2020
DOI: 10.1111/eva.13031
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The interface between ecology, evolution, and cancer: More than ever a relevant research direction for both oncologists and ecologists

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Cited by 10 publications
(8 citation statements)
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“…Intratumor heterogeneity (ITH) is a constant in malignant neoplasms and the factor responsible for most therapeutic failures in clinical practice. Recent advances provided by massive genomic sequencing are showing the real scale and variability of spatial and temporal evolutionary patterns in many tumors [1][2][3]. Tumor evolution was initially considered to be a stochastic process, but some deterministic pathways correlating with prognosis have been identified recently [4].…”
Section: Significancementioning
confidence: 99%
“…Intratumor heterogeneity (ITH) is a constant in malignant neoplasms and the factor responsible for most therapeutic failures in clinical practice. Recent advances provided by massive genomic sequencing are showing the real scale and variability of spatial and temporal evolutionary patterns in many tumors [1][2][3]. Tumor evolution was initially considered to be a stochastic process, but some deterministic pathways correlating with prognosis have been identified recently [4].…”
Section: Significancementioning
confidence: 99%
“…This has led some authors to suggest that deciphering cancer’s secrets is more than a pure technological problem and that cancer should be also thought of as a sort of social dysfunction 3 . This approach opens up promising new prospects for envisaging the evolutionary dynamics of tumors under ecological principles 4 , 5 .…”
Section: Ecologymentioning
confidence: 99%
“…Recognition of the relative autonomy and evolvability of somatic cells opens a framework in which the concepts of habitat, diversity, niche, and population structure are key aspects of normal physiology [63,65]. So far considered mostly in the context of cancer [66][67][68], this eco-evolutionary perspective can be expanded also to capture the activity of cells in a healthy organism. Reconceptualizing certain forms of collective cell behavior as equivalent to that of a flock of birds or school of fish such a perspective could help to explain cell coordination in populational terms rather than in top-down regulation categories [64].…”
Section: Individuals As Collectivesmentioning
confidence: 99%