The interface of psychiatry and irritable bowel syndrome

Folks, David G.

doi:10.1007/s11920-004-0066-0

Cited by 84 publications

(71 citation statements)

References 63 publications

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“…31,32 Our study confirms the high prevalence of psychiatric symptoms, particularly anxiety, among IBS patients with concomitant Ni allergy. This study has few limitations.…”

Section: Discussionsupporting

confidence: 80%

Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet?

Rizzi

Nucera

Laterza

et al. 2017

J Neurogastroenterol Motil

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Background/AimsIrritable bowel syndrome (IBS) is characterized by chronic abdominal pain or discomfort accompanied by abnormal bowel movements. In sensitized subjects, ingested nickel (Ni) may induce gastrointestinal symptoms similar to IBS, in addition to typical systemic cutaneous lesions (systemic nickel allergy syndrome [SNAS]). A low nickel diet could improve the systemic manifestations. We evaluated prevalence of nickel allergy in IBS and effects of low Ni diet on (1) gastrointestinal symptoms control, (2) intestinal barrier function, (3) quality of life, and (4) psychological status of patients with IBS and Ni-sensitized patients. MethodsTwenty consecutive patients affected by IBS and suspected SNAS underwent intestinal permeability tests. Gastrointestinal symptoms were evaluated using the visual analogue scale before and after 3 months low Ni diet. Subjects with increased intestinal permeability at baseline repeated nuclear examination after the diet. ResultsThe most frequent profile was diarrhea-predominant IBS (8/20). The low Ni diet induced a significant and constant improvement of gastrointestinal symptoms and an equally significant improvement of visual analogue scale. Mean urinary output of 51 Chromium ethylene-diamine-tetra-acetate ( 51 Cr-EDTA) was 5.91%/24 hr (± 2.08), significantly different from the control group (2.20%/24 hr ± 0.60, P < 0.0001). ConclusionThis pilot study shows that low Ni diet improves gastrointestinal symptoms in patients with IBS and SNAS.

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“…31,32 Our study confirms the high prevalence of psychiatric symptoms, particularly anxiety, among IBS patients with concomitant Ni allergy. This study has few limitations.…”

Section: Discussionsupporting

confidence: 80%

Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet?

Rizzi

Nucera

Laterza

et al. 2017

J Neurogastroenterol Motil

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Section: Stress and Gut Motor Functionmentioning

confidence: 99%

“…Consequently, emphasis has been placed on elucidating the level of involvement of CRF signaling pathways, in both the brain and the gut, in the alterations of gut motor function known to be associated with stress (5,19). In addition, the clinical relevance of overactive CRF signaling in the brain and periphery in functional bowel diseases is receiving increasing interest (20,21), particularly because of the high prevalence of coexisting psychiatric disorders, prominently anxiety and depression, in IBS patients (22).In this Review, we first discuss recent advances in our knowledge of CRF signaling as it relates to CRF family members and their receptors, as well as the insight provided by the development of CRF receptor antagonists. Preclinical studies supporting a primary role for CRF receptor activation in the brain and gut in mediating the alterations of gastric and colonic motor function associated with exposure to various stressors are outlined.…”

mentioning

confidence: 99%

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Taché¹,

Bonaz²

2007

J. Clin. Invest.

317

285

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Over the past few decades, corticotropin-releasing factor (CRF) signaling pathways have been shown to be the main coordinators of the endocrine, behavioral, and immune responses to stress. Emerging evidence also links the activation of CRF receptors type 1 and type 2 with stress-related alterations of gut motor function. Here, we review the role of CRF receptors in both the brain and the gut as part of key mechanisms through which various stressors impact propulsive activity of the gastrointestinal system. We also examine how these mechanisms translate into the development of new approaches for irritable bowel syndrome, a multifactorial disorder for which stress has been implicated in the pathophysiology. Stress and gut motor functionA real or perceived threat to the homeostasis of mammalian organisms, originating internally or externally, triggers adaptive stress responses that affect behavior, as well as endocrine, immune, autonomic, and visceral functions (1, 2). Regarding effects in visceral functions in particular, early seminal investigations reported by Cannon and by Almy and colleagues provided clear evidence that emotional stress impacts gastric and colonic motor activity in healthy volunteers and cats (3, 4). Subsequent studies established that delayed emptying of the stomach is the most common response evoked by various acute stressors in both experimental animals and healthy human subjects (5). By contrast, in the colon, various stressors (including anxiety, dichotomous listening, fear, intermittent hand immersion in cold water, and stressful interviews) increase colonic motility in healthy subjects (5). Similarly, in rodents and dogs, stressors as diverse as open-field test, fear conditioning, loud sound, restraint, cold exposure, water avoidance, inescapable foot or tail shocks, and increased levels of cytokines induced by endotoxins stimulate propulsive colonic motor function (2, 5-7). The autonomic nervous system provides a peripheral neuronal network by which the effects of stress can be rapidly imposed on gut function. These are mediated through the sympathetic, and vagal and pelvic parasympathetic innervation of the enteric nervous system embedded into the muscular layers of the gut (8).It is becoming increasingly recognized that these interconnected brain-gut neuronal pathways activated during stress have relevance in the pathophysiology of functional bowel disorders (9-11). In particular, various stressors in the form of early life trauma, sexual abuse, maternal neglect, fear conditioning, lifethreatening events, and enteric infection have an important role in the etiology of irritable bowel syndrome (IBS), which is characterized by altered bowel movements, bloating, and visceral pain (10-13). Cyclic vomiting syndrome is another brain-gut disorder manifested by recurrent, stereotyped episodes of nausea and vomiting in the pediatric population, which is triggered by stressors related to heightened emotional state, fasting, exercise, and infection in 80% of the patients (14).A big step forward...

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“…According to the results of some researches, psychological stressors and traumatic factors have important role in generation symptoms of IBS [9].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Dialectical Behavior Therapy on Stress, Resilience and Coping Strategies in Irritable Bowel Syndrome Patients

Haghayegh

Doost

Adibi

et al. 2017

Zahedan J Res Med Sci

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The interface of psychiatry and irritable bowel syndrome

Cited by 84 publications

References 63 publications

Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet?

Irritable Bowel Syndrome and Nickel Allergy: What Is the Role of the Low Nickel Diet?

Corticotropin-releasing factor receptors and stress-related alterations of gut motor function

Efficacy of Dialectical Behavior Therapy on Stress, Resilience and Coping Strategies in Irritable Bowel Syndrome Patients

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