The interferon‐gamma (IFN‐γ) +874T allele reduces the risk of hepatitis B infection in an Asian population

Abstract

Increasing evidence suggests that polymorphism of the interferon-gamma (IFN-γ) gene in the first intron at position +874 may be associated with chronic hepatitis B virus (HBV) infection and/or HBV clearance. However, the results of relevant studies have been inconsistent. To derive a more precise estimation of the association, we performed a meta-analysis. In total, 10 independent studies including 1661 chronic HBV-infected patients and 1142 controls were included in this meta-analysis. In studies following Hardy-Weinberg equilibrium (HWE), a significantly decreased risk of chronic HBV infection was associated with the IFN-γ + 874TT genotype in the overall population (TT vs AA: odds ratio (OR) = 0.714, 95% confidence interval (CI) = 0.526-0.969, P = 0.031) when compared with a spontaneously recovered population. Subgroup analysis by ethnicity revealed a similar association in Asian individuals (TT vs AA: OR = 0.706, 95% CI = 0.518-0.962, P = 0.028). Moreover, when compared with a healthy control group, the 874T allele was associated with a significant lower risk of chronic HBV infection in the overall populations (TA vs AA: OR = 0.439, 95% CI = 0.193-0.997, P = 0.049; TT + TA vs AA: OR = 0.475, 95% CI = 0.271-0.832, P = 0.009) and in Asian individuals (TA vs AA: OR = 0.862, 95% CI = 0.744-0.999, P = 0.048). In conclusion, the IFN-γ + 874TT genotype and 874T allele reduce the risk of chronic HBV infection in Asian individuals.

Interferon Gamma +874T/A Polymorphism Increases the Risk of Hepatitis Virus-Related Diseases: Evidence from a Meta-Analysis

“…We noticed that the meta-analysis by Ge et al[ 46 ] also suggested that the +874T/A polymorphism may not contribute to HCC susceptibility with three studies, which was verified by our meta-analysis with six studies. In addition, Sun et al [ 47 ] also performed a meta-analysis of the +874T/A polymorphism and CHB risk with five studies, and their results indicated the TT genotype and the T allele reduce the risk of chronic HBV infection in Asian individuals, which was similar to our meta-analysis of nine studies. However, we did not observed a significant association in co-dominant models.…”

Association between the interferon-γ +874T/A polymorphism and susceptibility to hepatitis B virus infection: a meta-analysis

“…Our findings are consistent with the meta-analysis conducted by Sun et al. 32 in Asian populations which showed that the IFN-γ +874T/A T allele was a protective factor against chronic hepatitis B infection, with significant differences seen in dominant, homozygous, and heterozygous genetic models.…”

“…Excluding the control group that did not meet HWE, the repeat metaanalysis showed that the heterogeneity of each genetic model increased, so HWE was not the main source of heterogeneity. Our findings are consistent with the metaanalysis conducted by Sun et al 32 in Asian populations which showed that the IFN-c þ874T/A T allele was a protective factor against chronic hepatitis B infection, with significant differences seen in dominant, homozygous, and heterozygous genetic models.…”

IL-18,TNF, andIFN-γalleles and genotypes are associated with susceptibility to chronic hepatitis B infection and severity of liver injury

“…In addition to TNF , the IL‐18 −607 A/A and IL‐18 −137 G/G genotypes were associated with susceptibility for chronic HBV infection in Thai [Hirankarn et al, ] and Chinese [Zhang et al, ; Li et al, ] patients, respectively; and the IFN γ +874 A allele and the −2109 G/+874 A haplotype were associated with susceptibility for chronic HBV infection in a Chinese population [Liu et al, ]. Conversely the IFN γ +874 T allele and +874 TT genotype were associated with lower risk for chronic HBV infection in Chinese patients [Sun et al, ].…”