The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)—quality of life during the first 4 months after fracture

Borgström, Fredrik; Lekander, Ingrid; Ivergård, M; Ström, O.; Svedbom, Axel; Alekna, Vidmantas; Bianchi, Maria Luisa; Clark, Patricia; Curiel, Manuel Dı́az; Dimai, Hans Peter; Jürisson, Mikk; Kallikorm, Riina; Lesnyak, Olga; McCloskey, Eugène; Nassonov, E.; Sanders, Kerrie M.; Silverman, Stuart L.; Tamulaitienė, Marija; Thomas, Thierry; Tosteson, Anna N.A.; Jönsson, Bengt; Kanis, John А.

doi:10.1007/s00198-012-2240-2

Cited by 129 publications

(101 citation statements)

References 34 publications

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“…The results presented here support previous research demonstrating that hip fractures are associated with a substantial decrement in HrQoL [11,[22][23][24]. In a systematic review, hip fractures were associated with a HrQoL decrement of approximately 50 % shortly after fracture and 20 % 4 months after fracture [23].…”

Section: Discussionsupporting

confidence: 89%

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The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

2015

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Summary The study rationale was to provide a detailed overview of the costs, quality of life and mortality of hip fractures in Portugal. Mean individual fracture-related costs were estimated at €13, 434 [12,290; 14,576] for the first year and €5985 [4982; 7045] for the second year following the fracture. Introduction Osteoporotic fractures represent a remarkable burden to health care systems and societies worldwide, which will tend to increase as life expectancy expands and lifestyle changes favour osteoporosis. The cost-effectiveness evaluation of intervention strategies demands accurate data on the epidemiological and economical reality to be addressed. Methods Information was collected retrospectively on consumption of resources and changes in quality of life attributable to fracture as well as mortality, regarding 186 patients randomly selected to represent the distribution of hip fractures in the Portuguese population, in terms of gender, age and geographical provenience. Data were cross-tabulated with socio-demographic variables and individual resource consumption to estimate the burden of disease. A societal perspective was adopted, including direct and indirect costs.Multivariate analyses were carried out to assess the main determinants of health-related quality of life (HrQoL). Results Mean individual fracture-related costs were estimated at €13, 434 [12,290; 14,576] for the first year and €5985 [4982; 7045] for the second year following the fracture. In 2011 the economic burden attributable to osteoporotic hip fractures in Portugal could be estimated at €216 million. Mean reduction in HrQoL 12 months after fracture was estimated at 0.34. Regression analysis showed that age was associated with a higher loss of HrQoL, whereas education had the opposing effect. We observed 12 % excess mortality in the first year after hip fracture, when compared to the gender and age-matched general population. Conclusions Results of this study indicate that osteoporotic hip fractures are, also in Portugal, despite its low incidence of fractures and cost per event, associated with a high societal burden, in terms of costs, loss in HrQoL and mortality. These data provide valuable input to the design and selection of fracture prevention strategies.

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Section: Discussionsupporting

confidence: 89%

“…This difference may be related to the exact time of evaluation, as HrQoL changes rapidly under these circumstances. Cultural issues may also play a role [22].…”

Section: Discussionmentioning

confidence: 99%

The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

2015

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“…16. [95,96] The clinical and cost-effectiveness of fracture liaison services has been demonstrated in several centres [97][98][99][100][101]. In an analysis of data collected over 8 years in Glasgow it was estimated that the service prevented 18 hip fractures and saved £21,000 per 1000 patients [102].…”

Section: Fracture Liaison Servicesmentioning

confidence: 99%

“…Consequently, fractures result in reduced health utility and reductions differ substantially among the fracture types, and likely between countries [99]. Hip and vertebral fractures have the greatest impact on health utility whereas forearm fractures are associated with less health utility loss over a shorter period of time; most patients return to their pre-fracture utility after 12 months [99]. The loss of health utility is greatest for all fractures in the first year and decreases in subsequent years [98].…”

Section: Health Utility and Qaly Implications Of Fracturementioning

confidence: 99%

Osteoporosis in the European Union: medical management, epidemiology and economic burden

Hernlund¹,

Svedbom²,

Ivergård³

et al. 2013

Arch Osteoporos

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2,133

1,048

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Summary This report describes the epidemiology, burden, and treatment of osteoporosis in the 27 countries of the European Union (EU27). Introduction Osteoporosis is characterized by reduced bone mass and disruption of bone architecture, resulting in increased risk of fragility fractures which represent the main clinical consequence of the disease. Fragility fractures are associated with substantial pain and suffering, disability and even death for affected patients and substantial costs to society. The aim of this report was to characterize the burden of osteoporosis in the EU27 in 2010 and beyond. Methods The literature on fracture incidence and costs of fractures in the EU27 was reviewed and incorporated into a model estimating the clinical and economic burden of osteoporotic fractures in 2010.Results Twenty-two million women and 5.5 million men were estimated to have osteoporosis; and 3.5 million new fragility fractures were sustained, comprising 610,000 hip fractures, 520,000 vertebral fractures, 560,000 forearm fractures and 1,800,000 other fractures (i.e. fractures of the pelvis, rib, humerus, tibia, fibula, clavicle, scapula, sternum and other femoral fractures). The economic burden of incident and prior fragility fractures was estimated at € 37 billion. Incident fractures represented 66 % of this cost, long-term fracture care 29 % and pharmacological prevention 5 %. Previous and incident fractures also accounted for 1,180,000 quality-adjusted life years lost during 2010. The costs are expected to increase by 25 % in 2025. The majority of individuals who have sustained an osteoporosis-related fracture or who are at high risk of fracture are untreated and the number of patients on treatment is declining.

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“…There is currently a substantial body of literature supporting the use of percutaneous balloon kyphoplasty for the treatment of symptomatic compression fractures [5][6][7][8][9][10][11]. The procedure is minimally invasive, and it can frequently be performed in an outpatient setting.…”

Section: Introductionmentioning

confidence: 99%

Safety and Efficacy of Balloon Kyphoplasty for Compression Fractures in the Very Elderly

Gandhoke¹,

Deibert²,

Paschel³

et al. 2014

Cureus

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The International Costs and Utilities Related to Osteoporotic Fractures Study (ICUROS)—quality of life during the first 4 months after fracture

Abstract: The findings in this study indicate that there appear to be important variations in the QoL decrements related to fracture between countries.

Cited by 129 publications

References 34 publications

The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

The burden of osteoporotic hip fractures in Portugal: costs, health related quality of life and mortality

Osteoporosis in the European Union: medical management, epidemiology and economic burden

Safety and Efficacy of Balloon Kyphoplasty for Compression Fractures in the Very Elderly

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