The interactions between gut and brain in gastrointestinal disorders

Surdea-Blaga, Teodora; Dumitraşcu, Dan L.; Pop, Andrei V.; Grad, Simona

doi:10.1016/b978-0-12-821927-0.00008-5

Cited by 2 publications

(2 citation statements)

References 157 publications

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“…Several mechanisms have been called into question, but the theories are still developing. Thus, dysfunctions on the hypothalamic–pituitary axis, neurotransmitters, vagus nerve, short-chain fatty acid metabolites, tryptophan, inflammatory factors and the brain–gut–microbiota axis have been investigated [ 9 , 10 , 11 , 12 ]. It has been proved that not only do stress-related disorders bring changes in the composition of the intestinal microbiota through the hypothalamic–pituitary–adrenal axis but also the intestine has an effect on the central nervous system through vagal stimulation, intestinal permeability and the release of inflammatory and anti-inflammatory compounds and changes in circulating agents in the blood [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease

Iordache

Tecchio

Aşchie

et al. 2022

JCM

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Depression is a global health problem that requires an early and accurate diagnosis to ensure quick access to appropriate treatment. Among multiple psychopathological paths, recent attention has focused on analysing the brain–gut–microbiota axis. The intestinal barrier plays a key role, and dysfunctions occurring at this level have implications for mental health. The aim of the present study was to investigate the role of intestinal permeability biomarkers, i.e., calprotectin, zonulin, lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FAB), in relation to depression in patients with inflammatory bowel disease (IBD). This is the first study of this kind taking place in Romania, Eastern Europe, with an emphasis on patients with Crohn’s disease and ulcerative colitis. The correlations identified between depression and calprotectin and depression and LBP have the potential to shed light on the process of rapid diagnosis of depression with the help of biomarkers. Since depression is correlated with a decrease in the quality of life in patients with IBD, the need for access to appropriate treatments must be urgent.

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Section: Introductionmentioning

confidence: 99%

Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease

Iordache

Tecchio

Aşchie

et al. 2022

JCM

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“…A more granular understanding of the mechanisms governing changes in brain function in relation to liver health will provide a foundation to further develop new diagnostic and therapeutic tools that can be used to improve the care of liver patients afflicted with these debilitating symptoms. The mechanism that links liver health to brain function is thought to be mediated through various avenues within the gut-liver-brain axis ( Ding et al, 2020 ; Blaga et al, 2021 ; Brescia and Rescigno, 2021 ; D’Mello and Swain, 2021 ). In this review, we will discuss the current understanding of the relationship between liver health and brain function through the lens of both clinical and basic science.…”

Section: Introductionmentioning

confidence: 99%

Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms

Nguyen

Swain

2023

Front. Neurosci.

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Symptoms of fatigue, social withdrawal and mood disturbances are commonly encountered in patients with chronic liver disease and have a detrimental effect on patient quality of life. Treatment options for these symptoms are limited and a current area of unmet medical need. In this review, we will evaluate the potential mechanistic avenues within the gut-liver-brain axis that may be altered in the setting of chronic liver disease that drive the development of these symptoms. Both clinical and pre-clinical studies will be highlighted as we discuss how perturbations in host immune response, microbiome, neural responses, and metabolites composition can affect the central nervous system.

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The interactions between gut and brain in gastrointestinal disorders

Cited by 2 publications

References 157 publications

Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease

Intestinal Permeability and Depression in Patients with Inflammatory Bowel Disease

Avenues within the gut-liver-brain axis linking chronic liver disease and symptoms

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