The interaction of zinc with the multi-functional plasma thyroid hormone distributor protein, transthyretin: evolutionary and cross-species comparative aspects

Yamauchi, Kiyoshi

doi:10.1007/s10534-021-00294-0

Cited by 12 publications

(5 citation statements)

References 98 publications

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“…No information is yet available whether TH distribution in the blood [ 90 ] or TH transport across cellular membranes is affected by Se status. The multifunctional TH distributor protein transthyretin, originally evolved from the family of 5-hydroxyisourate hydrolases (HIUHase), contains zinc which is essential for T3 binding in fish but not for T4 and T3 binding in humans [ 91 ]. No transthyretin interactions with Se or I status have been reported.…”

Section: Selenoproteinsmentioning

confidence: 99%

Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism

Köhrle

2023

IJMS

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The adequate availability and metabolism of three essential trace elements, iodine, selenium and iron, provide the basic requirements for the function and action of the thyroid hormone system in humans, vertebrate animals and their evolutionary precursors. Selenocysteine-containing proteins convey both cellular protection along with H2O2-dependent biosynthesis and the deiodinase-mediated (in-)activation of thyroid hormones, which is critical for their receptor-mediated mechanism of cellular action. Disbalances between the thyroidal content of these elements challenge the negative feedback regulation of the hypothalamus–pituitary–thyroid periphery axis, causing or facilitating common diseases related to disturbed thyroid hormone status such as autoimmune thyroid disease and metabolic disorders. Iodide is accumulated by the sodium-iodide-symporter NIS, and oxidized and incorporated into thyroglobulin by the hemoprotein thyroperoxidase, which requires local H2O2 as cofactor. The latter is generated by the dual oxidase system organized as ‘thyroxisome’ at the surface of the apical membrane facing the colloidal lumen of the thyroid follicles. Various selenoproteins expressed in thyrocytes defend the follicular structure and function against life-long exposure to H2O2 and reactive oxygen species derived therefrom. The pituitary hormone thyrotropin (TSH) stimulates all processes required for thyroid hormone synthesis and secretion and regulates thyrocyte growth, differentiation and function. Worldwide deficiencies of nutritional iodine, selenium and iron supply and the resulting endemic diseases are preventable with educational, societal and political measures.

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Section: Selenoproteinsmentioning

confidence: 99%

Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism

Köhrle

2023

IJMS

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“…The major prion protein (PrP) (FC=1.7,p=0.008) may be involved in neuronal zinc homeostasis [27] . There is a correlation between transthyretin (FC=3.9,p=0.0004) and zinc [57] .…”

Section: Resultsmentioning

confidence: 99%

Changes of urinary proteome in rats after intragastric administration of zinc gluconate

Shen,

Yang,

Wang

et al. 2024

Preprint

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Zinc is an essential element for maintaining normal physiological function in living organisms. In this study, the urine proteome of rats before and after short-term intragastric administration of 82 mg/kg/d zinc gluconate (equivalent to 11.7 mg/kg/d zinc) was compared and analyzed. Many differential proteins have been reported to be zinc-related, such as mucin-2 (MUC-2) (14 times before compared with after gavage, p = 0.005) and transthyretin (3.9 times after gavage compared with before gavage, p = 0.0004). Biological processes enriched in differential proteins (e.g., regulation of apoptosis process, immune system process, etc.), molecular functions (e.g., calcium binding, copper binding, signaling receptor activity, etc.), KEGG pathways (e.g., complement and coagulation cascades, PI3K-Akt signaling pathway, etc.) showed correlation with zinc. In this study, we explore the overall effect of zinc on the body from the perspective of urine proteomics, which is helpful to deeply understand the biological function of zinc and broaden the application potential of urine proteomics.

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“…Iron, copper, and zinc have been shown to play an essential role in the stability and/or function of a variety of peptide hormones, and other metals with similar charge and ionic radius have also been demonstrated to bind to these hormones (Table 1). However, there are also examples of essential metals involved in direct metal binding to amino acid–derived hormones, hormone transport proteins that are important in the trafficking of steroid hormones, and hormone receptors (Hammond et al, 2003; Yamauchi, 2021; Table 1).…”

Section: Conceptual Model Of Metal Interactions With the Endocrine Sy...mentioning

confidence: 99%

Challenges and Recommendations in Assessing Potential Endocrine-Disrupting Properties of Metals in Aquatic Organisms

Brix,

Baken,

Poland

et al. 2023

Environmental Toxicology and Chemistry

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New tools and refined frameworks for identifying and regulating endocrine disrupting chemicals (EDCs) are being developed as our scientific understanding of how they work advances. Although focus has largely been on organic chemicals, the potential for metals to act as EDCs in aquatic systems is receiving increasing attention. Metal interactions with the endocrine system are complicated as some metals are essential to physiological systems, including the endocrine system, and non‐essential metals can have similar physio‐chemical attributes that allow substitution into or interference with these systems. Consequently, elevated metal exposure could potentially cause endocrine disruption, but can also cause indirect effects on the endocrine system via multiple pathways or elicit physiologically appropriate compensatory endocrine mediated responses (endocrine modulation). These latter two effects can be confused with, but are clearly not, endocrine disruption. In this paper, we provide several case studies that exemplify the challenges encountered in evaluating the endocrine disrupting (ED) potential of metals followed by recommendations on how to meet them. Given metals have multiple modes of action (MoAs), we recommend assessments use metal‐specific adverse outcome pathway networks to ensure accurate causal links are made between MoAs and effects on the endocrine system. We recommend more focus on establishing molecular initiating events for chronic metal toxicity as these are poorly understood and would reduce uncertainty regarding the potential for metals to be EDCs. Finally, more generalized MoAs such as oxidative stress could be involved in metal interactions with the endocrine system, and we suggest it may be experimentally efficient to evaluate these MoAs when ED is inferred. These experiments, however, must provide explicit linkage to the ED endpoints of interest.

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The interaction of zinc with the multi-functional plasma thyroid hormone distributor protein, transthyretin: evolutionary and cross-species comparative aspects

Cited by 12 publications

References 98 publications

Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism

Selenium, Iodine and Iron–Essential Trace Elements for Thyroid Hormone Synthesis and Metabolism

Changes of urinary proteome in rats after intragastric administration of zinc gluconate

Challenges and Recommendations in Assessing Potential Endocrine-Disrupting Properties of Metals in Aquatic Organisms

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