The interlink between climate changes, gut microbiota, and aging processes

Gunawan, William Ben; Abadi, Muhammad Naufal Putra; Fadhillah, Farhan Syafiq; Nurkolis, Fahrul; Pramono, Adriyan

doi:10.1016/j.hnm.2023.200193

Cited by 8 publications

(5 citation statements)

References 95 publications

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“…High temperature Declines in soil biodiversity [9] Higher ratio Bacteroidetesto-Firmicutes [103] Increase in proportion of potentially pathogenic [107] bacteria (Escherichia, Shigella, and Lactococcus) Increase of IL-10, IL-6, CXCL2, CCL4, CCL5, and CCL11 [107] Increase of ALT, ALP, creatinine, LDH, α-HBDH, and cholinesterase [107] Decrease in probiotics (Dorea, Blautia, and Lactobacillus) [107] Cold temperature…”

Section: Temperature Alteration Of Gm Referencesmentioning

confidence: 99%

“…Climate change is forecasted to alter the composition of soil microbes, as temperature is one of the factors influencing the growth rate of organisms. With a decrease in the number of microbes in the soil, there could be a potential depletion of the GM in humans due to a reduction in soil biodiversity [ 9 ]. The low organic content of the soil will also affect the quality of crops and agricultural productivity.…”

Section: Climate Change and The Gut Microbiomementioning

confidence: 99%

“…Several studies suggest the role of climate change in modifying the soil microbiome, which is inextricably linked to the quality of food crops [ 9 ]. Modern research has been delineating the influence of the soil microbiome on various physiological processes, such as digestion, vitamin and mineral production, mental health, and immune function [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Rio,

Caldarelli,

Gasbarrini

et al. 2024

Diseases

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According to the definition provided by the United Nations, “climate change” describes the persistent alterations in temperatures and weather trends. These alterations may arise naturally, such as fluctuations in the solar cycle. Nonetheless, since the 19th century, human activities have emerged as the primary agent for climate change, primarily attributed to the combustion of fossil fuels such as coal, oil, and gas. Climate change can potentially influence the well-being, agricultural production, housing, safety, and employment opportunities for all individuals. The immune system is an important interface through which global climate change affects human health. Extreme heat, weather events and environmental pollutants could impair both innate and adaptive immune responses, promoting inflammation and genomic instability, and increasing the risk of autoimmune and chronic inflammatory diseases. Moreover, climate change has an impact on both soil and gut microbiome composition, which can further explain changes in human health outcomes. This narrative review aims to explore the influence of climate change on human health and disease, focusing specifically on its effects on the immune system and gut microbiota. Understanding how these factors contribute to the development of physical and mental illness may allow for the design of strategies aimed at reducing the negative impact of climate and pollution on human health.

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Section: Temperature Alteration Of Gm Referencesmentioning

confidence: 99%

Section: Climate Change and The Gut Microbiomementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

Rio,

Caldarelli,

Gasbarrini

et al. 2024

Diseases

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“…The gut microbiome also plays a role in nutrient metabolism and absorption. Changes in the gut microbiome with age can affect the breakdown and utilization of dietary nutrients, influencing energy balance, metabolism, and overall nutrient status, all of which are important factors in the aging process [11]. Additionally, the gut microbiome influences the integrity and function of the intestinal barrier.…”

Section: Introductionmentioning

confidence: 99%

The Trajectory of Successful Aging: Insights from Metagenome and Cytokine Profiling

Chulenbayeva,

Ganzhula,

Kozhakhmetov

et al. 2024

Gerontology

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Introduction: The longevity is influenced by of genetic, environmental, and lifestyle factors. The specific changes that occur in the gut microbiome during the aging process, and their relationship to longevity and immune function, have not yet been fully understood. The ongoing research other microbiome based to longevity cohort in Kazakhstan, provides preliminary information on longevity-related aging, where cytokine expression is associated with specific microbial communities and microbial functions. Methods: Metagenomic shotgun sequencing study of 40 long-lived individuals aged 90 years and over were carried out, who were conditionally healthy and active, able to served themselves, without a history of serious infection and cancer, who had not taken any antimicrobials, including probiotics. Blood serum weas analyzed to clinical and laboratory characteristics. The cytokine and chemokine profile in serum and stool samples was assessed using Multiplex analysis. Results: We found a significant increase in the expression of pro-inflammatory cytokines IL-1a, IL-6, 12p70, IP-10, IFN-α2, IL-15 TNFa, as well as chemokines MIP-1a/CCL3 and MIP-1b/CCL4, chemokine motif ligands MCP-3/CCL7 and MDC/CCL22(1c). Nonagenerians and centenarians demonstrated a greater diversity of core microbiota genera and showed an elevated prevalence of the genera Bacteroides, Clostridium, Escherichia and Alistipes. Conversely, there was a decrease in the abundance of the genera Ruminococcaceae, Fusicatenibacter, Dorea, as well as the species Fusicatenibacter saccharivorans. Furthermore, functional analysis revealed that the microbiome in long-lived group has a high capacity for lipid metabolism, amino acid degradation, and potential signs of chronic inflammatory status. Conclusion: Long-lived individuals exhibit an immune system imbalance and observed changes in the composition of the gut microbiota at the genus level between to the two age groups. Age-related changes in the gut microbiome, metabolic functions of the microbial community, and chronic inflammation all contribute to immunosenescence. In turn, the inflammatory state and microbial composition of the gut is related to nutritional status.

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“…Fundamentally, the process of skin aging comprises the cumulative effects of both intrinsic biological aging and extrinsic aging instigated by external environmental elements, including pollution, exposure to cigarette smoke, ultraviolet (UV) radiation, and inflammatory stimuli [1], in addition to the possibility of aging owing to climate change [2]. The aging process is characterized by the formation of reactive oxygen species (ROS) via signal transduction, activation of mTOR/AP-1 signaling proteins, and downregulation of SIRT-1/AMPK signaling [3].…”

Section: Introductionmentioning

confidence: 99%

Coffee Silverskin Phytocompounds as a Novel Anti-Aging Functional Food: A Pharmacoinformatic Approach Combined with In Vitro Study

Hayes,

Nurkolis,

Laksemi

et al. 2023

Molecules

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Coffee became a beverage that was in demand in the world and consequently produced millions of tons of coffee byproducts namely coffee silverskin (CS). Unutilized CS will be waste and cause environmental pollution such as greenhouse gas emissions, landfill waste, and groundwater contamination. This is a research concern at this time, although many studies have been conducted to find newer applications of CS, exploration of its benefits in the health sector is still limited. Therefore, exploring the benefits of CS to prevent or delay aging will be very interesting to develop in functional food industry technology. Therefore, this study aims to report profiling metabolites or phytochemicals, biological activities in terms of antioxidant activity, and potential anti-aging of CS via molecular docking simulation and in vitro modulation of the mTOR/AMPK/SIRT1 pathway. Something new has been obtained from this work, the profile of phytocompounds, and biological activities both in molecular docking simulation and in vitro studies. Some of the compounds observed in Robusta CS extract (rCSE) such as Epicatechin, Kaempferol, and Quercitrin, and Arabica CS extract (aCSE) such as (+)-Catechin dan Naringin have promising potential as inhibitors of iNOS, mTOR, and HIF-1α via molecular docking simulation. Interestingly, the in vitro biological activity assay of antioxidant and anti-aging activity, rCSE showed the same promising potential as the results of a molecular docking simulation. More interestingly, AMPK/SIRT1/mTOR expressions are well modulated by rCSE compared to aCSE significantly (p < 0.05). This makes the rCSE have promising biological activity as a candidate for functional food development and/or treatment agent in combating free radicals that cause the aging process. In vivo studies and human trials are certainly needed to see the further efficacy of the rCSE in the future.

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The interlink between climate changes, gut microbiota, and aging processes

Cited by 8 publications

References 95 publications

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

The Impact of Climate Change on Immunity and Gut Microbiota in the Development of Disease

The Trajectory of Successful Aging: Insights from Metagenome and Cytokine Profiling

Coffee Silverskin Phytocompounds as a Novel Anti-Aging Functional Food: A Pharmacoinformatic Approach Combined with In Vitro Study

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