<p><strong>Objective: </strong>To consider how manhood is a key social determinant of minority men’s health.</p><p><strong>Design: </strong>This commentary explicates how manhood intersects with other determinants of health to shape minority men’s stress responses, health behaviors and health outcomes across the life course.</p><p><strong>Results: </strong>Manhood, which perpetually needs to be proven, is an aspirational identity that is defined by the intersection of age, race/ethnicity and other identities. Minority men seek to and successfully embody US-cultural and ethnic-specific aspects of manhood in their daily lives by engaging in behaviors that constantly reaffirm their gender identity through a complex internal and social calculus that varies by intra-personal characteristics and context. Manhood and health are relational constructs that highlight how the salience of masculinities are shaped by perceived and actual social norms and expectations. A life course perspective adds a framework for considering how some gendered beliefs, goals and behaviors change over time while others remain static. Three life course frameworks highlight different mechanisms through which minority men’s life experiences and physiological and behavioral responses to gendered social norms, beliefs and expectations become embodied as premature mortality and other health outcomes over the life course.</p><p><strong>Conclusion: </strong>Manhood represents an important lens to understand how minority men’s identities, goals and priorities affect their health, yet the role of manhood in minority men’s health is understudied and underdeveloped. To achieve health equity, it is critical to consider how manhood shapes minority men’s lives and health across the life course, and to address how manhood affects gendered and non-gendered mechanisms and pathways that explain minority men’s health over time. <em>Ethn Dis. </em>2015;25(3):287-293.</p>