The Interaction of Lanthanides with Amino Acids and Proteins

Evans, Christopher H.

doi:10.1007/978-1-4684-8748-0_4

Cited by 9 publications

(4 citation statements)

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“…They are also required for the proper functioning of vital cellular and organ networks [12,13]. It has been thoroughly examined how different lanthanides interact with a wide spectrum of proteins, amino acids, and polypeptides [14]. In complexation, lanthanides favour donor atoms in the following order: O>N>S and F>Cl.…”

Section: Introductionmentioning

confidence: 99%

“…[16] The inner structure of the lanthanide (III) complex can be revealed by examining the 4f-4f transition spectra. Using 4f-4f transition spectra recorded in various aquated organic solvents, the energy interaction and intensity parameters for the complexation of Pr (III) with amino acids, other ligands and polypeptides including O, N, and S donors were examined [13][14][15]. The spectroscopic characteristics of trivalent lanthanide ions are unusual.…”

Section: Introductionmentioning

confidence: 99%

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Absorption spectral study for the interaction of Pr(III) with L-Aspartic acid in various aquated organic solvents through 4f-4f transition spectra: Analysis of reaction pathways and thermodynamic parameters

2022

pnr

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The interaction of Praseodymium (III) with L-Aspartic Acid has been analysed theoretically through 4f-4f transition in various aquated organic solvents (DMF, ACN, Dioxane and methanol). Spectral parameters such as: Energy interaction parameters like Slater-Condon (Fk's), Lande factor (ξ4f), Racah energy (Ek), nephelauxetic effect (β), bonding (b1/2) and percent covalency (δ), as well as intensity parameters: oscillator strength 'P' and Judd-Ofelt Tλ (λ=2,4,6) were evaluated. The degree of outer and inner sphere coordination, the level of metal 4f-4f orbital involvement in the complexation, defining the immediate coordination environment around the metal Pr(III), and the coordination number of the complex formed could be revealed through the analysis of these spectral parameters. The rate of complexation for Pr(III) with L-Aspartic acid and consequently its thermodynamic parameters have been evaluated through 4f-4f transition spectra.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Absorption spectral study for the interaction of Pr(III) with L-Aspartic acid in various aquated organic solvents through 4f-4f transition spectra: Analysis of reaction pathways and thermodynamic parameters

2022

pnr

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“…[ 10 ] Lanthanum (La) is a naturally occurring rare earth element (atomic number: 57) that can be detected in the tissues of healthy individuals. [ 11 ] Lanthanum carbonate acts by dissociating in the acid environment of the upper gastrointestinal tract to release lanthanum ions that bind dietary phosphate released from food during digestion to form lanthanum phosphate, an insoluble compound that is poorly absorbed across the gut wall. [ 12 ] Lanthanum carbonate is well tolerated and the adverse effects were mainly gastrointestinal like nausea and vomiting.…”

Section: Introductionmentioning

confidence: 99%

Effect of lanthanum carbonate and calcium acetate in the treatment of hyperphosphatemia in patients of chronic kidney disease

2009

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Objectives:The tolerability and efficacy of lanthanum carbonate has not been studied in the Indian population. This study was, therefore, undertaken to compare the efficacy and tolerability of lanthanum carbonate with calcium acetate in patients with stage 4 chronic kidney disease.Design:A randomized open label two group cross-over study.Materials and Methods:Following Institutional Ethics Committee approval and valid consent, patients with stage 4 chronic kidney disease were randomized to receive either lanthanum carbonate 500mg thrice daily or calcium acetate 667 mg thrice daily for 4 weeks. After a 4-week washout period, the patients were crossed over for another 4 weeks. Serum phosphorous, serum calcium, serum alkaline phosphatase, and serum creatinine were estimated at fixed intervals.Results:Twenty-six patients were enrolled in the study. The mean serum phosphorous concentrations showed a declining trend with lanthanum carbonate (from pre-drug levels of 7.88 ± 1.52 mg/dL-7.14 ± 1.51 mg/dL) and calcium acetate (from pre-drug levels of 7.54 ± 1.39 mg/dL-6.51 ± 1.38 mg/dL). A statistically significant difference was seen when comparing the change in serum calcium produced by these drugs (P < 0.05). Serum calcium levels increased with calcium acetate (from pre-drug levels of 7.01 ± 1.07-7.46 ± 0.74 mg dL), while it decreased with lanthanum carbonate (from pre-drug levels 7.43 ± 0.77-7.14 ± 0.72 mg/dL). The incidence of adverse effects was greater with lanthanum carbonate.Conclusion:Lanthanum carbonate and calcium acetate are equally effective phosphate binders with trends obvious in the first 4 weeks of therapy. The decrease in serum calcium levels with lanthanum carbonate when compared to the increase in serum calcium levels due to calcium acetate is statistically significant. The drawback of lanthanum carbonate is its high cost and relatively higher incidence of adverse events during treatment.

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“…INTRODUCTION In lanthanides, rarely absorption spectra, involving 4f-4f transitions are used for mechanistic studies of the kinetic reactions involving lanthanide ions and coordinating ligands like biomolecules. The close resemblance between most abundant and biologically important Ca(II) ion and paramagnetic lanthanides(III) ions, in coordination and binding characteristics [1,2], allow lanthanide(III) ion to act as an "absorption spectral probe" in understanding biochemical reactions and functions involving isomorphous Ca(II) ion substitution by Ln(III) [3][4][5].…”

mentioning

confidence: 99%

A Probe into the Kinetics of the Interaction of Pr(III) Ions with Some Selected Amino Acids: A 4f-4f Transition Spectral Study

Moaienla¹,

Bendangsenla²,

Devi³

2014

AMSA

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The Interaction of Lanthanides with Amino Acids and Proteins

Cited by 9 publications

References 253 publications

Absorption spectral study for the interaction of Pr(III) with L-Aspartic acid in various aquated organic solvents through 4f-4f transition spectra: Analysis of reaction pathways and thermodynamic parameters

Absorption spectral study for the interaction of Pr(III) with L-Aspartic acid in various aquated organic solvents through 4f-4f transition spectra: Analysis of reaction pathways and thermodynamic parameters

Effect of lanthanum carbonate and calcium acetate in the treatment of hyperphosphatemia in patients of chronic kidney disease

A Probe into the Kinetics of the Interaction of Pr(III) Ions with Some Selected Amino Acids: A 4f-4f Transition Spectral Study

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