The interaction of metabolic factors with HCV infection: Does it matter?

Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication

“…3 Steatosis is present in almost 50% of patients infected by HCV, 4 and it has been reported to be associated with insuline resistance and hepatic fibrosis in some studies. [5][6][7] The mechanisms involved in HCV-induced steatosis seem to be mediated by HCV proteins, whose expression is associated with changes in host cell cholesterol/lipid metabolism. [8][9][10] Thereby, HCV core protein expression has been demonstrated to activate various pathways of lipid metabolism, contributing to the development of HCV-associated steatosis.…”

Dysregulation of distal cholesterol biosynthesis in association with relapse and advanced disease in CHC genotype 2 and 3 treated with sofosbuvir and ribavirin

“…In our study, patients with GT3 and cirrhosis had lower apoE and cholesterol at baseline compared to patients with GT2 with cirrhosis. Although some apoE isoforms have been associated with fibrosis in HCV GT1, we did not measure these isoforms in our cohort of HCV GT3 patients [6,8,10,11,13,14,[34][35][36][37].…”

“…Chronic hepatitis C (CHC) infection is associated with dyslipidemia and metabolic features that include insulin resistance, reduced serum total cholesterol, low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B levels [6][7]. These metabolic disturbances can lead to hepatic steatosis.…”

Successful Hepatitis C Antiviral Therapy Induces Remission of Type 2 Diabetes: A Case Report

“…However, insulin sensitivity appears to be impaired both in the liver and the periphery [20,21]. HCV impairs insulin signaling through direct and indirect mechanisms [22]. HCV directly impacts insulin signaling by interacting with specific proteins such as serine/threonine kinases that subsequently lead to inhibition or increased degradation of insulin signaling molecules [6,23].…”