“…Growth hormone has been variously stated to be without effect, to increase, to depress, and to have a biphasic action on glucose uptake of excised rat hemidiaphragm (1)(2)(3)(4)(5), on isolated perfused rat heart (6,7), and on the blood glucose concentration of man and rat (8,9). With respect to effects on fat metabolism, injection of growth hormone consistently provokes, within a matter of hours, a rise in plasma free fatty acids (FFA) (10,11), but in those experiments where earlier effects have been looked for, an initial hypolipacidemia has been reported (12,13).…”