The interaction of <i>AGT</i> and <i>NOS3</i> gene polymorphisms with conventional risk factors increases predisposition to hypertension

Gatti, R; Santos, Paula de Souza; Sena, Angela A.; Marangoni, Karina; Araújo, Messias Antônio; Goulart, Luiz Ricardo

doi:10.1177/1470320312452027

Cited by 10 publications

(10 citation statements)

References 44 publications

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“…The pathogenesis of hypertension involves major and minor genes and ambient influences, [22,23] in which the gene-gene and gene-environment interaction exist. [24][25][26] In this study, we did not observe the genetic variant, rs275653, in AGTR1 promoter region that was associated with hypertension. It suggested that AGTR1 rs275653 locus polymorphism may not be a valuable genetic marker for differential risk of essential hypertension among Chinese farmers.…”

Section: Discussioncontrasting

confidence: 65%

Association of AGTR1 gene methylation and its genetic variant in Chinese farmer with hypertension: A case-control study

et al. 2022

Medicine

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The objective was to determine the potential associations of the angiotensin II receptor type 1 (AGTR1) gene polymorphism, methylation, and lipid metabolism in Chinese farmers with hypertension. A case-control study was conducted in Wuzhi county of Henan province in China in 2013 to 2014. A total of 1034 local residents (35–74 years, 386 hypertensive cases, and 648 normotensive subjects) were enrolled in this study. Triglyceride (TG), total cholesterol (TC), high-density lipoprotein, and low-density lipoprotein were measured using automatic chemistry analyzer. The AGTR1 gene promoter methylation level was measured using quantitative methylation-specific polymerase chain reaction method. The single nucleotide polymorphism rs275653 was genotyped with TaqMan probe assay at an applied biosystems platform. The gender, body mass index (BMI), TG, TC, and family history of hypertension in the hypertension group were significantly higher than those in control group (P < .05). No significant difference was observed in the distribution of AGTR1 rs275653 polymorphism in the hypertension and controls (P > .05). The AGTR1 gene methylation in subjects carrying different genotypes was not significantly observed (P > .05). The logistic regression analysis found the AGTR1 gene methylation level was negative correlation with hypertension in the present study (odds ratio, 0.946, 95% confidence interval, 0.896–0.999) through adjusting for age, gender, BMI, education, smoking, alcohol drinking, fruit and vegetable intake, pickles intake, and family history of hypertension. The association of AGTR1 gene hypomethylation and essential hypertension was observed in Chinese farmers; no significant difference was observed in the distribution of AGTR1 rs275653 polymorphism.

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Section: Discussioncontrasting

confidence: 65%

Association of AGTR1 gene methylation and its genetic variant in Chinese farmer with hypertension: A case-control study

et al. 2022

Medicine

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“…Several genetic profiles have been identified as factors that influence the blood pressure homeostasis, such as endothelial nitric oxide synthase (eNOS), or polymorphisms encountered in the human angiotensinogen gene (AGT). 12,13…”

Section: Definitionsmentioning

confidence: 99%

An Updated Review of Hypertensive Emergencies and Urgencies

Makó

Ureche

Jeremiás

2018

Journal of Cardiovascular Emergencies

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A hypertensive crisis is an abrupt and severe rise in the arterial blood pressure (BP) occurring either in patients with known essential or secondary hypertension, or it may develop spontaneously. The most frequent cause for the severe and sudden increase in BP is inadequate dosing or stopping antihypertensive treatment in hypertensive patients. Severe hypertension can be defined as either a hypertensive emergency or an urgency, depending on the existence of organ damage. In hypertensive urgencies, there are no signs of acute end-organ damage, and orally administered drugs might be sufficient. In hypertensive emergencies, signs of acute end-organ damage are present, and in these cases, quickly-acting parenteral drugs must be used. The prompt recognition, assessment, and treatment of hypertensive urgencies and emergencies can decrease target organ damage and mortality. In this review, the definitions and therapeutic recommendations in a hypertensive crisis are presented in the light of the 2017 ACC/AHA Hypertension Guidelines.

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“…Diets high in NaCl increase the preponderance of hypertension in the population [42]. Genetic altercations in the renin-angiotensin system are linked to increased hypertension [43]. Age itself escalates blood pressure for the majority of individuals [44].…”

Section: Improving Animal Models: Role Of Comorbidities and Lifestylementioning

confidence: 99%

Neuroprotection for Ischemic Stroke: Moving Past Shortcomings and Identifying Promising Directions

Turner

Lucke‐Wold

Lucke-Wold

et al. 2013

IJMS

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The translation of neuroprotective agents for ischemic stroke from bench-to-bedside has largely failed to produce improved treatments since the development of tissue plasminogen activator (tPA). One possible reason for lack of translation is the failure to acknowledge the greatest risk factor for stroke, age, and other common comorbidities such as hypertension, obesity, and diabetes that are associated with stroke. In this review, we highlight both mechanisms of studying these factors and results of those that have been addressed. We also discuss the potential role of other lifestyle factors associated with an increased stroke risk such as sleep fragmentation and/or deprivation. Furthermore, many proposed therapeutic agents have targeted molecular mechanisms occurring soon after the onset of ischemia despite data indicating delayed patient presentation following ischemic stroke. Modulating inflammation has been identified as a promising therapeutic avenue consistent with preliminary success of ongoing clinical trials for anti-inflammatory compounds such as minocycline. We review the role of inflammation in stroke and in particular, the role of inflammatory cell recruitment and macrophage phenotype in the inflammatory process. Emerging evidence indicates an increasing role of neuro-immune crosstalk, which has led to increased interest in identification of peripheral biomarkers indicative of neural injury. It is our hope that identification and investigation of factors influencing stroke pathophysiology may lead to improved therapeutics.

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The interaction of AGT and NOS3 gene polymorphisms with conventional risk factors increases predisposition to hypertension

Cited by 10 publications

References 44 publications

Association of AGTR1 gene methylation and its genetic variant in Chinese farmer with hypertension: A case-control study

Association of AGTR1 gene methylation and its genetic variant in Chinese farmer with hypertension: A case-control study

An Updated Review of Hypertensive Emergencies and Urgencies

Neuroprotection for Ischemic Stroke: Moving Past Shortcomings and Identifying Promising Directions

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