes, it may include their intercalation into DNA. The data obtained by us indicate that the more structurally complex, volumetric Zn(II) PC most likely form ionic associates with DNA [53] and are also capable of external binding with the forma-tion of π-stacking structures by the type of external "layering", as it is established for electronrich binucle-ar Pd(II) PC cherry-purple form (7).…”

Section: Biology Activity Of Pc Complexes Of D-elementsmentioning

confidence: 69%

ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

Demidov

Sukharzhevsky

Pakhomova

et al. 2022

Preprint

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Temperature accessible lowest electronic triplet biradical states of new metal 1,10-phenanthrocyani-nes were investigated by ESR spectroscopy. These are coordination compounds of a new structural class of cyanines: nanosize chromophore binuclear cation complexes of d-elements [Mz+Ln(µ-PC)]2Xn (Mz+=Zn2+, Cd2+, Pd2+and Pt2+; L=1,10-phen, py, AcO-; X=AcO-, Cl-) with electron-rich 1,10-phenanthrocyanine ligands. They are presented as redox-sensitive polymorphic soft collo-idal glasses capable of acting as inhibitors of tumor cell proliferation, environmentally friendly fun-gicides and DNA complexones related with NADH. The study of them by ESR spectroscopy sho-wed that one of the possible detailed mechanisms of the formation of triplet states in the processes of thermo-directed singlet-triplet S0→Tlow.-transitions consists in thermally activation of rotation around the sesquialteral C—C bond dihydro-1,10-phenanthroline and 1,10-phenanthroline frag-ments in the bridged chromophore system of compounds.

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Section: Biology Activity Of Pc Complexes Of D-elementsmentioning

confidence: 69%

ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

Demidov

Sukharzhevsky

Pakhomova

et al. 2022

Preprint

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“…The interaction of mononuclear 1,10-phenanthroline Cd(II) compounds with DNA has recently been studied [18]. Previously, we studied the complexation of DNA in an aqueous medium with the acetate 1,10-phenanthroline compound of Zn(II) Zn(phen) 2 (OAc) 2 [19]. DNA intercalation by the action of the complex [Zn(phen) 3 ] 2+ was discovered in [20].…”

Section: Introductionmentioning

confidence: 99%

Effect of the coordination centers and the solvents on the parameters of the 1H and 13C NMR spectra of biology active Zn+2 and Cd2+ acetate mononuclear complexes with chelating 1,10- phenanthroline

Demidov,

Ivanova,

Tsvetkova

et al. 2024

Preprint

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The NMR 1Н and 13С spectra of Zn+ 2 and Cd2+ acetate mononuclear complexes with 1,10-phenanthroline M(phen)n(OAc)2•2H2O (M = Zn2+ and Cd2+, n = 1–3) for their solutions in DMSO-d6, D2O and mixture DMSO-D6–D2O were studied. The effect of the coordination centers and the solvents on the parameters of the 1H and 13C NMR spectra is considered. It is noted that the chemical shifts of the δH protons of the heteroaromatic rings of 1,10-phenanthroline are sensitive to coordination with Zn+ 2 and Cd2+ ions, but the type of solvent has the greatest effect on the δН. For M(phen)n(OAc)2•2H2O (n = 1,2) complexes, the maximum shift to a weak field of δH values occurs for the mixed solvent DMSO-D6–D2O. For complexes [M(phen)3](OAc)2•2H2O in the mixed solvent DMSO-D6–D2O, on the contrary, there is a very weak shift of the values of δH in a strong field compared with the values for DMSO-D6 and in a weak field compared with the values in D2O. The difference in the 1H NMR spectral pattern for compounds M(phen)n(OAc)2•2H2O (n = 1,2) and [M(phen)3](OAc)2•2H2O should be associated with the coordination saturation of the latter, for which the insertion of a solvent – D2O or DMSO-D6 into the internal coordination sphere is practically impossible While the complexes M(phen)n(OAc)2•2H2O (n = 1,2) are coordination-unsaturated structures and allow solvent molecules to penetrate into their internal coordination sphere. Complexes of Zn+ 2 and Cd2+ with 1,10-phenanthroline were synthesized by complexation reactions.

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Investigation by ESR Spectroscopy of Biology Active Electron-Rich 1,10-Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

et al. 2023

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The Interaction of DNA with Phenanthroline and New Phenanthrocyanine Complexes of Zn(II)

Cited by 3 publications

References 31 publications

ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

ESR Spectroscopy of Temperature Accessible Lowest Triplet States of Biology Active Electron-Rich 1,10- Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

Effect of the coordination centers and the solvents on the parameters of the 1H and 13C NMR spectra of biology active Zn+2 and Cd2+ acetate mononuclear complexes with chelating 1,10- phenanthroline

Investigation by ESR Spectroscopy of Biology Active Electron-Rich 1,10-Phenanthrocyanines of d-Elements (Soft Colloidal Glasses)

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