The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior

Ruan, Changshun; Hu, Nan; Ma, Yufei; Li, Yuxiao; Liu, Juan; Zhang, Xinzhou; Pan, Haobo

doi:10.1038/s41598-017-06354-1

Cited by 41 publications

(36 citation statements)

References 45 publications

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“…Additionally, pins obtained from decellularized human or bovine cortical bone have been described [19]. However, the application of these resorbable pins has been associated with different issues, such as a low biocompatibility (e.g., due to the degradation products) or a lack of mechanical functionality for maintaining a secure fixation [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Jung

Hesse²,

Stojanović

et al. 2021

IJMS

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Background: Magnesium (Mg) is one of the most promising materials for human use in surgery due to material characteristics such as its elastic modulus as well as its resorbable and regenerative properties. In this study, HF-coated and uncoated novel bioresorbable magnesium fixation screws for maxillofacial and dental surgical applications were investigated in vitro and in vivo to evaluate the biocompatibility of the HF coating. Methods: Mg alloy screws that had either undergone a surface treatment with hydrofluoric-acid (HF) or left untreated were investigated. In vitro investigation included XTT, BrdU and LDH in accordance with the DIN ISO 10993-5/-12. In vivo, the screws were implanted into the tibia of rabbits. After 3 and 6 weeks, degradation, local tissue reactions and bony integration were analyzed histopathologically and histomorphometrically. Additionally, SEM/EDX analysis and synchrotron phase-contrast microtomography (µCT) measurements were conducted. The in vitro analyses revealed that the Mg screws are cytocompatible, with improved results when the surface had been passivated with HF. In vivo, the HF-treated Mg screws implanted showed a reduction in gas formation, slower biodegradation and a better bony integration in comparison to the untreated Mg screws. Histopathologically, the HF-passivated screws induced a layer of macrophages as part of its biodegradation process, whereas the untreated screws caused a slight fibrous tissue reaction. SEM/EDX analysis showed that both screws formed a similar layer of calcium phosphates on their surfaces and were surrounded by bone. Furthermore, the µCT revealed the presence of a metallic core of the screws, a faster absorbing corrosion front and a slow absorbing region of corroded magnesium. Conclusions: Overall, the HF-passivated Mg fixation screws showed significantly better biocompatibility in vitro and in vivo compared to the untreated screws.

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Section: Introductionmentioning

confidence: 99%

Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Jung

Hesse²,

Stojanović

et al. 2021

IJMS

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“…The use of cross-linking agents with different functionality mixed with polyols that are the primary raw materials of the aqueous phase leads to the preparation of PU materials with hydrophilic surfaces that can enhance the osteogenic differentiation [ 20 ]. This modification of the hydrophilic character improves the aqueous solubilization of PU drug carriers and leads to a more intense therapeutic effect of active substances with low water solubility.…”

Section: Discussionmentioning

confidence: 99%

A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media

et al. 2020

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Polyurethane nano- and micro-structures have been studied intensively in the last decade as drug delivery systems for various herbal extracts as well as pure active biological substances. Their biocompatibility, haemocompatibility, safe degradation, and low-cost production are just a few advantages of these materials that were already used in numerous medical applications (catheters, surgical drapes, wound dressing). The primary purposes of this study include obtaining empty polyurethane microstructures and the assessment of their modifications in media with different pH values. A mixture of two aliphatic diisocyanates and an aqueous phase based on a polyether were used during the synthesis process. The size, homogeneity, and surface charge were studied using a Cordouan Technol. Zetasizer, while the pH measurements were conducted with a portable pH Meter Checker®, Hanna Instruments. The results showed the obtaining of an almost homogeneous sample containing microstructures with sizes ranging between 139 and 151 nm, with a pH value of approximately 6.78 and a Zeta potential of 24.6. Expected decreases in microparticles’ sizes were observed in all types of media during a 15-days experiment, but the process was accelerated by a low pH when an increase of the Zeta potential value was noticed as well. Our data provide new information about the degradation process of the polyurethane microstructures on the one hand and the drug release rate of these materials when used as drug carriers, on the other hand.

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“…8 . These higher properties were explained by a stable neutral pH over time via PDLLA acidic degradation products neutralization by piperazine [ 240 , 241 ]. They also demonstrated that cell behavior regulation can potentially be achieved by SMP stretching-induced nanostructure [ 242 ].…”

Section: Biobased Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

244

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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The interfacial pH of acidic degradable polymeric biomaterials and its effects on osteoblast behavior

Cited by 41 publications

References 45 publications

Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

Biocompatibility Analyses of HF-Passivated Magnesium Screws for Guided Bone Regeneration (GBR)

A Study on the Behavior of a Polyurethane Drug Carrier in Various pH Media

Biobased polyurethanes for biomedical applications

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