2024
DOI: 10.1021/acs.chemrestox.4c00378
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The Intercalator Ethidium Bromide Generates Covalent Adducts at Apurinic/Apyrimidinic Sites in DNA

Tanhaul Islam,
Saosan Binth Md Amin,
Kent S. Gates

Abstract: Ethidium bromide was first described as a DNA intercalator 60 years ago and, over the ensuing years, may be the most widely used fluorescent DNA stain in molecular biology, biochemistry, and histology. Noncovalent DNA binding by ethidium has been well characterized, but to date, there have been no reports of covalent DNA adduct formation by ethidium bromide. This report describes the characterization of covalent adducts generated by the reaction of ethidium with apurinic/ apyrimidinic (AP) sites in DNA. Adduct… Show more

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